Results 71 to 80 of about 6,453 (193)
Natural History of Alternaria Sensitisation and Association With Asthma and Rhinitis From Childhood to Adulthood
Allergy, EarlyView.We aimed to characterise Alternaria sensitisation trajectories from childhood to adulthood; we compared SPT, whole‐extract sIgE and rAlt a 1, and assessed their longitudinal association with asthma and rhinitis in the Isle of Wight birth cohort. Alternaria sensitisation in the Isle of Wight Birth Cohort emerges mainly in late adolescence and, when ...Mohammad Leily, Hongmei Zhang, Graham Roberts, Pandurangan Vijayanand, Magnus Bores, Eva Södergren, Ramesh J. Kurukulaaratchy, S. Hasan Arshad +7 morewiley +1 more sourceSerotonin Degradation and Lipid Metabolism Regulate Human Tc2 Cell Effector Functions
Allergy, EarlyView.Human Tc2 cells exhibit a metabolically active phenotype characterized by enhanced glycolysis, mitochondrial respiration, and fatty acid uptake dependent on PPARγ. Alarmins strongly amplify IL‐5 and IL‐13 production in Tc2 cells, supporting a shared immunometabolic program across type 2 lymphocytes.Sabrina de Souza Ferreira, Lisa Holla, Sophia Björkander, Marie Kaarup Bek, Lorenz Wirth, Patrick A. Shearer, Jesper Säfholm, Erik Sachs, Mamdoh Al‐Ameri, Kasra Vali, Sandra Ekström, Erik Melén, Jenny Mjösberg, Christopher Andrew Tibbitt +13 morewiley +1 more sourceRemission in Global Airway Diseases: EUFOREA Consensus Paper
Allergy, EarlyView.ABSTRACT
The therapeutic goal in chronic airway diseases is shifting from symptom control to disease remission. Disease‐modifying therapies, including biologics and allergen immunotherapy, have made remission achievable in patients with severe asthma, chronic rhinosinusitis with nasal polyps (CRSwNP), or allergic rhinitis (AR).J. Christian Virchow, Xander Bertels, Vibeke Backer, Benjamin S. Bleier, Marco Caminati, Diego M. Conti, Eugenio De Corso, Mina Gaga, Valerie J. Lund, Corrado Pelaia, Anju T. Peters, Glenis K. Scadding, Martin Wagenmann, Riyad O. Al‐Lehebi, Guy G. Brusselle, Philippe Gevaert, Liam G. Heaney, Stella E. Lee, Florence Schleich, Frederik Trinkmann, Peter W. Hellings, Wytske J. Fokkens, Paola Rogliani +22 morewiley +1 more sourceClinical Features of Cellular Senescence Pathways in Severe Asthma
Allergy, EarlyView.In bronchial biopsies, SASP and p53 pathway enrichment scores are elevated in severe asthma versus non‐severe asthma and healthy controls. SASP enrichment is validated in the independent NOVA cohort. SASP enrichment is also elevated in nasal brushings of participants with nasal polyps, independently of asthma status.Woo‐Jung Song, Nazanin Zounemat Kermani, Ali Versi, Stephany Sánchez‐Ovando, Jodie Louise Simpson, Peter A. Wark, Katherine Joanne Baines, Sven‐Erik Dahlén, Ratko Djukanovic, Yike Guo, Ian M. Adcock, Kian Fan Chung, on behalf of the U‐BIOPRED Study Group, Mahmoud. I. Abdel‐Aziz, Ian M. Adcock, Lars I. Andersson, Charles Auffray, Yusef E. Badi, Per Bakke, Aruna T. Bansal, Frederic Baribaud, Stewart A. Bates, Elisabeth H. Bel, Jeanette Bigler, Bo Billing, Hans Bisgaard, Michael J. Boedigheimer, Klaus Bønnelykke, Joost Brandsma, Paul Brinkman, Enrica Bucchioni, Dominic Burg, Andrew Bush, Massimo Caruso, Romanas Chaleckis, Pascal Chanez, Kian Fan Chung, T. Checa, Chris H. Compton, Julie Corfield, Danen Cunoosamy, Arnaldo D'Amico, Barbro Dahlén, Sven‐Erik Dahlén, Bertrand De Meulder, Ratko Djukanovic, Veit J. Erpenbeck, Damijan Erzen, K. Fichtner, Louise J. Fleming, Elena Formaggio, Stephen J. Fowler, Urs Frey, Martina Gahlemann, Thomas Geiser, Victoria Goss, Yike Guo, Simone Hashimoto, John Haughney, Gunilla Hedlin, Pieter‐Paul W. Hekking, Timothy Higenbottam, Jens M. Hohlfeld, Cecile Holweg, Ildiko Horvath, Peter Howarth, Anna J. James, Richard G. Knowles, Johan Kolmert, Jon Konradsen, Norbert Krug, Nikos Lazarinis, C.‐X. Li, Matthew J. Loza, Rene Lutter, Alexander Manta, Sarah Masefield, Anke H. Maitland‐van der Zee, John G. Matthews, Alexander Mazein, Roelinde J. M. Middelveld, Montserrat Miralpeix, Paolo Montuschi, Jacek Musial, Sharon Mumby, David Myles, Björn Nordlund, Ioannis Pandis, Stelios Pavlidis, Anthony Postle, P. Powel, G. Praticò, M. Puig Valls, N. Rao, Stacey Reinke, John Riley, Amanda Roberts, Graham Roberts, Anthony Rowe, Thomas Sandström, Jim P. R. Schofield, Wolfgang Seibold, Dominic E. Shaw, R. Sigmund, Florian Singer, Paul J. Skipp, M. Smicker, Ana R. Sousa, Maria Sparreman‐Mikus, Peter J. Sterk, Marika Ström, Kai Sun, Bob Thornton, Mohib Uddin, Ali Versi, Jorgen Vestbo, Nadja H. Vissing, Scott S. Wagers, Åsa Wheelock, Craig E. Wheelock, Susan J. Wilson, Valentyna Yasinska, Nazanin Zounemat Kermani +122 morewiley +1 more sourceAnnual Fractional Exhaled Nitric Oxide Measurements and Exacerbations in Severe Asthma
Journal of Asthma and Allergy, 2020 Yuki Abe, Masaru Suzuki, Hirokazu Kimura, Kaoruko Shimizu, Hironi Makita, Masaharu Nishimura, Satoshi Konno Department of Respiratory Medicine, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Kita-ku, Sapporo 060-8638 ...Abe Y, Suzuki M, Kimura H, Shimizu K, Makita H, Nishimura M, Konno S +6 moredoaj Longer Asthma Duration Is Associated With Elevated Non‐T2 Sputum Biomarkers and Reduced T2 Inflammation in Severe Asthma
Allergy, EarlyView.Longer asthma duration is associated with increased airway non‐T2 inflammation and reduced airway and systemic T2 inflammation. Sputum CXCL9 is independently associated with duration and may predict a reduced poor response to anti‐IL‐4Rα therapy. Airway sampling and combined T2 and non‐T2 targeted strategies may be needed in long‐standing asthma. CXCL9,Freda Yang, Sujin Seo, Takehiro Hasegawa, Chloe I. Bloom, Nazanin Zounemat‐Kermani, Pankaj K. Bhavsar, Katie Raby, Ian M. Adcock, Sungho Won, Tae‐Bum Kim, Kian Fan Chung, on behalf of the Unbiased Biomarkers for the Prediction of Respiratory Disease Outcomes (U‐BIOPRED) Consortium, M. I. Abdel‐Aziz, C. Auffray, Y. E. Badi, P. Bakke, A. T. Bansal, F. Baribaud, S. Bates, A. F. Behndig, E. H. Bel, J. Bigler, B. Billing, M. J. Boedigheimer, K. Bønnelykke, J. Brandsma, P. Brinkman, E. Bucchioni, D. Burg, A. Bush, M. Caruso, R. Chalekis, P. Chanez, B. Chaves, F. K. Chung, T. Checa, C. H. Compton, J. Corfield, D. Cunoosamy, A. D'Amico, B. Dahlén, B. De Meulder, R. Djukanovic, V. J. Erpenbeck, D. Erzen, K. Fichtner, L. J. Fleming, E. Formaggio, S. J. Fowler, U. Frey, M. Gahlemann, T. Geiser, V. Goss, Y. Guo, S. Hashimoto, J. Haughney, G. Hedlin, P. W. Hekking, T. Higenbottam, J. M. Hohlfeld, C. Holweg, I. Horváth, P. Howarth, A. J. James, R. G. Knowles, J. Kolmert, J. Konradsen, N. Krug, N. Lazarinis, C.‐X. Li, M. J. Loza, R. Lutter, A. Manta, S. Masefield, Maitland‐van der Zee Anke‐Hilse, J. G. Matthews, A. Mazein, R. J. M. Middelveld, M. Miralpeix, C. S. Murray, J. Musial, S. Mumby, D. Myles, B. Nordlund, H. Olsson, I. Pandis, S. Pavlidis, A. Platt, A. Postle, P. Powel, G. Praticò, M. Puig Valls, N. Rao, S. Reinke, J. Riley, A. Roberts, G. Roberts, A. Rowe, T. Sandström, J. P. R. Schofield, W. Seibold, D. E. Shaw, R. Sigmund, F. Singer, P. J. Skipp, M. Smicker, A. R. Sousa, M. Sparreman‐Mikus, P. J. Sterk, K. Sun, B. Thornton, A. Versi, N. H. Vissing, A. M. Wheelock, C. E. Wheelock, S. J. Wilson, V. Yasinska, Aliprantis Antonios, Allen David, Alving Kjell, P. Badorrek, Balgoma David, S. Ballereau, Barber Clair, Batuwitage Manohara Kanangana, Bautmans An, A. Bedding, A. F. Behndig, Beleta Jorge, A. Berglind, Bochenek Grazyna, Braun Armin, D. Campagna, Carayannopoulos Leon, C. Casaulta, A. Chaiboonchoe, Chaleckis Romanas, Davison Timothy, De Alba Jorge, Dekker Tamara, Delin Ingrid, P. Dennison, Dijkhuis Annemiek, Dodson Paul, Draper Aleksandra, K. Dyson, Edwards Jessica, L. El Hadjam, Emma Rosalia, C. Faulenbach, Flood Breda, G. Galffy, Gallart Hector, D. Garissi, J. Gent, M. Gerhardsson de Verdier, D. Gibeon, Gomez Cristina, Gove Kerry, Gozzard Neil, E. Guillmant‐Farry, E. Henriksson, Hewitt Lorraine, U. Hoda, Hu Richard, Hu Sile, X. Hu, E. Jeyasingham, K. Johnson, N. Jullian, Kamphuis Juliette, J. Kennington Erika, Kerry Dyson, G. Kerry, M. Klüglich, Knobel Hugo, J. Knox Alan, Kolmert Johan, J. R. Konradsen, Kots Maxim, Kretsos Kosmas, L. Krueger, Kuo Scott, Kupczyk Maciej, A.‐S Lantz, Larminie Christopher, L. X. Larsson, P. Latzin, N. Lazarinis, Lefaudeux Diane, N. Lemonnier, Li Chuan‐Xing, Lone‐Latif Saeeda, L. A. Lowe, Manta Alexander, Marouzet Lisa, Martin Jane, Mathon Caroline, L. McEvoy, Meah Sally, A. Menzies‐Gow, Metcalf Leanne, Meiser Andrea, Mikus Maria, Monk Philip, N. Mores, Naz Shama, K. Nething, Nicholas Ben, U. Nihlén, Nilsson Peter, R. Niven, B. Nordlund, S. Nsubuga, Pacino Antonio, Palkonen Susanna, L. Pahus, J. Pellet, Pennazza Giorgio, Petrén Anne, Pink Sandy, C. Pison, Rahman‐Amin Malayka, Ravanetti Lara, Ray Emma, Reinke Stacey, Reynolds Leanne, K. Riemann, Robberechts Martine, J. P. Rocha, C. Rossios, Russell Kirsty, Rutgers Michael, G. Santini, Santonico Marco, M. Saqi, Schoelch Corinna, S. Scott, N. Sehgal, A. Selby, Sjödin Marcus, Smids Barbara, Smith Caroline, Smith Jessica, M. Smith Katherine, P. Söderman, A. Sogbesan, F. Spycher, Staykova Doroteya, S. Stephan, J. Stokholm, K. Strandberg, M. Sunther, M. Szentkereszty, L. Tamasi, K. Tariq, Thörngren John‐Olof, Thorsen Jonathan, S. Valente, W. M. van Aalderen, Marianne van de Pol, C. M. van Drunen, Van Eyll Jonathan, Versnel Jenny, Vink Anton, C. von Garnier, A. Vyas, A. H. Wagener, Wald Frans, Walker Samantha, Ward Jonathan, Wetzel Kristiane, Wiegman Coen, Z. Weiszhart, Williams Siân, Yang Xian, Yeyasingham Elizabeth, W. Yu, W. Zetterquist, Z. Zolkipli, A. H. Zwinderman, Lega Italiano Anti Fumo, A. B. Aerocrine, N. V. Amgen, Merck Sharp, Martina Gahlemann, Luigi Visintin, Hazel Evans, Martine Puhl, Lina Buzermaniene, Val Hudson, Laura Bond, Pim de Boer, Guy Widdershoven, Ralf Sigmund, David Supple, Dominique Hamerlijnck, Jenny Negus, Juliёtte Kamphuis +298 morewiley +1 more source
