Results 71 to 80 of about 18,801 (261)

Hair analysis of formoterol as a novel tool to assess long‐term inhalation medication adherence: Data from the TRICOLON trial

British Journal of Clinical Pharmacology, EarlyView.
Aim The aim of this paper is to examine inhaled formoterol concentrations in hair and assess the potential of hair analysis as a tool for measuring long‐term adherence, by validation with objective data from digital inhalers. Methods Hair samples and digital inhaler data were collected from patients with COPD in 10 hospitals in the Netherlands as part ...
Liz J. A. Cuperus, A. Mireille A. Wessels, Huib A. M. Kerstjens, Daan J. Touw, Erik W. M. A. Bischoff, Job van der Palen, Arnoud Aldenkamp, Astrid van Huisstede, Folkert Brijker, Stephan Dik, Lidwien Graat‐Verboom, Martijn Goosens, Peter Th. W. van Hal, Jolanda C. Kuijvenhoven, Lisette I. Z. Kunz, Renske van der Meer, Mariette H. A. Scholma‐Bronsema, Job F. M. van Boven, Johannes C. C. M. in't Veen, the TRICOLON study group, Marjo van der Poel, Irini Piso, Marijke Amelink, Anke Rol, Jennifer de Graaf, Petra Hirmann, Fleur van Tour, Elly Jordens, Lydia Alfing, Gerda Lenderink, Truus Rietveld, Jasmijn van Campen, Jantine de Bruijn, Janice van ter Burg, Liselore Baarssmit, Walter van Litsenburg, Len Knoops, Margot Eggermont‐Schilt, Manon de Waard‐Heijligers, Ilonka Paalvast‐Schouten, Mariette Scholma, Sandra Brookman‐Mozes, Inge Paas, Lidwien Verboom, Karin van Mierlo‐Snoeijs   +44 more
wiley   +1 more source

Diagnostic Value of Fractional Exhaled Nitric Oxide and Small Airway Function in Differentiating Cough-Variant Asthma from Typical Asthma

Canadian Respiratory Journal, 2021
Purpose To explore the diagnostic value of fractional exhaled nitric oxide (FeNO), small airway function, and a combined of both in differentiating cough-variant asthma (CVA) from typical asthma (TA). Methods A total of 206 asthma subjects, including 104
Yanqi Wang, Lixuan Zhao, Fang Chen, Yufeng Guo, Hongxia Ma, Bao-fen Han, Jiang Yi, X. Kong   +7 more
semanticscholar   +1 more source

Pharmacokinetics and safety of tezepelumab in children with mild, moderate or severe asthma and adolescents with mild‐to‐moderate asthma

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Tezepelumab is a human monoclonal antibody that blocks the activity of thymic stromal lymphopoietin and is approved for adolescents and adults with severe asthma. This analysis assessed pharmacokinetics (PK), pharmacodynamics and safety of tezepelumab up to 85 days postdose in adolescents and children.
Anna Lundahl, Jonathan Grigg, Lubna Abuqayyas, Piotr Kuna, Gillian Hunter, Beata Pawlikowska, Jacob Leander, Michael Levin, Atul Gupta, James Paton, Katharine C. Pike, Jane R. Parnes, Gun Almqvist, Stephanie L. Roseti, on behalf of the study investigators   +14 more
wiley   +1 more source

Corticosteroid Exposure in Chronic Rhinosinusitis and Global Airway Disease: Adrenal and Bone Impact

The Laryngoscope, EarlyView.
ABSTRACT Objective To investigate cumulative corticosteroid (CC) burden in patients with chronic rhinosinusitis with nasal polyps (CRSwNP), with or without coexisting asthma (global airway disease, GAD), referred for biologic treatment, and to assess the prevalence of CC‐related comorbidities, including secondary adrenal insufficiency, osteopenia and ...
Christiane Haase, Kjell Erik Julius Håkansson, Peter Schwarz, Kasper Aanæs, Jens Tidemandsen, Charlotte Suppli. Ulrik, Bente Appel Esbensen, Vibeke Backer   +7 more
wiley   +1 more source

Measurement and Interpretation of Fractional Exhaled Nitric Oxide

The Korean Journal of Medicine, 2022
Nitric oxide is produced by the human lungs and increases in response to type 2 inflammation. The level of fractional exhaled nitric oxide (FeNO) may reflect type 2 inflammation in the airways, which is related to eosinophilic inflammation and treatment responsiveness to corticosteroids.
openaire   +1 more source

Chemical Ionization Mass Spectrometry: Fundamental Principles, Diverse Applications, and the Latest Technological Frontiers

Mass Spectrometry Reviews, EarlyView.
ABSTRACT The review examines the evolution of chemical ionization mass spectrometry (CI‐MS), a technique developed in 1966 by Field and Munson. CI is a soft‐ionization method that produces more intense molecular ions with less fragmentation than electron ionization (EI).
Malvika Dutt, Adriana Arigò, Giorgio Famiglini, Pierangela Palma, Achille Cappiello   +4 more
wiley   +1 more source

Silent zone detection in asthma and its relation to T2 inflammation

Egyptian Journal of Chest Disease and Tuberculosis
Objective Study objectives are to detect small airways disease in asthma and to study T2 inflammatory markers (eosinophil count, IgE, phenotyping) in association with small airways disease.
Hala Samaha, Dalia Elhassan, Afnan Tayeb
doaj   +1 more source

Personal Exposure to Black Carbon at School and Levels of Fractional Exhaled Nitric Oxide in New York City

Environmental Health Perspectives, 2021
Background: Schools are often located near traffic sources, leading to high levels of exposure to traffic-related air pollutants, including black carbon (BC). Thus, the school environment could play in a significant role in the adverse respiratory health
K. Jung, K. Goodwin, M. Perzanowski, S. Chillrud, F. Perera, Rachel L. Miller, Stephanie Lovinsky-Desir   +6 more
semanticscholar   +1 more source

Fractional Exhaled Nitric Oxide Measurements in Rhinitis and Asthma in Children [PDF]

International Journal of Immunopathology and Pharmacology, 2011
Exaled nitric oxide (FeNO) is considered a good noninvasive marker to assess airway inflammation in asthma and allergic rhinitis. In asthma, exhaled NO is very useful to verify adherence to therapy, and to predict upcoming asthma exacerbations. It has been also proposed that adjusting anti-inflammatory drugs guided by the monitoring of exhaled NO ...
Young Soo Shim, Ji Hwan Lim, Sang Min Lee, Choon Taek Lee, Sei Won Lee, Sei Won Lee, Chin Kook Rhee, Jieun Lee   +7 more
openaire   +5 more sources

Type‐2 airway inflammation in mild asthma patients with high blood eosinophils and high fractional exhaled nitric oxide

Clinical and Translational Science, 2021
Type‐2 (T2) inflammation is a characteristic feature of asthma. Biological therapies have been developed to target T2‐inflammation in asthma. IL‐13 is a key component of T2‐inflammation in asthma, driving mucus hypersecretion, IgE‐induction, and smooth ...
T. Southworth, M. van Geest, Dave Singh
semanticscholar   +1 more source