Results 91 to 100 of about 6,453 (193)

Impact of prednisolone tapering and extended dupilumab dosing intervals on comorbid asthma in patients with chronic rhinosinusitis with nasal polyps

Journal of Allergy and Clinical Immunology: Global
Background: Chronic rhinosinusitis with nasal polyps (CRSwNP) frequently coexists with asthma and involves type 2 inflammation. Dupilumab enables prednisolone (PSL) tapering and extended dosing intervals in CRSwNP, but the impact on comorbid asthma is ...
Shunsuke Minagawa, MD, PhD, Masahiro Yoshida, MD, PhD, Daiki Nakashima, MD, Takanori Numata, MD, PhD, Shun Inukai, MD, Tomoya Maruyama, MD, Tetsuya Adachi, MD, PhD, Jun Araya, MD, PhD, Yoshinori Matsuwaki, MD, PhD   +8 more
doaj   +1 more source

Inflammatory Mediators Associated With Corticosteroid Responsiveness During Asthma Attacks

Clinical &Experimental Allergy, EarlyView.
ABSTRACT Higher baseline sputum/serum eotaxin‐3 and serum IL‐5 levels were associated with greater FEV1 improvement following OCS during asthma attacks. Corticosteroid‐induced inflammatory modulation differed across T2 phenotypes during asthma attacks.
Carlos Celis‐Preciado, Elsa Ben Hamou Kuijpers, Mohamed‐Ilias Kourid, Simon Leclerc, Martine Duval, Dominic O. Cliche, Félix‐Antoine Vézina, Pierre Larivée, Samuel Lemaire‐Paquette, Philippe Lachapelle, Martin Klein, Simon Couillard   +11 more
wiley   +1 more source

Characterization and cluster analysis of Indian adults with asthma in the Vellore district

Journal of Allergy and Clinical Immunology: Global
Background: There is a huge burden of asthma in India, with an estimated 34.3 million patients comprising 13% of the global burden. Little is known about asthma phenotypes, endotypes, and clusters among native Indian patients.
Devasahayam Jesudas Christopher, DNB, Jefferson Daniel, MD, Glenis K. Scadding, MD, Adel H. Mansur, PhD, David Cameron Wraith, PhD, Rasiah Thayakaran, PhD, Mamidipudi Thirumala Krishna, PhD   +6 more
doaj   +1 more source

A new era beckons in asthma: enhanced models of care, disease remission, artificial intelligence and consumer participation

Internal Medicine Journal, EarlyView.
Abstract The landscape of asthma management is undergoing significant transformation. This change is driven by several factors: deeper understanding of asthma pathophysiology, appreciation of the long‐term harm of oral corticosteroids, biological treatments that dramatically improve patient outcomes with asthma remission becoming a realistic goal, and ...
John Politis, Kerry Hancock, Jo A Douglass, Paul Leong, Philip Bardin   +4 more
wiley   +1 more source

Differential effects of central blood volume loading and unloading on pulmonary diffusing capacity in humans

The Journal of Physiology, EarlyView.
Abstract figure legend Central blood volume (CBV) is a key haemodynamic determinant of pulmonary diffusing capacity for carbon monoxide (DLCO) and its components, capillary blood volume (Vc) and membrane diffusing capacity (Dm,CO). However the contribution of CBV to DLCO regulation remains poorly defined. We investigated the effects of graded increases
Andrew W. D'Souza, Andrew R. Brotto, Thomas G. Williams, Chuanyi Foo, Eli Bok, Desi P. Fuhr, Jason Weatherald, Sean van Diepen, Michael K. Stickland   +8 more
wiley   +1 more source

Tirzepatide and SGLT2 Inhibitors for Heart Failure With Preserved Ejection Fraction and Obesity: Entering a New Cardiometabolic Therapeutic Era

Endocrinology, Diabetes &Metabolism, Volume 9, Issue 5, September 2026.
Tirzepatide and SGLT2 inhibitors act through distinct but complementary mechanisms in obesity‐related HFpEF: tirzepatide targets adiposity, inflammation, and insulin resistance, while SGLT2 inhibitors improve decongestion, myocardial energetics, and cardiac remodeling.
Zakariye Isak Mohamed, Abdinasir Adam Shidane, Abdullahi Mohamud Abdiasis, Mohamed Hassan Hussein, Ayaanle Osman Ibrahim, Anas Ali Abdi, Kowthar Ismail Hashi, Mohamed Abdullahi Mohamud, Ali Jimale Mohamed   +8 more
wiley   +1 more source

Tezepelumab improved chronic rhinosinusitis with nasal polyps in a Patient with aspirin exacerbated respiratory disease

Respiratory Medicine Case Reports
Introduction: Patients with chronic rhinosinusitis with nasal polyps (CRSwNP) and aspirin-exacerbated respiratory disease (AERD) have more severe sinus disease than those without AERD.
Yuga Yamashita, Kosuke Terada, Yuka Kodama, Ryo Nakadegawa, Hinako Masumitsu, Yuto Motobayashi, Reeko Osada, Hirokazu Takayasu, Nami Masumoto, Takeshi Kaneko, Naomi Tsurikisawa   +10 more
doaj   +1 more source

Machine Learning‐Based Profiling of Urinary Volatile Organic Compounds Reveals Distinct Diagnostic Signatures for Gastric Cancer

Cancer Medicine, Volume 15, Issue 8, August 2026.
ABSTRACT Introduction Gastric cancer (GC) is a leading cause of cancer‐related mortality worldwide, often diagnosed at advanced stages due to the absence of specific symptoms. This study aimed to explore the potential of urinary volatile organic compounds (VOCs) as non‐invasive biomarkers for gastric cancer diagnosis.
Tao Sha, Wenyan Fei, Yun Zhao, Lin Bai
wiley   +1 more source

Improvement of Severe Volume Dependent Airway Closure With Tezepelumab: A Case Report

Clinical Case Reports, Volume 14, Issue 8, August 2026.
ABSTRACT Severe asthma may be complicated by airway remodeling, manifesting as higher symptom burden, airflow limitation and reduced treatment response. The effect of biologics on lung function changes remains uncertain. We report a 31‐year‐old man with severe uncontrolled asthma and chronic rhinosinusitis with nasal polyposis, characterized by ...
Philipp Suter, Robert Greig, Rory Chan, Brian J. Lipworth   +3 more
wiley   +1 more source

Corticosteroid Exposure in Chronic Rhinosinusitis and Global Airway Disease: Adrenal and Bone Impact

The Laryngoscope, Volume 136, Issue 8, Page 3398-3409, August 2026.
ABSTRACT Objective To investigate cumulative corticosteroid (CC) burden in patients with chronic rhinosinusitis with nasal polyps (CRSwNP), with or without coexisting asthma (global airway disease, GAD), referred for biologic treatment, and to assess the prevalence of CC‐related comorbidities, including secondary adrenal insufficiency, osteopenia and ...
Christiane Haase, Kjell Erik Julius Håkansson, Peter Schwarz, Kasper Aanæs, Jens Tidemandsen, Charlotte Suppli. Ulrik, Bente Appel Esbensen, Vibeke Backer   +7 more
wiley   +1 more source