Results 101 to 110 of about 111,080 (399)

Failed ISCHEMIA Trial or Failed Ischemia Testing? [PDF]

, 2020
The results of the ISCHEMIA (International Study of Comparative Health Effectiveness With Medical and Invasive Approach) trial were presented at the American Heart Association Scientific Sessions in November, 2019 in Philadelphia, Pennsylvania, and ...
Budoff, Matthew J, Dahal, Suraj
core  

Sex Differences in Computed Tomography Coronary Stenosis Severity Versus Flow Impairment and Impact on Revascularization, Clinical Events and Health Care Costs: A FORECAST Substudy

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background The impact of sex‐related differences in coronary atheroma and flow impairment severity on clinical events and costs remains unclear. Methods and Results This is a secondary analysis of patients with stable coronary artery disease who ...
Lavinia Gabara, Jonathan Hinton, Mohamed Kira, James Shambrook, Ausami Abbas, Sam Wilding, Jonathon A. Leipsic, Pamela S. Douglas, Nick Curzen   +8 more
doaj   +1 more source

FRACTIONAL FLOW RESERVE (FFR)

, 2015
FFR is a form of coronary artery measurement that provides valuable information about the functional significance of coronary artery blockade. It works on a simple hemodynamic principle that the more severe the blockade, the more would be the pressure drop beyond the blockade.
Mahajan, Neeraj, Kartik Patel
openaire   +2 more sources

The Potential for Extracellular Vesicles in Nanomedicine: A Review of Recent Advancements and Challenges Ahead

Advanced Biology, EarlyView.
Extracellular vesicles (EVs) play a dual role in diagnostics and therapeutics, offering innovative solutions for treating cancer, cardiovascular, neurodegenerative, and orthopedic diseases. This review highlights EVs’ potential to revolutionize personalized medicine through specific applications in disease detection and treatment.
Farbod Ebrahimi, Anjali Kumari, Samaneh Ghadami, Saqer Al Abdullah, Kristen Dellinger   +4 more
wiley   +1 more source

Utilization of translesional hemodynamics: comparison of pressure and flow methods in stenosis assessment in patie [PDF]

, 1996
Aim of this study is the assessment of feasibility and clinical usefulness of a new index of stenosis severity, the slope of the instantaneous transstenotic pressure gradient/velocity relationship.
Feyter, P.J. (Pim) de, Gil, R. (Robert), Mario, C. (Carlo) di, Schuurbiers, J.C.H. (Johan), Serruys, P.W.J.C. (Patrick)   +4 more
core  

Biomarkers of coronary endothelial health: correlation with invasive measures of collateral function, flow and resistance in chronically occluded coronary arteries and the effect of recanalization [PDF]

, 2016
Objectives: In the presence of a chronically occluded coronary artery, the collateral circulation matures by a process of arteriogenesis; however, there is considerable variation between individuals in the functional capacity of that collateral network ...
Alamgir, Farquad, Cunnington, Michael S., Ettelaie, Camille, Hoye, Angela, Ladwiniec, Andrew, Rossington, Jennifer, Thackray, Simon   +6 more
core   +1 more source

Investigating the Cellular Effects of GALC Dosing in Enzyme Replacement Therapy for Krabbe Disease Supports the Role of Nanomedicine

Advanced Biology, EarlyView.
A detailed workflow for recombinant GALC production and characterization is presented to support enzyme replacement therapy for Krabbe disease. In vitro assays demonstrate that physiological GALC doses restore enzymatic activity and autophagic flux without affecting cell viability, whereas higher doses impair autophagy and reduce viability.
Ambra Del Grosso, Sara Carpi, Laura Colagiorgio, Miriam De Sarlo, Mariacristina Gagliardi, Marco Cecchini   +5 more
wiley   +1 more source

Stable coronary syndromes: pathophysiology, diagnostic advances and therapeutic need [PDF]

, 2018
The diagnostic management of patients with angina pectoris typically centres on the detection of obstructive epicardial CAD, which aligns with evidence-based treatment options that include medical therapy and myocardial revascularisation.
Berry, Colin, Corcoran, David, Ford, Thomas J.   +2 more
core   +1 more source

Invasive physiological indices to determine the functional significance of coronary stenosis

International Journal of Cardiology: Heart & Vasculature, 2018
Physiological measurements are now commonly used to assess coronary lesions in the cardiac catheterisation laboratory, and this practice is evidence-based and supported by clinical guidelines. Fractional flow reserve is currently the gold standard method
Firas R. AL-Obaidi, William F. Fearon, Andy S.C. Yong   +2 more
doaj  

Functional assessment of coronary stenosis: alternative hyperemic, nonhyperemic, and angiographic indexes

REC: Interventional Cardiology (English Ed.)
Assessment of the functional significance of coronary artery stenoses to guide percutaneous coronary intervention is widely performed using pressure wire fractional flow reserve during adenosine- or adenosine triphosphate-induced hyperemia.
Federico Vergni, Giuliano Fiore, Francesco Pellone, Mario Luzi   +3 more
doaj   +1 more source