Results 81 to 90 of about 55,652 (297)

Functional assessment of coronary stenosis: alternative hyperemic, nonhyperemic, and angiographic indexes

open access: yesREC: Interventional Cardiology (English Ed.)
Assessment of the functional significance of coronary artery stenoses to guide percutaneous coronary intervention is widely performed using pressure wire fractional flow reserve during adenosine- or adenosine triphosphate-induced hyperemia.
Federico Vergni   +3 more
doaj   +1 more source

Utilization of translesional hemodynamics: comparison of pressure and flow methods in stenosis assessment in patie [PDF]

open access: yes, 1996
Aim of this study is the assessment of feasibility and clinical usefulness of a new index of stenosis severity, the slope of the instantaneous transstenotic pressure gradient/velocity relationship.
Feyter, P.J. (Pim) de   +4 more
core  

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

open access: yesMolecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova   +14 more
wiley   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

open access: yesMolecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera   +11 more
wiley   +1 more source

Free Banking, the Real-Balance Effect, and Walras´ Law [PDF]

open access: yes, 2008
The author of this article draws special attention to two particular claims of the free bankers concerning the supposed working characteristics of a fractional-reserve free banking system which may strike the reader as questionable.
van den Hauwe, Ludwig
core   +5 more sources

Impact of incomplete ventricular coverage on diagnostic performance of myocardial perfusion imaging. [PDF]

open access: yes, 2017
In the context of myocardial perfusion imaging (MPI) with cardiac magnetic resonance (CMR), there is ongoing debate on the merits of using technically complex acquisition methods to achieve whole-heart spatial coverage, rather than conventional 3-slice ...
Arsanjani, Reza   +8 more
core   +1 more source

Motorized fractional flow reserve pullback: Accuracy and reproducibility

open access: yesCatheterization and Cardiovascular Interventions, 2020
AbstractObjectivesThe present study aimed at determining the accuracy and reproducibility of motorized FFR pullbacks in patients with stable coronary artery disease.BackgroundFractional flow reserve (FFR) is recommended for decision making regarding myocardial revascularization.
Sonck J.   +9 more
openaire   +5 more sources

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

open access: yesMolecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu   +10 more
wiley   +1 more source

The future of ischemic stroke: flow from prehospital neuroprotection to definitive reperfusion. [PDF]

open access: yes, 2014
Recent advances in ischemic stroke enable a seamless transition of the patient flow from the prehospital setting to definitive reperfusion, without the arbitrary separation of therapeutic phases of ischemia based on time alone.
Ip, Hing Lung, Liebeskind, David S
core   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

open access: yesMolecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen   +9 more
wiley   +1 more source

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