Results 61 to 70 of about 56,087 (349)

Is it the Time to Move Towards Coronary Computed Tomography Angiography-Derived Fractional Flow Reserve Guided Percutaneous Coronary Intervention? The Pros and Cons. [PDF]

, 2023
Coronary artery disease is the leading cause of mortality worldwide. Diagnosis is conventionally performed by direct visualization of the arteries by invasive coronary angiography (ICA), which has inherent limitations and risks. Measurement of fractional
Hooshanginezhad, Zahra, Shamsa, Kamran, Sharifkazemi, Mohammadbagher, Zoroufian, Arezou   +3 more
core   +1 more source

Targeted metabolomics reveals novel diagnostic biomarkers for colorectal cancer

Molecular Oncology, EarlyView.
This study employed targeted metabolomic profiling to identify 302 distinct metabolites present in platelet‐rich plasma (PRP), revealing aberrant metabolic profiles amongst individuals diagnosed with colorectal cancer (CRC). Compared to carcinoembryonic antigen (CEA) and cancer antigen 19‐9 (CA199), our metabolite panel showed improved sensitivity ...
Zuojian Hu, Fenglin Shen, Yang Liu, Ziqing Zhong, Yongling Chen, Zhiyuan Xia, Cuiju Mo, Hongxiu Yu   +7 more
wiley   +1 more source

DIAGNOSTIC ACCURACY OF FFRACTIONAL FLOW RESERVE IN DIAGNOSING STENTABLE INTERMEDIATE STENOSIS IN PATIENTS OF CORONARY ARTERY DISEASE KEEPING ANGIOGRAPHY AS A GOLD STANDARD

Pakistan Armed Forces Medical Journal, 2020
Objective: To determine diagnostic accuracy of fractional flow reserve in diagnosing stentable intermediate stenosis in patients of coronary artery disease keeping angiography as gold standard. Study Design: Cross sectional validation study.
Abid Saeed, Muhammad Fareed, Abid Sharif, Salma Younas, Fatima Gul   +4 more
doaj  

Fractional flow reserve in patients with reduced ejection fraction

European Heart Journal, 2019
Abstract Aims Fractional flow reserve (FFR) has never been investigated in patients with reduced ejection fraction and associated coronary artery disease (CAD). We evaluated the impact of FFR on the management strategies of these patients and related outcomes.
Giuseppe Di Gioia, Bernard De Bruyne, Mariano Pellicano, Jozef Bartunek, Iginio Colaiori, Antonella Fiordelisi, Grazia Canciello, Panagiotis Xaplanteris, Stephane Fournier, Asim Katbeh, Danilo Franco, Monika Kodeboina, Carmine Morisco, Frank Van Praet, Filip Casselman, Ivan Degrieck, Bernard Stockman, Marc Vanderheyden, Emanuele Barbato   +18 more
openaire   +4 more sources

Etoposide‐induced cancer cell death: roles of mitochondrial VDAC1 and calpain, and resistance mechanisms

Molecular Oncology, EarlyView.
The complex mode of action of the topoisomerase II inhibitor etoposide in triggering apoptosis involves several mechanisms: overexpression of the mitochondrial protein VDAC1, leading to its oligomerization and formation of a large channel that mediates the release of pro‐apoptotic protein; and overexpression of the apoptosis regulators p53, Bax, and ...
Aditya Karunanithi Nivedita, Varda Shoshan‐Barmatz   +1 more
wiley   +1 more source

Respiratory complex I‐mediated NAD+ regeneration regulates cancer cell proliferation through the transcriptional and translational control of p21Cip1 expression by SIRT3 and SIRT7

Molecular Oncology, EarlyView.
NAD+ regeneration by mitochondrial complex I NADH dehydrogenase is important for cancer cell proliferation. Specifically, NAD+ is necessary for the activities of NAD+‐dependent deacetylases SIRT3 and SIRT7, which suppress the expression of p21Cip1 cyclin‐dependent kinase inhibitor, an antiproliferative molecule, at the translational and transcriptional
Masato Higurashi, Kazunori Mori, Hidetsugu Nakagawa, Momoko Uchida, Fumihiro Ishikawa, Motoko Shibanuma   +5 more
wiley   +1 more source

Relationship Between Endothelial Wall Shear Stress and High‐Risk Atherosclerotic Plaque Characteristics for Identification of Coronary Lesions That Cause Ischemia: A Direct Comparison With Fractional Flow Reserve

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2016
BackgroundWall shear stress (WSS) is an established predictor of coronary atherosclerosis progression. Prior studies have reported that high WSS has been associated with high‐risk atherosclerotic plaque characteristics (APCs).
Donghee Han, Anna Starikov, Bríain ó Hartaigh, Heidi Gransar, Kranthi K. Kolli, Ji Hyun Lee, Asim Rizvi, Lohendran Baskaran, Joshua Schulman‐Marcus, Fay Y. Lin, James K. Min   +10 more
doaj   +1 more source

End-Diastolic Fractional Flow Reserve [PDF]

Circulation: Cardiovascular Interventions, 2014
Background— Diastolic fractional flow reserve (dFFR) has been shown to be highly sensitive for detection of inducible myocardial ischemia. However, its reliance on measurement of left-ventricular pressure for zero-flow pressure correction, as well as manual extraction of the diastolic interval, has been its major limitation ...
David A. Chalyan, Sabee Molloi, Shigeho Takarada, Zhang Zhang   +3 more
openaire   +3 more sources

Peripheral blood proteome biomarkers distinguish immunosuppressive features of cancer progression

Molecular Oncology, EarlyView.
Immune status significantly influences cancer progression. This study used plasma proteomics to analyze benign 67NR and malignant 4T1 breast tumor models at early and late tumor stages. Immune‐related proteins–osteopontin (Spp1), lactotransferrin (Ltf), calreticulin (Calr) and peroxiredoxin 2 (Prdx2)–were associated with systemic myeloid‐derived ...
Yeon Ji Park, Jae Won Oh, Hyewon Chung, Jung Won Kwon, Yi Rang Na, Kwang Pyo Kim, Seung Hyeok Seok   +6 more
wiley   +1 more source

Role of measurement of fractional flow reserve in coronary artery atherosclerosis

Терапевтический архив, 2015
The paper considers coronary flow in health and coronary flow autoregulation in health and disease. It gives basic methods used to estimate coronary flow reserve in patients with coronary atherosclerosis.
F Yu Kopylov, A A Bykova, Yu V Vasilevsky, S S Simakov   +3 more
doaj