Results 41 to 50 of about 18,576 (289)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

DIAGNOSTIC ACCURACY OF FFRACTIONAL FLOW RESERVE IN DIAGNOSING STENTABLE INTERMEDIATE STENOSIS IN PATIENTS OF CORONARY ARTERY DISEASE KEEPING ANGIOGRAPHY AS A GOLD STANDARD

open access: yesPakistan Armed Forces Medical Journal, 2020
Objective: To determine diagnostic accuracy of fractional flow reserve in diagnosing stentable intermediate stenosis in patients of coronary artery disease keeping angiography as gold standard. Study Design: Cross sectional validation study.
Abid Saeed   +4 more
doaj  

Should fractional flow reserve follow angiographic visual inspection to guide preventive percutaneous coronary intervention in ST-elevation myocardial infarction?

open access: yes, 2020
This is a pre-copyedited, author-produced version of an article accepted for publication in Cardiovascular Research following peer review. The version of record David S Wald, FRCP, Steven Hadyanto, BSc, Jonathan P Bestwick, MSc, Should Fractional Flow ...
Bestwick, JP, Wald, DS, Hadyanto, S
core   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Functional assessment in acute coronary syndrome: a systematic review of acute versus staged interventions

open access: yesREC: Interventional Cardiology (English Ed.)
Introduction and objectives: Several tools have been implemented to assess the functional significance of coronary lesions. Their reliability in the management of acute coronary syndrome (ACS) might be affected by alterations in the acute phase that go ...
Federico Vergni   +5 more
doaj   +1 more source

Capabilities of Modern Semiconductor Gamma Cameras in Radionuclide Diagnosis of Coronary Artery Disease

open access: yesDiagnostics, 2021
This paper presents a review of the literature concerning the clinical application of modern semiconductor (CZT) gamma cameras in the radioinuclide diagnosis of coronary artery disease.
Michał Błaszczyk   +2 more
doaj   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

open access: yesFEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil   +4 more
wiley   +1 more source

Heart transplant coronary artery disease: Multimodality approach in percutaneous intervention

open access: yesRevista Portuguesa de Cardiologia, 2016
Coronary artery disease is the most important cause of late morbidity and mortality after heart transplantation. It is usually an immunologic phenomenon termed cardiac allograft vasculopathy, but can also be the result of donor-transmitted ...
Luís Leite   +7 more
doaj   +1 more source

Dynamics of Myocardial Remodeling Activity Markers in Patients with Myocardial Infarction with Persistent ST-Segment Elevation on the Background of Multivascular Coronary Artery Disease Depending on Diagnostic and Treatment Tactics

open access: yesУкраїнський журнал серцево-судинної хірургії, 2021
In patients with myocardial infarction with stable ST-segment elevation, the gold standard is to perform emergency angiography and stenting of the infarct-dependent artery.
D. Yu. Uzun   +2 more
doaj   +1 more source

Artificial intelligence approaches to predict coronary stenosis severity using non-invasive fractional flow reserve [PDF]

open access: yes, 2020
Fractional flow reserve is the current reference standard in the assessment of the functional impact of a stenosis in coronary heart disease. In this study, three models of artificial intelligence of varying degrees of complexity were compared to ...
Jason M. Carson   +3 more
core   +1 more source

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