Results 71 to 80 of about 227,281 (268)

Certain new weighted estimates proposing generalized proportional fractional operator in another sense

Advances in Difference Equations, 2020
The present work investigates the applicability and effectiveness of generalized proportional fractional integral ( GPFI $\mathcal{GPFI}$ ) operator in another sense.
Thabet Abdeljawad, Saima Rashid, A. A. El-Deeb, Zakia Hammouch, Yu-Ming Chu   +4 more
doaj   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Certain Inequalities Involving Generalized Erdélyi-Kober Fractional q-Integral Operators

The Scientific World Journal, 2014
In recent years, a remarkably large number of inequalities involving the fractional q-integral operators have been investigated in the literature by many authors.
Praveen Agarwal, Soheil Salahshour, Sotiris K. Ntouyas, Jessada Tariboon   +3 more
doaj   +1 more source

Some results on quantum Hahn integral inequalities

Journal of Inequalities and Applications, 2019
In this paper the quantum Hahn difference operator and the quantum Hahn integral operator are defined via the quantum shift operator Φqθ(t)=qt+(1−q)θ $_{\theta }\varPhi _{q}(t)=qt+(1-q)\theta $, t∈[a,b] $t\in [a,b]$, θ=ω/(1−q)+a $\theta = \omega /(1-q)+a$
Suphawat Asawasamrit, Chayapat Sudprasert, Sotiris K. Ntouyas, Jessada Tariboon   +3 more
doaj   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

On applications of Caputo k-fractional derivatives

Advances in Difference Equations, 2019
This research explores Caputo k-fractional integral inequalities for functions whose nth order derivatives are absolutely continuous and possess Grüss type variable bounds. Using Chebyshev inequality (Waheed et al. in IEEE Access 7:32137–32145, 2019) for
Ghulam Farid, Naveed Latif, Matloob Anwar, Ali Imran, Muhammad Ozair, Madeeha Nawaz   +5 more
doaj   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Some new inequalities for generalized fractional conformable integral operators

Advances in Difference Equations, 2019
The present paper aims to establish certain new classes of integral inequalities for a class of n ( n∈N $n\in \mathbb{N}$) positive continuous and decreasing functions by utilizing the generalized fractional conformable integral operators (FCIO) recently
Kottakkaran Sooppy Nisar, Gauhar Rahman, Aftab Khan   +2 more
doaj   +1 more source