Results 61 to 70 of about 227,281 (268)
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Solving Undamped and Damped Fractional Oscillators via Integral Rohit Transform
Al-Mustansiriyah Journal of ScienceBackground: The dynamics of fractional oscillators are generally described by fractional differential equations, which include the fractional derivative of the Caputo or Riemann-Liouville type.
Rohit Gupta, Rahul Gupta, Dinesh Verma
doaj +1 more source
ON GENERALIZED FRACTIONAL INTEGRALS
Taiwanese Journal of Mathematics, 2001 The author introduces generalized fractional integrals and extends the Hardy-Littlewood-Sobolev theorem to Orlicz spaces. He also investigates the boundedness of generalized fractional integrals from Orlicz spaces to \(\text{BMO}_\varphi(\mathbb{R}^n)\) and from \(\text{BMO}_\varphi(\mathbb{R}^n)\) to \(\text{BMO}_\psi(\mathbb{R}^n)\), where \(\text ...
openaire +4 more sources
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Fractional integral inequalities and global solutions of fractional differential equations
Electronic Journal of Qualitative Theory of Differential Equations, 2020 New fractional integral inequalities are established, which generalize some famous inequalities. Then we apply these new fractional integral inequalities to study global existence results for fractional differential equations.
Tao Zhu
doaj +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane
FEBS Letters, EarlyView.Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa +3 more
wiley +1 more source
Abstract and Applied Analysis, 2014 A remarkably large number of integral transforms and fractional integral formulas involving various special functions have been investigated by many authors.
Junesang Choi, Praveen Agarwal
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The Minkowski inequality involving generalized k-fractional conformable integral
Journal of Inequalities and Applications, 2019 In the research paper, the authors exploit the definition of a new class of fractional integral operators, recently proposed by Jarad et al. (Adv. Differ. Equ.
Shahid Mubeen +2 more
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pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source