Results 81 to 90 of about 4,622 (261)
Directed evolution of enzymes at the crossroads of tradition and innovation
FEBS Open Bio, EarlyView.An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova +2 more
wiley +1 more source
Variable Herz Estimates for Fractional Integral Operators
Ukrainian Mathematical Journal, 2020 UDC 517.5 In this paper, the author study the boundedness of fractional integral operators on a variable Herz-type Hardy space by using the atomic decomposition.
openaire +1 more source
Small RNA pathways in mammalian oocytes
FEBS Open Bio, EarlyView.Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley +1 more source
Two-weight norm inequalities for the rough fractional integrals
International Journal of Mathematics and Mathematical Sciences, 2001 The authors give the weighted (Lp,Lq)-boundedness of the rough fractional integral operator TΩ,α and the fractional maximal operator MΩ,α with two different weight functions.
Yong Ding, Chin-Cheng Lin
doaj +1 more source
Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA
FEBS Open Bio, EarlyView.PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro +1 more
wiley +1 more source
FEBS Open Bio, EarlyView.The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley +1 more source
Solving General Differential Equations of Fractional Orders Via Rohit Transform [PDF]
Kirkuk Journal of Scienceinspecting the attributes of derivatives and integrals of fractional orders known as fractional derivatives and integrals. In this article, a far-out complex integral transform known as the Rohit transform (RT) is put into use for working out general ...
Rohit Gupta, Rahul Gupta, Dinesh Verma
doaj +1 more source
FEBS Open Bio, EarlyView.Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill +6 more
wiley +1 more source
Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface
FEBS Open Bio, EarlyView.HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana +5 more
wiley +1 more source
Some new applications of the fractional integral and four-parameter Mittag-Leffler function.
PLoS ONEThe article reveals new applications of the four-parameter Mittag-Leffler function (MLF) in geometric function theory (GFT), using fractional calculus notions.
Ahmad A Abubaker +3 more
doaj +1 more source