Results 61 to 70 of about 4,622 (261)

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

The Extended Bessel-Maitland Function and Integral Operators Associated with Fractional Calculus

Journal of Mathematics, 2020
The aim of this paper is to introduce a presumably and remarkably altered integral operator involving the extended generalized Bessel-Maitland function. Particular properties are considered for the extended generalized Bessel-Maitland function connected ...
Kelelaw Tilahun, Hagos Tadessee, D. L. Suthar   +2 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Some Results of R-Matrix Functions and Their Fractional Calculus

Fractal and Fractional
In this study, we explore various fractional integral properties of R-matrix functions using the Hilfer fractional derivative operator within the framework of fractional calculus.
Mohra Zayed, Ahmed Bakhet
doaj   +1 more source

On Mikusinski's operators of fractional integration

, 1975
In the field F of convolution quotients,  b∝ is the operator of integration of fractional order ∝ and b∝ f   Is the Riemann - Liouville integral of order   ∝ of f. In this paper we give a generalization of this operator, which is denoted as b∝,va . Some particular cases are mentioned and the inverse operator is obtained.
Batting, A., Kalla, S. L.
openaire   +2 more sources

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Some estimations on continuous random variables for (k, s) −fractional integral operators

Moroccan Journal of Pure and Applied Analysis, 2020
In this work, we establish some new (k, s) −fractional integral inequalities of continuous random variables by using the (k, s) −Riemann-Liouville fractional integral operator.
Houas Mohamed
doaj   +1 more source

Quadruple integral equations and operators of fractional integration [PDF]

Glasgow Mathematical Journal, 1971
Cooke [1] modified a technique used by Erdelyi and Sneddon [2] to solve triple integral equations of a certain type. In this paper, we extend this method to solve the quadruple integral equationswhere F1, G2, F3 and G4 are prescribed functions of p and ψ(ξ) is to be determined. With no loss of generality we shall assume that G2(p)≡0, G4(p)≡0.
openaire   +2 more sources