Results 61 to 70 of about 93,896 (272)

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Riemann–Liouville Operator in Weighted L_p Spaces via the Jacobi Series Expansion

Axioms, 2019
In this paper, we use the orthogonal system of the Jacobi polynomials as a tool to study the Riemann−Liouville fractional integral and derivative operators on a compact of the real axis.
Maksim V. Kukushkin
doaj   +1 more source

New estimates considering the generalized proportional Hadamard fractional integral operators

Advances in Difference Equations, 2020
In the article, we describe the Grüss type inequality, provide some related inequalities by use of suitable fractional integral operators, address several variants by utilizing the generalized proportional Hadamard fractional (GPHF) integral operator. It
Shuang-Shuang Zhou, Saima Rashid, Fahd Jarad, Humaira Kalsoom, Yu-Ming Chu   +4 more
doaj   +1 more source

Generalized integral inequalities for ABK-fractional integral operators

AIMS Mathematics, 2021
في هذه الورقة، نوظف إصدارًا جديدًا من مشغل Atangana - Baleanu المتكامل وهو تكامل كسري بقيمة $ ABK $ للحصول على هويتين متكاملتين عامتين تمتثلان لمشتقات من الدرجة الثانية لوظيفة معينة. مما يسمح لنا باشتقاق متباينات جديدة معممة من نوع Hermite - Hadamard عبر التكاملات الجزئية $ ABK $.
Saad Ihsan Butt, Erhan Set, Saba Yousaf, Thabet Abdeljawad, Wasfı Shatanawi   +4 more
openaire   +3 more sources

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Studying changes in the dynamical patterns in two physical models involving new Caputo operator

Journal of Advanced Research
Introduction: Studying phase changes in physical models enables researchers to adequately describe the dynamics arising from such systems. Objectives: This work investigates the effect of a new Caputo fractional operator on the dynamics in two physical ...
A.E. Matouk
doaj   +1 more source

Muckenhoupt–Wheeden conjectures for fractional integral operators

Journal of Mathematical Analysis and Applications, 2017
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Yoshihiro Sawano, Satoko Sugano, Hitoshi Tanaka   +2 more
openaire   +1 more source

Fractional Type Integral Operators on Variable Hardy Spaces [PDF]

Acta Mathematica Hungarica, 2014
We study the boundedness of certain fractional integral operators from Hp(.) into Lq(.). We also obtain the Hp(.)- Hq(.) boundedness of the Riesz potential.
Rocha, P., Urciuolo, M.
openaire   +3 more sources

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Variable Herz Estimates for Fractional Integral Operators

Ukrainian Mathematical Journal, 2020
UDC 517.5 In this paper, the author study the boundedness of fractional integral operators on a variable Herz-type Hardy space by using the atomic decomposition.
openaire   +1 more source