Results 71 to 80 of about 93,896 (272)

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

The Extended Bessel-Maitland Function and Integral Operators Associated with Fractional Calculus

Journal of Mathematics, 2020
The aim of this paper is to introduce a presumably and remarkably altered integral operator involving the extended generalized Bessel-Maitland function. Particular properties are considered for the extended generalized Bessel-Maitland function connected ...
Kelelaw Tilahun, Hagos Tadessee, D. L. Suthar   +2 more
doaj   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Compactness of Riemann–Liouville fractional integral operators

Electronic Journal of Qualitative Theory of Differential Equations, 2020
Summary: We obtain results on compactness of two linear Hammerstein integral operators with singularities, and apply the results to give new proof that Riemann-Liouville fractional integral operators of order \(\alpha\in (0,1)\) map \(L^{p}(0,1)\) to \(C[0,1]\) and are compact for each \(p\in \bigl(\frac{1}{1-\alpha},\infty\bigr]\).
openaire   +3 more sources

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Some Results of R-Matrix Functions and Their Fractional Calculus

Fractal and Fractional
In this study, we explore various fractional integral properties of R-matrix functions using the Hilfer fractional derivative operator within the framework of fractional calculus.
Mohra Zayed, Ahmed Bakhet
doaj   +1 more source

Some estimations on continuous random variables for (k, s) −fractional integral operators

Moroccan Journal of Pure and Applied Analysis, 2020
In this work, we establish some new (k, s) −fractional integral inequalities of continuous random variables by using the (k, s) −Riemann-Liouville fractional integral operator.
Houas Mohamed
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Multilinear fractional integral operators: a counter-example

Annales Academiae Scientiarum Fennicae Mathematica, 2020
By means of a counter-example we show that the multilinear fractional operator is not bounded from a product of Hardy spaces into a Hardy space.
openaire   +3 more sources