Results 71 to 80 of about 4,622 (261)

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

open access: yesMolecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

On Some Grüss-Type Fractional Inequalities Using Saigo Fractional Integral Operator

open access: yesJournal of Mathematics, 2014
The main aim of this paper is to establish some new fractional integral inequalities of Grüss-type via the Saigo fractional integral operator.
Vaijanath L. Chinchane   +1 more
doaj   +1 more source

On positive solutions of a system of equations generated by Hadamard fractional operators

open access: yesAdvances in Difference Equations, 2020
This paper is devoted to studying some systems of quadratic differential and integral equations with Hadamard-type fractional order integral operators.
Amira M. Abdalla   +2 more
doaj   +1 more source

Cancer cell‐intrinsic type 1 interferon: production, signaling, and outcomes within sex‐biased, female malignancies

open access: yesMolecular Oncology, EarlyView.
The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant   +7 more
wiley   +1 more source

Refinements of Pólya-SzegŐ and Chebyshev type inequalities via different fractional integral operators

open access: yesHeliyon
Various differential and integral operators have been introduced and applied for the generalization of several integral inequalities. The purpose of this article is to create a more generalized fractional integral operator of Saigo type.
Ayyaz Ahmad, Matloob Anwar
doaj   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

open access: yesFEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz   +6 more
wiley   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

open access: yesFEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei   +3 more
wiley   +1 more source

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

open access: yesFEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento   +6 more
wiley   +1 more source

The Normalized Prabhakar Fractional Operator’s Boundedness Across Various Spaces

open access: yesInternational Journal of Mathematics and Mathematical Sciences
A functional space called the Bloch space is made up of analytic functions on the unit disk in the complex plane. These functions provide a number of benefits and intriguing characteristics, as well as meeting specific growth requirements. In this notice,
Rabha W. Ibrahim
doaj   +1 more source

Some New Tempered Fractional Pólya-Szegö and Chebyshev-Type Inequalities with Respect to Another Function

open access: yesJournal of Mathematics, 2020
In this present article, we establish certain new Pólya–Szegö-type tempered fractional integral inequalities by considering the generalized tempered fractional integral concerning another function Ψ in the kernel. We then prove certain new Chebyshev-type
Gauhar Rahman   +3 more
doaj   +1 more source

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