Results 61 to 70 of about 3,783 (264)

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Inequalities for B $\mathbb{B}$-convex functions via generalized fractional integral

Journal of Inequalities and Applications, 2019
Recently, fractional calculus has become a very popular and important area. Specially, fractional integral inequalities have been studied by different authors.
Ilknur Yesilce
doaj   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Statistical Distribution Theory and Fractional Calculus

Stats
This is an overview paper. This paper is an attempt to show that fractional calculus can be reached through statistical distribution theory. This paper brings together results on fractional integrals and fractional derivatives of the first and second ...
A. M. Mathai
doaj   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

On an Inequality of H. G. Hardy

Journal of Inequalities and Applications, 2010
We state, prove, and discuss new general inequality for convex and increasing functions. As a special case of that general result, we obtain new fractional inequalities involving fractional integrals and derivatives of Riemann-Liouville type ...
Krulić Kristina, Iqbal Sajid, Pečarić Josip   +2 more
doaj  

Generalized Fractional ρ,k,φ-Proportional Hilfer Derivatives and Some Properties

Journal of Mathematics
Building on previous work in fractional calculus, this paper introduces new definitions for the ρ,k,φ-proportional integral and ρ,k,φ-proportional H fractional derivative.
Haihua Wang
doaj   +1 more source

Inequalities Pertaining Fractional Approach through Exponentially Convex Functions

Fractal and Fractional, 2019
In this article, certain Hermite-Hadamard-type inequalities are proven for an exponentially-convex function via Riemann-Liouville fractional integrals that generalize Hermite-Hadamard-type inequalities.
Saima Rashid, Muhammad Aslam Noor, Khalida Inayat Noor   +2 more
doaj   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source