Results 81 to 90 of about 1,437,498 (311)

Cell density–dependent nuclear‐cytoplasmic shuttling of SETDB1 integrates with Hippo signaling to regulate YAP1‐mediated transcription

FEBS Letters, EarlyView.
At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom, Jaewoong Jang, Jung Sun Park, Yong‐Kook Kang   +3 more
wiley   +1 more source

Generalized Riemann-Liouville $k$ -Fractional Integrals Associated With Ostrowski Type Inequalities and Error Bounds of Hadamard Inequalities

IEEE Access, 2018
Ostrowski inequality provides the estimation of a function to its integral mean. It is useful in error estimations of quadrature rules in numerical analysis.
Y. Kwun, G. Farid, W. Nazeer, Sami Ullah, S. Kang   +4 more
semanticscholar   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

Partial, Composite Fractional Operators, and Their Properties and Applications

MATEC Web of Conferences, 2017
The paper discusses the properties of the partial fractional integrals, the partial fractional derivatives, and the composite fractional integrals and derivatives.
Deng Kaiying, Deng Jingwei, Li Suduo
doaj   +1 more source

Certain inequalities via generalized proportional Hadamard fractional integral operators

Advances in Difference Equations, 2019
In the article, we introduce the generalized proportional Hadamard fractional integrals and establish several inequalities for convex functions in the framework of the defined class of fractional integrals.
Gauhar Rahman, Thabet Abdeljawad, Fahd Jarad, Aftab Khan, Kottakkaran Sooppy Nisar   +4 more
doaj   +1 more source

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira, Anna Skwarska, Karolina Chwialkowska, Agnieszka Ostrowska, Gabriela Sokolowska, Anna Zeller, Anna Erol, Andrzej Eljaszewicz, Bartosz Hanczaruk, Anna Michalska‐Falkowska, Agnieszka Tarasik, Joanna Reszec‐Gielazyn, Pawel Knapp, Marcin Moniuszko, Adam Kretowski   +14 more
wiley   +1 more source

On Hermite-Hadamard type inequalities for Riemann-Liouville fractional integrals

, 2017
In this paper, we have established Hermite-Hadamard-type inequalities for fractional integrals and will be given an identity. With the help of this fractional-type integral identity, we give some integral inequalities connected with the left-side of ...
M. Sarıkaya, H. Yildirim
semanticscholar   +1 more source

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source

Fractional Cauchy Problem with Riemann-Liouville Fractional Delta Derivative on Time Scales

Abstract and Applied Analysis, 2013
The Δ-power function and fractional Δ-integrals and fractional Δ-differential are defined, and then the definitions and properties of Δ-Mittag-Leffler function are given.
Jiang Zhu, Ying Zhu
doaj   +1 more source