Results 91 to 100 of about 61,286 (267)

Cytomegalovirus infection is common in prostate cancer and antiviral therapies inhibit progression in disease models

Molecular Oncology, EarlyView.
Human cytomegalovirus infection is common in normal prostate epithelium, prostate tumor tissue, and prostate cancer cell lines. CMV promotes cell survival, proliferation, and androgen receptor signaling. Anti‐CMV pharmaceutical compounds in clinical use inhibited cell expansion in prostate cancer models in vitro and in vivo, motivating investigation ...
Johanna Classon, Moa Stenudd, Margherita Zamboni, Kanar Alkass, Carl‐Johan Eriksson, Lars Pedersen, Alrik Schörling, Anna Thoss, Anders Bergh, Pernilla Wikström, Hans‐Olov Adami, Henrik Toft Sørensen, Henrik Druid, Jonas Frisén   +13 more
wiley   +1 more source

D1-D5-P microstates at the cap

, 2013
The geometries describing D1-D5-P bound states in string theory have three regions: flat asymptotics, an anti-de Sitter throat, and a 'cap' region at the bottom of the throat.
Giusto, Stefano, Lunin, Oleg, Mathur, Samir D., Turton, David   +3 more
core   +1 more source

On Local Fractional Topological Indices and Entropies for Hyper-Chordal Ring Networks Using Local Fractional Metric Dimension

Symmetry
An algebraic graph is defined in terms of graph theory as a graph with related algebraic structures or characteristics. If the vertex set of a graph G is a group, a ring, or a field, then G is called an algebraic structure graph. This work uses an algebraic structure graph based on the modular ring Zn, known as a hyper-chordal ring network.
Shahzad Ali, Shahzaib Ashraf, Shahbaz Ali, Abdullah Afzal, Amal S. Alali   +4 more
openalex   +2 more sources

Exploring the role of cyclin D1 in the pathogenesis of multiple myeloma beyond cell cycle regulation

Molecular Oncology, EarlyView.
Cyclin D1 overexpression altered the cell adhesion pathway, while cyclin D2 upregulation had less impact on pathway enrichment analysis. Multiple myeloma (MM) patients with cyclin D1 overexpression showed reduced CD56 expression and increased circulating tumor cells (CTC) levels, suggesting that cyclin D1 may contribute to MM cell dissemination ...
Ignacio J. Cardona‐Benavides, Sara Cristobal‐Vargas, Cristina De Ramón, Elizabeta A. Rojas, Irena Misiewicz‐Krzeminska, Isabel Isidro, José Juan Pérez, Bruno Paiva, Noemi Puig, Miguel Alcoceba, María‐Victoria Mateos, Luis A. Corchete, Myriam Cuadrado, Norma C. Gutiérrez   +13 more
wiley   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Functional, but minimal microstructural brain changes present in aging Canadian football league players years after retirement

Brain Disorders, 2022
This brain imaging study examined subjects with a history of repetitive concussive and sub-concussive impacts sustained over the course of their careers in the Canadian Football League (CFL).
Ethan Danielli, Nicholas Simard, Bhanu Sharma, Mitchell Doughty, Michael D. Noseworthy   +4 more
doaj  

Fractional Systems and Fractional Bogoliubov Hierarchy Equations

, 2005
We consider the fractional generalizations of the phase volume, volume element and Poisson brackets. These generalizations lead us to the fractional analog of the phase space.
A. A. Vlasov, A. Isihara, B. A. Dubrovin, B. Mandelbrot, D. Ya. Petrina, I. P. Kornfeld, J. C. Collins, K. P. Gurov, M. Schroeder, N. Bogolybow, N. N. Bogoliubov, N. N. Bogoliubov, N. N. Bogoliubov, P. Debye, S. G. Samko, T. F. Nonnenmacher, V. E. Tarasov, V. E. Tarasov, V. E. Tarasov, Vasily E. Tarasov   +19 more
core   +1 more source

Unveiling unique protein and phosphorylation signatures in lung adenocarcinomas with and without ALK, EGFR, and KRAS genetic alterations

Molecular Oncology, EarlyView.
Proteomic and phosphoproteomic analyses were performed on lung adenocarcinoma (LUAD) tumors with EGFR, KRAS, or EML4–ALK alterations and wild‐type cases. Distinct protein expression and phosphorylation patterns were identified, especially in EGFR‐mutated tumors. Key altered pathways included vesicle transport and RNA splicing.
Fanni Bugyi, Mirjam Balbisi, Simon Sugár, Lóránd Váncza, Eszter Regős, Ilona Kovalszky, Ibolya Laczó, Tünde Harkó, Gábor Kecskeméti, Zoltán Szabó, Judit Moldvay, László Drahos, Lilla Turiák   +12 more
wiley   +1 more source

The Einstein Relation on Metric Measure Spaces

, 2019
This note is based on F. Burghart's master thesis at Stuttgart university from July 2018, supervised by Prof. Freiberg. We review the Einstein relation, which connects the Hausdorff, local walk and spectral dimensions on a space, in the abstract ...
Burghart, Fabian, Freiberg, Uta
core  

Single‐cell transcriptomics redefines focal neuroendocrine differentiation as a distinct prostate cancer pathology

Molecular Oncology, EarlyView.
Single‐cell transcriptomics of prostate cancer patient‐derived xenografts reveals distinct features of neuroendocrine (NE) subtypes. Tumours with focal NE differentiation (NED) share transcriptional programmes with adenocarcinoma, differing from large and small cell neuroendocrine prostate cancer (NEPC). Our work defines the molecular landscape of NEPC,
Rosalia Quezada Urban, Shivakumar Keerthikumar, Ashlee Clark, Hong Wang, Belinda Phipson, Andrew Bakshi, Andrew Ryan, Heather Thorne, Renea A. Taylor, Mitchell G. Lawrence, Gail P. Risbridger, Roxanne Toivanen, David L. Goode   +12 more
wiley   +1 more source