Results 81 to 90 of about 177,034 (253)
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
An extension problem for the CR fractional Laplacian [PDF]
, 2013 We show that the conformally invariant fractional powers of the sub-Laplacian on the Heisenberg group are given in terms of the scattering operator for an extension problem to the Siegel upper halfspace.
Frank, Rupert L. +3 more
core +2 more sources
Midisuperspace quantization: possibilities for fractional and emergent spacetime dimensions
, 2016 Recently, motivated by certain loop quantum gravity inspired corrections, it was shown that for spherically symmetric midisuperspace models infinitely many second derivative theories of gravity exist (as revealed by the presence of three arbitrary ...
Tibrewala, Rakesh
core +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
FQHE on curved backgrounds, free fields and large N
, 2014 We study the free energy of the Laughlin state on curved backgrounds, starting from the free field representation. A simple argument, based on the computation of the gravitational effective action from the transformation properties of Green functions ...
Ferrari, Frank, Klevtsov, Semyon
core +1 more source
From fractional Lane-Emden-Serrin equation -- existence, multiplicity and local behaviors via classical ODE -- to fractional Yamabe metrics with singularity of "maximal" dimension [PDF]
, 2021 Hardy Chan, Azahara DelaTorre
openalex +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Fractional $K$-Clique Metric Dimension of (Edge) Corona Products of Graphs
The Art of Discrete and Applied MathematicsZeinab Shahmiri +2 more
openalex +2 more sources