Results 91 to 100 of about 177,034 (253)
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Some sample path properties of multifractional Brownian motion
, 2014 The geometry of the multifractional Brownian motion (mBm) is known to present a complex and surprising form when the Hurst function is greatly irregular.
Balança, Paul
core +3 more sources
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source
, 2016 We show explicitly that the full structure of IIB string theory is needed to remove the non-localities that arise in boundary conformal theories that border hyperbolic spaces on AdS$_5$.
La Nave, Gabriele, Phillips, Philip W.
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Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
IEEE AccessFractional metric parameters were introduced to address linear programming optimization problems and thereby have application in telecommunication, computer networking and linear optimization theory.
Faiza Jamil +4 more
doaj +1 more source
Fractional Almost Kahler - Lagrange Geometry
, 2010 The goal of this paper is to encode equivalently the fractional Lagrange dynamics as a nonholonomic almost Kahler geometry. We use the fractional Caputo derivative generalized for nontrivial nonlinear connections (N-connections) originally introduced in ...
Baleanu, Dumitru, Vacaru, Sergiu I.
core +1 more source
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source
The Einstein Relation on Metric Measure Spaces
, 2019 This note is based on F. Burghart's master thesis at Stuttgart university from July 2018, supervised by Prof. Freiberg. We review the Einstein relation, which connects the Hausdorff, local walk and spectral dimensions on a space, in the abstract ...
Burghart, Fabian, Freiberg, Uta
core