Results 81 to 90 of about 61,286 (267)

Black holes in multi-fractional and Lorentz-violating models [PDF]

, 2017
We study static and radially symmetric black holes in the multi-fractional theories of gravity with $q$-derivatives and with weighted derivatives, frameworks where the spacetime dimension varies with the probed scale and geometry is characterized by at ...
Calcagni, Gianluca, Fernández, David Rodríguez, Ronco, Michele   +2 more
core   +4 more sources

Determination of ADP/ATP translocase isoform ratios in malignancy and cellular senescence

Molecular Oncology, EarlyView.
The individual functions of three isoforms exchanging ADP and ATP (ADP/ATP translocases; ANTs) on the mitochondrial membrane remain unclear. We developed a method for quantitatively differentiating highly similar human ANT1, ANT2, and ANT3 using parallel reaction monitoring. This method allowed us to assess changes in translocase levels during cellular
Zuzana Liblova, Dominika Maurencova, Barbora Salovska, Marek Kratky, Tomas Mracek, Zuzana Korandova, Alena Pecinova, Pavla Vasicova, David Rysanek, Ladislav Andera, Ivo Fabrik, Rudolf Kupcik, Pavel Kashmel, Pinky Sultana, Vojtech Tambor, Jiri Bartek, Josef Novak, Marie Vajrychova, Zdenek Hodny   +18 more
wiley   +1 more source

Early metastasis is characterized by Gr1+ cell dysregulation and is inhibited by immunomodulatory nanoparticles

Molecular Oncology, EarlyView.
Breast cancer metastasis is associated with myeloid cell dysregulation and the lung‐specific accumulation of tumor‐supportive Gr1+ cells. Gr1+ cells support metastasis, in part, through a CHI3L1‐mediated mechanism, which can be targeted and inhibited with cargo‐free, polymeric nanoparticles.
Jeffrey A. Ma, Sophia M. Orbach, Kate V. Griffin, Kathryn Kang, Yining Zhang, Rebecca S. Pereles, Ian A. Schrack, Guillermo Escalona, Jacqueline S. Jeruss, Lonnie D. Shea   +9 more
wiley   +1 more source

Fractional Almost Kahler - Lagrange Geometry

, 2010
The goal of this paper is to encode equivalently the fractional Lagrange dynamics as a nonholonomic almost Kahler geometry. We use the fractional Caputo derivative generalized for nontrivial nonlinear connections (N-connections) originally introduced in ...
Baleanu, Dumitru, Vacaru, Sergiu I.
core   +1 more source

The anticancer effect of the HDAC inhibitor belinostat is enhanced by inhibitors of Bcl‐xL or Mcl‐1 in ovarian cancer

Molecular Oncology, EarlyView.
The pan‐HDAC inhibitor belinostat increases the expression of the pro‐apoptotic proteins Bim, Puma, and Noxa and induces apoptosis in ovarian cancer cell lines and patient‐derived tumor organoids when used at high concentrations. Moreover, inhibiting the anti‐apoptotic proteins Bcl‐xL or Mcl‐1 sensitizes these preclinical models to the cytotoxic effect
Cécilia Thomine, Sterenn Guillemot, Louis‐Bastien Weiswald, Romane Florent, Edwige Abeilard, Florence Giffard, Emilie Brotin, Mélanie Briand, Enora Dolivet, Laurent Poulain, Marie Villedieu   +10 more
wiley   +1 more source

Distance-Based Fractional Dimension of Certain Wheel Networks

Journal of Mathematics
Metric dimension is one of the distance-based parameters which are used to find the position of the robot in a network space by utilizing lesser number of notes and minimum consumption of time. It is also used to characterize the chemical compounds.
Hassan Zafar, Muhammad Javaid, Mamo Abebe Ashebo   +2 more
doaj   +1 more source

Spinning and rotating strings for N=1 SYM theory and brane constructions

, 2003
We obtain spinning and rotating closed string solutions in AdS_5 \times T^{1,1} background, and show how these solutions can be mapped onto rotating closed strings embedded in configurations of intersecting branes in type IIA string theory.
A. Armoni, A. Armoni, A. Buchel, A. Hashimoto, A.A. Tseytlin, A.M. Uranga, B. Andreas, D. Aleksandrova, D. Aleksandrova, D. Berenstein, D. Mateos, D. Youm, D.J. Gross, D.J. Gross, E. D'Hoker, E. Witten, G.P. Korchemsky, I.R. Klebanov, J.G. Russo, J.M. Maldacena, J.P. Gauntlett, K. Dasgupta, K. Ohta, K.H. Oh, Kazutoshi Ohta, M. Alishahiha, M. Alishahiha, M. Kruczenski, M. Kruczenski, Martin Schvellinger, N. Beisert, N. Beisert, P. Ouyang, R. Iengo, R. Iengo, R.C. Rashkov, S. Frolov, S. Frolov, S. Ryang, S.A. Hartnoll, S.S. Gubser, T. Sakai, U. Gursoy   +42 more
core   +1 more source

Systematic profiling of cancer‐fibroblast interactions reveals drug combinations in ovarian cancer

Molecular Oncology, EarlyView.
Fibroblasts, cells in the tumor environment, support ovarian cancer cell growth and alter morphology and drug response. We used fibroblast and cancer cell co‐culture models to test 528 drugs and discovered new drugs for combination treatment. We showed that adding Vorinostat or Birinapant to standard chemotherapy may improve drug response, suggesting ...
Greta Gudoityte, Osheen Sharma, Laura Leuenberger, Emelie Wallin, Josefin Fernebro, Päivi Östling, Rebecka Bergström, Johan Lindberg, Ulrika Joneborg, Olli Kallioniemi, Brinton Seashore‐Ludlow   +10 more
wiley   +1 more source

Anyon Black Holes

, 2018
We propose a correspondence between an Anyon Van der Waals fluid and a (2+1) dimensional AdS black hole. Anyons are particles with intermediate statistics that interpolates between a Fermi-Dirac statistics and a Bose-Einstein one.
Abchouyeh, Maryam Aghaei, Mirza, Behrouz, Takrami, Moein Karimi, Younesizadeh, Younes   +3 more
core   +1 more source

A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner

Molecular Oncology, EarlyView.
We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp, Wouter P. R. Verdurmen, Jonas V. Schaefer, Kari Kopra, Gabriela Nagy‐Davidescu, Elodie Richard, Marie‐Julie Nokin, Patrick Ernst, Rastislav Tamaskovic, Martin Schwill, Ralph Degen, Claudia Scholl, David Santamaria, Andreas Plückthun   +13 more
wiley   +1 more source