Results 101 to 110 of about 16,663 (301)

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

open access: yesFEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei   +3 more
wiley   +1 more source

A Study of Composition Formulas for the Unified Fractional Integral Operators

open access: yes, 2015
[[abstract]]In the present paper we derive three new and interesting composition formulas for a general class of fractional integral operators involving the product of a general class of polynomials, a general sequence of functions and a multivariable H ...
Sharma, Arti, Jain, Rashmi
core  

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

open access: yesFEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane   +11 more
wiley   +1 more source

On a certain fractional operator

open access: yesProceedings of the Japan Academy, Series A, Mathematical Sciences, 1991
Let \(S:*(\alpha),\;K(\alpha)\) be the class of starlike and convex functions of order \(\alpha\), analytic in the open unit disk. Define the convolution of \(f_ 1 * f_ 2 (z)=\sum:\infty_{n=0} a_{1,n+1}a_{2,n+1}z:{n+1},\;f_ i (z)= \sum:{\infty}_{n=0}a_{i,n+1}z:{n+1},\;i=1,\;2.\) Let \((\lambda)_ n\) be the Pochhammer symbol defined by \((\lambda)_ 0=1,\
Owa, Shigeyoshi   +2 more
openaire   +2 more sources

Fractional operators and applications to fractional martingal

open access: yesInternational Journal of Advances in Applied Mathematics and Mechanics, 2018
Summary: In this paper, we use the fractional operators for to give the fractional martingale properties. We give again some examples.
openaire   +2 more sources

Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10

open access: yesFEBS Open Bio, EarlyView.
Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee   +6 more
wiley   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

open access: yesFEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho   +4 more
wiley   +1 more source

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

open access: yesFEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento   +6 more
wiley   +1 more source

A Local Fractional Variational Iteration Method for Laplace Equation within Local Fractional Operators

open access: yesAbstract and Applied Analysis, 2013
The local fractional variational iteration method for local fractional Laplace equation is investigated in this paper. The operators are described in the sense of local fractional operators. The obtained results reveal that the method is very effective.
Yong-Ju Yang   +2 more
doaj   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

open access: yesFEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova   +2 more
wiley   +1 more source

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