Results 91 to 100 of about 261,053 (323)

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui   +6 more
wiley   +1 more source

Effective Method for Solving Different Types of Nonlinear Fractional Burgers’ Equations

open access: yesMathematics, 2020
In this study, a relatively new method to solve partial differential equations (PDEs) called the fractional reduced differential transform method (FRDTM) is used. The implementation of the method is based on an iterative scheme in series form.
Safyan Mukhtar   +3 more
doaj   +1 more source

Fractional-Parabolic Systems [PDF]

open access: yes, 2012
We develop a theory of the Cauchy problem for linear evolution systems of partial differential equations with the Caputo-Dzrbashyan fractional derivative in the time variable $t$.
Kochubei, Anatoly N.
core  

An Analysis of the Modified L1 Scheme for Time-Fractional Partial Differential Equations with Nonsmooth Data

open access: yesSIAM Journal on Numerical Analysis, 2018
We introduce a modified L1 scheme for solving time fractional partial differential equations and obtain error estimates for smooth and nonsmooth initial data in both homogeneous and inhomogeneous cases. Jin, Lazarov, and Zhou [IMA J. Numer.
Yubin Yan, Monzorul Khan, N. Ford
semanticscholar   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

open access: yesMolecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son   +13 more
wiley   +1 more source

Homotopy Perturbation Method Combined with ZZ Transform to Solve Some Nonlinear Fractional Differential Equations

open access: yesInternational Journal of Analysis and Applications, 2019
The idea proposed in this work is to extend the ZZ transform method to resolve the nonlinear fractional partial differential equations by combining them with the so-called homotopy perturbation method (HPM).
Lakhdar Riabi   +3 more
doaj   +2 more sources

Vector Additive Decomposition for 2D Fractional Diffusion Equation

open access: yesNonlinear Analysis, 2008
Such physical processes as the diffusion in the environments with fractal geometry and the particles’ subdiffusion lead to the initial value problems for the nonlocal fractional order partial differential equations. These equations are the generalization 
N. Abrashina-Zhadaeva, N. Romanova
doaj   +1 more source

Domain decomposition methods for space fractional partial differential equations [PDF]

open access: yesJournal of Computational Physics, 2017
In this paper, a two-level additive Schwarz preconditioner is proposed for solving the algebraic systems resulting from the finite element approximations of space fractional partial differential equations (SFPDEs). It is shown that the condition number of the preconditioned system is bounded by C(1+H/δ), where H is the maximum diameter of subdomains ...
Jiang, Yingjun, Xu, Xuejun
openaire   +3 more sources

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

open access: yesMolecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto   +8 more
wiley   +1 more source

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