Results 41 to 50 of about 8,873,429 (247)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Solution of fractional modified Kawahara equation: a semi-analytic approach

Mathematics in Applied Sciences and Engineering, 2023
The present study examines a semi-analytical method known as the Fractional Residual Power Series Method for obtaining solutions to the non-linear, time-fractional Kawahara and modified Kawahara equations.
Sagar Khirsariya, Snehal Rao, Jignesh Chauhan   +2 more
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Limits of Some Fractional Power Exponential Functions

, 2022
: In this article, we study the limit problems of some fractional power exponential functions. Jumarie type of Riemann-Liouville (R-L) fractional derivative, fractional L’Hospital’s rule, and a new multiplication of fractional analytic functions play ...
Chii-Huei Yu
core   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Solving Nonlinear Fractional PDEs with Applications to Physics and Engineering Using the Laplace Residual Power Series Method

International Journal of Differential Equations, 2023
The Laplace residual power series (LRPS) method uses the Caputo fractional derivative definition to solve nonlinear fractional partial differential equations. This technique has been applied successfully to solve equations such as the fractional Kuramoto–
Khalid K. Ali, F. E. Abd Elbary, Mohamed S. Abdel-Wahed, M. A. Elsisy, Mourad S. Semary   +4 more
doaj   +1 more source

Identification of (20R)‐protopanaxadiol from Panax ginseng as a novel anti‐SARS‐CoV‐2 compound

FEBS Open Bio, EarlyView.
We established a noninfectious BAC‐based SARS‐CoV‐2 replicon that enables antiviral screening under BSL‐2 conditions. Using this platform, we screened 373 food‐derived compounds and identified (20R)‐protopanaxadiol from Panax ginseng as a novel inhibitor of SARS‐CoV‐2 RNA replication, highlighting the value of safe replicon systems for antiviral ...
Midori Takeda, Natsue Maezono, Rina Uchikoshi, Nobuyuki Kato, Masanori Ikeda   +4 more
wiley   +1 more source

Fractional View Study of the Brusselator Reaction–Diffusion Model Occurring in Chemical Reactions

Fractal and Fractional, 2023
In this paper, we study a fractional Brusselator reaction–diffusion model with the help of the residual power series transform method. Specific reaction–diffusion chemical processes are modeled by applying the fractional Brusselator reaction–diffusion ...
Saleh Alshammari, M. Mossa Al-Sawalha, Jamal R. Humaidi   +2 more
doaj   +1 more source

Comparative assessment of crystallographic and cryo‐EM models in the Protein Data Bank

FEBS Open Bio, EarlyView.
Raw data obtained by X‐ray crystallography or cryo‐EM result in experimental maps, ultimately fitted by atomic models. Although the physical principles are different, the final results can be viewed, compared, and evaluated in the same way. With cryogenic electron microscopy (cryo‐EM) on track to surpass X‐ray crystallography as the preferred method ...
Alexander Wlodawer, Pawel Rubach, Zbigniew Dauter, Wojciech Dec, Dariusz Brzezinski, Marta Kulik, Wladek Minor, Mariusz Jaskolski   +7 more
wiley   +1 more source

Numerical investigation of two-dimensional fuzzy fractional heat problem with an external source variable.

PLoS ONE
This study suggests a strategy for calculating the fuzzy analytical solutions to a two-dimensional fuzzy fractional-order heat problem including a diffusion variable connected externally.
Muhammad Nadeem, Saad H Alotaibi, Fawziah M Alotaibi, Yahya Alsayaad   +3 more
doaj   +1 more source