Results 51 to 60 of about 8,668,074 (299)

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

open access: yesFEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang   +4 more
wiley   +1 more source

Necessary optimality conditions for fractional action-like problems with intrinsic and observer times [PDF]

open access: yes, 2008
We prove higher-order Euler-Lagrange and DuBois-Reymond stationary conditions to fractional action-like variational problems.
Frederico, G.S.F., Torres, D.F.M.
core   +1 more source

The effects of treatment with melatonin on the ultrastructure of mouse leydig cells: a quantitative study [PDF]

open access: yesBrazilian Journal of Biology, 2002
Both the presence of receptors for gonadal steroids in the pineal gland and in vitro observations of direct action of melatonin upon Leydig cells, inhibiting testosterone secretion, indicate a direct connection between pineal gland and gonadal function ...
C. A. REDINS, G. M. REDINS, J. C. NOVAES
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

open access: yesFEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee   +2 more
wiley   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

open access: yesFEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante   +10 more
wiley   +1 more source

Optimizing Fractional Intensity Threshold for FSLBrain Extraction Tool (BET) and Comparing with FreeSurfer on 3D T1W MR Images

open access: yesSiriraj Medical Journal, 2018
Objective: To find out the optimal Brain Extraction Tool (BET) parameter (fractional intensity threshold) for measuring the brain volume compared with the standard manual method in our institute and to compare with those of automated FreeSurfer software ...
Yudthaphon Vichianin, Ph.D.   +3 more
doaj   +3 more sources

Gray and White Matter Contributions to Cognitive Frontostriatal Deficits in Non-Demented Parkinson's Disease.

open access: yesPLoS ONE, 2016
ObjectiveThis prospective investigation examined: 1) processing speed and working memory relative to other cognitive domains in non-demented medically managed idiopathic Parkinson's disease, and 2) the predictive role of cortical/subcortical gray ...
Catherine C Price   +9 more
doaj   +1 more source

Dual-energy micro-CT functional imaging of primary lung cancer in mice using gold and iodine nanoparticle contrast agents: a validation study. [PDF]

open access: yesPLoS ONE, 2014
PURPOSE:To provide additional functional information for tumor characterization, we investigated the use of dual-energy computed tomography for imaging murine lung tumors. Tumor blood volume and vascular permeability were quantified using gold and iodine
Jeffrey R Ashton   +6 more
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

open access: yesFEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass   +2 more
wiley   +1 more source

A Mixed Finite Volume Element Method for Time-Fractional Damping Beam Vibration Problem

open access: yesFractal and Fractional, 2022
In this paper, the transverse vibration of a fractional viscoelastic beam is studied based on the fractional calculus, and the corresponding scheme of a viscoelastic beam is established by using the mixed finite volume element method.
Tongxin Wang   +3 more
doaj   +1 more source

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