Results 101 to 110 of about 339,529 (309)

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Fractional systems and fractional Bogoliubov hierarchy equations [PDF]

Physical Review E, 2005
We consider the fractional generalizations of the phase volume, volume element and Poisson brackets. These generalizations lead us to the fractional analog of the phase space. We consider systems on this fractional phase space and fractional analogs of the Hamilton equations. The fractional generalization of the average value is suggested.
openaire   +3 more sources

REE fractionation during granite weathering and removal by waters and suspended loads: Sr and Nd isotopic evidence [PDF]

, 2001
Very few studies deal with REE (rare earth element) mobility within the system soil–soil solution–streamwater. In this article, we try to characterize the fractionation and the migration of the REE in a granite-derived soil system located in a small ...
Dominique Aubert, Aubert, Dominique, Anne Probst, Stille, Peter, Probst, Anne, Peter Stille   +5 more
core   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Experimental study on isotope fractionation effects in visible photolysis of O3 and in the O + O3 odd oxygen sink reaction [PDF]

, 2015
International audienceInvestigation of isotope effects in ozone (O3) photolysis and its contribution to the overall ozone isotope composition is difficult since photolysis always leads to secondary O3 formation and O3 decomposition by reactions with O(3P)
Früchtl,, Marion, Janssen, Christof, Janssen,, Christof, Röckmann, Thomas, Sub Atmospheric physics and chemistry, Marion Früchtl, Marine and Atmospheric Research, Roeckmann, T., Christof Janssen, Fruechtl, M., Thomas Röckmann   +10 more
core   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Advection-dispersion in symmetric field-flow fractionation channels [PDF]

, 1998
We model the evolution of the concentration field of macromolecules in a symmetric field-flow fractionation (FFF) channel by a one-dimensional advection-diffusion equation. The coefficients are precisely determined from the fluid dynamics.
Roberts, A. J., Suslov, Sergey A.
core   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source