Results 71 to 80 of about 347,722 (310)

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Advances in Research on Uranium Isotope Fraction in Nature and Prospects

He huaxue yu fangshe huaxue, 2022
Uranium is the heaviest naturally occurring radioactive element in nature, and it is widely distributed in the earth’s crust. With the improvement of the technical accuracy of mass spectrometry to measure uranium isotope ratios, it is gradually ...
SONG Jing, TAN Kai-xuan, LIU Zhen-zhong, LI Chun-guang, LI Yong-mei, WENG Zong-xiang   +5 more
doaj   +1 more source

Fractional coalescent [PDF]

Proceedings of the National Academy of Sciences, 2019
An approach to the coalescent, the fractional coalescent ( f -coalescent), is introduced. The derivation is based on the discrete-time Cannings population model in which the variance of the number of ...
Mashayekhi, Somayeh, Beerli, Peter
openaire   +2 more sources

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

The Effect of the Time Interval Between Radiation and Hyperthermia on Clinical Outcome in 400 Locally Advanced Cervical Carcinoma Patients

Frontiers in Oncology, 2019
Background: Addition of deep hyperthermia to radiotherapy results in improved local control (LC) and overall survival compared to radiotherapy alone in cervical carcinoma patients.
M. Kroesen, H. T. Mulder, J. M. L. van Holthe, A. A. Aangeenbrug, J. W. M. Mens, H. C. van Doorn, M. M. Paulides, M. M. Paulides, E. Oomen-de Hoop, R. M. Vernhout, L. C. Lutgens, G. C. van Rhoon, M. Franckena   +12 more
doaj   +1 more source

Inequality and Fractionalization [PDF]

World Development, 2010
We present evidence that ethnic fragmentation explains variations in per capita income, institutions, and schooling better than income inequality when both are treated as endogenous. To do so, we identify instruments for ethnic fractionalization and income inequality based on historical experience.
Gregory P. Casey, Ann L. Owen
openaire   +2 more sources

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Factors affecting cadmium toxicity to rice germinated in soils collected from downstream areas of abandoned zinc mines [PDF]

Global Journal of Environmental Science and Management
BACKGROUND AND OBJECTIVES: Cadmium contamination in rice grains with a maximum concentration 19 times the national food standard at sites downstream of zinc mines in Thailand has been reported since 2005.
P. Chanpiwat, A. Numprasanthai
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source