Results 11 to 20 of about 1,721,489 (338)

Mechanosensitive Piezo1 is crucial for periosteal stem cell-mediated fracture healing

International Journal on Biological Sciences, 2022
The biomechanical environment plays a dominant role in fracture healing, and Piezo1 is regarded as a major mechanosensor in bone homeostasis. However, the role of Piezo1 in fracture healing is not yet well characterized.
Yunlu Liu, H. Tian, Yuxiang Hu, Yulin Cao, Huijuan Song, Shenghui Lan, Zhipeng Dai, Wei Chen, Yingze Zhang, Zengwu Shao, Yong Liu, W. Tong   +11 more
semanticscholar   +1 more source

Gait Analysis to Monitor Fracture Healing of the Lower Leg

Bioengineering, 2023
Fracture healing is typically monitored by infrequent radiographs. Radiographs come at the cost of radiation exposure and reflect fracture healing with a time lag due to delayed fracture mineralization following increases in stiffness.
Elke Warmerdam, Marcel Orth, Tim Pohlemann, Bergita Ganse   +3 more
doaj   +1 more source

Age-associated callus senescent cells produce TGF-β1 that inhibits fracture healing in aged mice

Journal of Clinical Investigation, 2022
Cellular senescence plays an important role in human diseases, including osteoporosis and osteoarthritis. Senescent cells (SCs) produce the senescence-associated secretory phenotype to affect the function of neighboring cells and SCs themselves.
Jiatong Liu, Jun Zhang, Xi Lin, B. Boyce, Hengwei Zhang, L. Xing   +5 more
semanticscholar   +1 more source

Implantable Electrical Stimulation at Dorsal Root Ganglions Accelerates Osteoporotic Fracture Healing via Calcitonin Gene‐Related Peptide

Advancement of science, 2021
The neuronal engagement of the peripheral nerve system plays a crucial role in regulating fracture healing, but how to modulate the neuronal activity to enhance fracture healing remains unexploited.
Jie Mi, Jian-Kun Xu, Zhi Yao, Hao Yao, Ye Li, X. He, Bingyang Dai, Li Zou, Wenxue Tong, Xiaotian Zhang, Peijie Hu, Y. Ruan, Ning Tang, Xia Guo, Jie Zhao, Junhui He, L. Qin   +16 more
semanticscholar   +1 more source

A self-powered implantable and bioresorbable electrostimulation device for biofeedback bone fracture healing

Proceedings of the National Academy of Sciences of the United States of America, 2021
Significance Bone fracture represents a significant problem in public health. State-of-the-art clinical study demonstrated that by correlating the stimulation amplitude and frequency directly to dynamic locomotion, biofeedback electrostimulation therapy ...
Guang Yao, Lei Kang, Cuicui Li, Sihong Chen, Qian Wang, Junzhe Yang, Yin Long, Jun Li, Kangning Zhao, Weina Xu, W. Cai, Yuan Lin, Xudong Wang   +12 more
semanticscholar   +1 more source

Simulation-based prediction of bone healing and treatment recommendations for lower leg fractures: Effects of motion, weight-bearing and fibular mechanics

Frontiers in Bioengineering and Biotechnology, 2023
Despite recent experimental and clinical progress in the treatment of tibial and fibular fractures, in clinical practice rates of delayed bone healing and non-union remain high.
Marcel Orth, Bergita Ganse, Bergita Ganse, Annchristin Andres, Kerstin Wickert, Elke Warmerdam, Max Müller, Stefan Diebels, Michael Roland, Tim Pohlemann   +9 more
doaj   +1 more source

Joint Cartilage in Long-Duration Spaceflight

Biomedicines, 2022
This review summarizes the current literature available on joint cartilage alterations in long-duration spaceflight. Evidence from spaceflight participants is currently limited to serum biomarker data in only a few astronauts.
Bergita Ganse, Magali Cucchiarini, Henning Madry   +2 more
doaj   +1 more source

miR-19b enhances osteogenic differentiation of mesenchymal stem cells and promotes fracture healing through the WWP1/Smurf2-mediated KLF5/β-catenin signaling pathway

Experimental and Molecular Medicine, 2021
Bone marrow mesenchymal stem cell (BMSC)-derived exosomes have been found to enhance fracture healing. In addition, microRNAs contributing to the healing of various bone fractures have attracted widespread attention in recent years, but knowledge of the ...
Yan Huang, Yongqiang Xu, Siyin Feng, Pan He, Bin Sheng, Jiangdong Ni   +5 more
semanticscholar   +1 more source

Effects of age, body height, body weight, body mass index and handgrip strength on the trajectory of the plantar pressure stance-phase curve of the gait cycle

Frontiers in Bioengineering and Biotechnology, 2023
The analysis of gait patterns and plantar pressure distributions via insoles is increasingly used to monitor patients and treatment progress, such as recovery after surgeries.
Christian Wolff, Patrick Steinheimer, Elke Warmerdam, Tim Dahmen, Philipp Slusallek, Christian Schlinkmann, Fei Chen, Marcel Orth, Tim Pohlemann, Bergita Ganse, Bergita Ganse   +10 more
doaj   +1 more source

A Deep Learning Approach for Gait Event Detection from a Single Shank-Worn IMU: Validation in Healthy and Neurological Cohorts

Sensors, 2022
Many algorithms use 3D accelerometer and/or gyroscope data from inertial measurement unit (IMU) sensors to detect gait events (i.e., initial and final foot contact).
Robbin Romijnders, Elke Warmerdam, Clint Hansen, Gerhard Schmidt, Walter Maetzler   +4 more
doaj   +1 more source