The biology of fracture healing [PDF]
The biology of fracture healing is a complex biological process that follows specific regenerative patterns and involves changes in the expression of several thousand genes. Although there is still much to be learned to fully comprehend the pathways of bone regeneration, the over-all pathways of both the anatomical and biochemical events have been ...
Richard, Marsell, Thomas A, Einhorn
openaire +2 more sources
Many algorithms use 3D accelerometer and/or gyroscope data from inertial measurement unit (IMU) sensors to detect gait events (i.e., initial and final foot contact).
Robbin Romijnders +4 more
doaj +1 more source
Impact of Janus Kinase Inhibition with Tofacitinib on Fundamental Processes of Bone Healing [PDF]
Both inflammatory diseases like rheumatoid arthritis (RA) and anti-inflammatory treatment of RA with glucocorticoids (GCs) or non-steroidal anti-inflammatory drugs (NSAIDs) negatively influence bone metabolism and fracture healing.
Brinkman, Antonia Clara Katharina +10 more
core +1 more source
Single-Cell RNA Sequencing Reveals B Cells Are Important Regulators in Fracture Healing
The bone marrow microenvironment is composed primarily of immune and stromal cells that play important roles in fracture healing. Although immune cells have been identified in mouse bone marrow, variations in their numbers and type during the fracture ...
Hao Zhang +12 more
doaj +1 more source
VEGF with AMD3100 Endogenously Mobilizes Mesenchymal Stem Cells and Improves Fracture Healing [PDF]
A significant number of fractures develop non‐union. Mesenchymal stem cell (MSC) therapy may be beneficial, however, this requires cell acquisition, culture and delivery. Endogenous mobilization of stem cells offers a non‐invasive alternative.
Blunn, G +3 more
core +3 more sources
Dynamization of the plate in treating nonunion of the tibial fracture: Case report
Background: Plate osteosynthesis for the tibial fracture is one of the alternative treatments with satisfactory outcomes. Appropriate surgical techniques, including an open or minimally invasive approach, absolute or relative stability regarding fracture
Chittawee Jiamton +4 more
doaj +1 more source
Low Dose of Propranolol Does Not Affect Rat Osteotomy Healing and Callus Strength [PDF]
Experimental studies suggest that the β‐blocker propranolol stimulates bone formation but little work has investigated its effect on fracture healing. In this study, we examined if a low dose of propranolol, previously shown to be preventive against bone
Apel +39 more
core +2 more sources
Immunohistochemical localization of key arachidonic acid metabolism enzymes during fracture healing in mice. [PDF]
This study investigated the localization of critical enzymes involved in arachidonic acid metabolism during the initial and regenerative phases of mouse femur fracture healing.
Hsuan-Ni Lin, J Patrick O'Connor
doaj +1 more source
Research progress in the roles of Notch signaling pathway during fracture healing
Fracture is the most common large-organ injury in humans. It takes several months or even longer from the onset to the completion of bone reconstruction. In severe cases, delayed healing or even bone discontinuity can occur.
GUO Liqiang, ZHAO Shitian, SHU Bing
doaj +1 more source
Computer simulation of fatigue under diametrical compression [PDF]
We study the fatigue fracture of disordered materials by means of computer simulations of a discrete element model. We extend a two-dimensional fracture model to capture the microscopic mechanisms relevant for fatigue, and we simulate the diametric ...
Andrade Jr., J. S. +3 more
core +2 more sources

