Characterization of a reproducible model of fracture healing in mice using an open femoral osteotomy [PDF]
, 2020 Purpose: The classic fracture model, described by Bonnarens and Einhorn in 1984, enlists a blunt guillotine to generate a closed fracture in a pre-stabilized rodent femur.
Akkus, O. +6 more
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Accelerated Calvarial Healing in Mice Lacking Toll-Like Receptor 4 [PDF]
, 2012 The bone and immune systems are closely interconnected. The immediate inflammatory response after fracture is known to trigger a healing cascade which plays an important role in bone repair.
Adam A. Kubala +7 more
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Single-Cell RNA Sequencing Reveals B Cells Are Important Regulators in Fracture Healing
Frontiers in Endocrinology, 2021 The bone marrow microenvironment is composed primarily of immune and stromal cells that play important roles in fracture healing. Although immune cells have been identified in mouse bone marrow, variations in their numbers and type during the fracture ...
Hao Zhang +12 more
doaj +1 more source
Research progress in the roles of Notch signaling pathway during fracture healing
Shanghai Jiaotong Daxue xuebao. Yixue ban, 2023 Fracture is the most common large-organ injury in humans. It takes several months or even longer from the onset to the completion of bone reconstruction. In severe cases, delayed healing or even bone discontinuity can occur.
GUO Liqiang, ZHAO Shitian, SHU Bing
doaj +1 more source
Spatial Distribution of Macrophages During Callus Formation and Maturation Reveals Close Crosstalk Between Macrophages and Newly Forming Vessels [PDF]
, 2019 Macrophages are essential players in the process of fracture healing, acting by remodeling of the extracellular matrix and enabling vascularization. Whilst activated macrophages of M1-like phenotype are present in the initial pro-inflammatory phase of ...
Aulich, Linus +11 more
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Dynamization of the plate in treating nonunion of the tibial fracture: Case report
Journal of Orthopaedic Reports, 2023 Background: Plate osteosynthesis for the tibial fracture is one of the alternative treatments with satisfactory outcomes. Appropriate surgical techniques, including an open or minimally invasive approach, absolute or relative stability regarding fracture
Chittawee Jiamton +4 more
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Computer simulation of fatigue under diametrical compression [PDF]
, 2007 We study the fatigue fracture of disordered materials by means of computer simulations of a discrete element model. We extend a two-dimensional fracture model to capture the microscopic mechanisms relevant for fatigue, and we simulate the diametric ...
Andrade Jr., J. S. +3 more
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Bone Reports, 2021 Introduction: Osteoporosis is characterised by low bone mass and micro-architectural deterioration of bone structure. Its treatment is directed at the processes of bone formation or resorption, that are of utmost importance in fracture healing.
E.A. Gorter +4 more
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Fracture healing following high energy tibial trauma: Ilizarov versus Taylor Spatial Frame [PDF]
, 2014 Introduction: The optimal treatment of high energy tibial fractures remains controversial and a challenging orthopaedic problem. The role of external fi xators for all these tibial fractures has been shown to be crucial. Methods: A fi ve-year consecutive
AS Rigby +11 more
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Immunohistochemical localization of key arachidonic acid metabolism enzymes during fracture healing in mice. [PDF]
PLoS ONE, 2014 This study investigated the localization of critical enzymes involved in arachidonic acid metabolism during the initial and regenerative phases of mouse femur fracture healing.
Hsuan-Ni Lin, J Patrick O'Connor
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