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Impact of osteoporosis and osteoporosis medications on fracture healing: a narrative review
Osteoporosis InternationalAntiresorptive medications do not negatively affect fracture healing in humans. Teriparatide may decrease time to fracture healing. Romosozumab has not shown a beneficial effect on human fracture healing.
Manju Chandran +2 more
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Seminars in Musculoskeletal Radiology, 2022
Abstract Physiologic bone healing involves numerous parameters, such as microstability, fracture morphology, or tissue perfusion, to name just a few. Slight imbalances or a severe impairment of even one of these factors may, as the figurative weakest link in the chain, crucially or completely inhibit the regenerative potential of a ...
Paul Mick, Christian Fischer
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Abstract Physiologic bone healing involves numerous parameters, such as microstability, fracture morphology, or tissue perfusion, to name just a few. Slight imbalances or a severe impairment of even one of these factors may, as the figurative weakest link in the chain, crucially or completely inhibit the regenerative potential of a ...
Paul Mick, Christian Fischer
openaire +2 more sources
The Role of the Immune Cells in Fracture Healing
Current Osteoporosis Reports, 2018 Purpose of reviewBone fracture healing is a complex physiological process relying on numerous cell types and signals. Inflammatory factors secreted by immune cells help to control recruitment, proliferation, differentiation, and activation of ...
Gurpreet Baht +2 more
exaly +2 more sources
Journal of the American Academy of Orthopaedic Surgeons, 2006
Acceleration of the fracture healing process would have far-reaching benefits for both civilians and military personnel. Decreasing the time to return to complete function would reduce medical costs, enhance quality of life by decreasing pain and increasing mobility, accelerate the return of professional athletes to their sport, and decrease the time ...
Puzas, J. Edward +2 more
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Acceleration of the fracture healing process would have far-reaching benefits for both civilians and military personnel. Decreasing the time to return to complete function would reduce medical costs, enhance quality of life by decreasing pain and increasing mobility, accelerate the return of professional athletes to their sport, and decrease the time ...
Puzas, J. Edward +2 more
openaire +2 more sources
THE BIOMECHANICS OF FRACTURE HEALING
The Journal of Bone & Joint Surgery, 1955THE BIOMECHANICS OF FRACTURE HEALING Mikio Yamagishi;Yoshiyuki Yoshimura; The Journal of Bone & Joint ...
M, YAMAGISHI, Y, YOSHIMURA
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Complications of fractures and their healing
Seminars in Nuclear Medicine, 1988The role of nuclear medicine studies in diagnosing late complications of fractures is described. Static bone scintigraphy is not helpful in predicting delayed or non-union of fractures. Several investigators have developed simple formulae comparing uptake in fracture site with adjacent or contralateral normal bone and described criteria that will ...
I R, McDougall, C A, Keeling
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Inhibition of fracture healing
The Journal of Bone and Joint Surgery. British volume, 2007This paper reviews the current literature concerning the main clinical factors which can impair the healing of fractures and makes recommendations on avoiding or minimising these in order to optimise the outcome for patients. The clinical implications are described.
M S, Gaston, A H R W, Simpson
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Effects of Aging on Fracture Healing
Current Osteoporosis Reports, 2017Purpose of ReviewThis review summarizes research on the physiological changes that occur with aging and the resulting effects on fracture healing.Recent FindingsAging affects the inflammatory response during fracture healing through senescence of the ...
Mary C Nakamura +2 more
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Acta Biomaterialia, 2019
Increasing evidence has suggested that paracrine mechanisms might be involved in the underlying mechanism of mesenchymal stem cells (MSCs) transplantation, and exosomes are an important component of this paracrine role.
Wei Liu +25 more
semanticscholar +1 more source
Increasing evidence has suggested that paracrine mechanisms might be involved in the underlying mechanism of mesenchymal stem cells (MSCs) transplantation, and exosomes are an important component of this paracrine role.
Wei Liu +25 more
semanticscholar +1 more source
Current Opinion in Rheumatology, 2013
Published data raise concerns about the use of nonselective NSAIDs and selective cyclo-oxygenase (COX)-2 inhibitors as anti-inflammatory or analgesic drugs in patients after a recent fracture or who are undergoing (uncemented) arthroplasty or osteotomy.
Geusens, P.P. +3 more
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Published data raise concerns about the use of nonselective NSAIDs and selective cyclo-oxygenase (COX)-2 inhibitors as anti-inflammatory or analgesic drugs in patients after a recent fracture or who are undergoing (uncemented) arthroplasty or osteotomy.
Geusens, P.P. +3 more
openaire +3 more sources