Results 21 to 30 of about 1,704,060 (353)

Simulation-based prediction of bone healing and treatment recommendations for lower leg fractures: Effects of motion, weight-bearing and fibular mechanics

Frontiers in Bioengineering and Biotechnology, 2023
Despite recent experimental and clinical progress in the treatment of tibial and fibular fractures, in clinical practice rates of delayed bone healing and non-union remain high.
Marcel Orth, Bergita Ganse, Bergita Ganse, Annchristin Andres, Kerstin Wickert, Elke Warmerdam, Max Müller, Stefan Diebels, Michael Roland, Tim Pohlemann   +9 more
doaj   +1 more source

A Deep Learning Approach for Gait Event Detection from a Single Shank-Worn IMU: Validation in Healthy and Neurological Cohorts

Sensors, 2022
Many algorithms use 3D accelerometer and/or gyroscope data from inertial measurement unit (IMU) sensors to detect gait events (i.e., initial and final foot contact).
Robbin Romijnders, Elke Warmerdam, Clint Hansen, Gerhard Schmidt, Walter Maetzler   +4 more
doaj   +1 more source

Exosomes from bone marrow mesenchymal stem cells enhance fracture healing through the promotion of osteogenesis and angiogenesis in a rat model of nonunion

Stem cell research & therapeutics, 2020
As important players in cell-to-cell communication, exosomes (exo) are believed to play a similar role in promoting fracture healing. This study investigated whether exosomes derived from bone marrow mesenchymal stem cells (BMMSC-Exos) could improve ...
Lu Zhang, Guangjun Jiao, Shanwu Ren, Xiaoqian Zhang, Ci Li, Wenliang Wu, Hongliang Wang, Haichun Liu, Hongming Zhou, Yunzhen Chen   +9 more
semanticscholar   +1 more source

Bone Healing and Inflammation: Principles of Fracture and Repair

Seminars in Plastic Surgery, 2021
Bones comprise a significant percentage of human weight and have important physiologic and structural roles. Bone remodeling occurs when healthy bone is renewed to maintain bone strength and maintain calcium and phosphate homeostasis. It proceeds through
Hassan Elhawary, A. Baradaran, Jad Abi-Rafeh, J. Vorstenbosch, Liqin Xu, J. Efanov   +5 more
semanticscholar   +1 more source

Age‐related changes to macrophages are detrimental to fracture healing in mice

Aging Cell, 2020
The elderly population suffers from higher rates of complications during fracture healing that result in increased morbidity and mortality. Inflammatory dysregulation is associated with increased age and is a contributing factor to the myriad of age ...
D. Clark, Sloane A. Brazina, Frank Yang, D. Hu, Christine L. Hsieh, E. Niemi, T. Miclau, Mary C. Nakamura, R. Marcucio   +8 more
semanticscholar   +1 more source

Heterogeneity of murine periosteum progenitors involved in fracture healing

bioRxiv, 2020
The periosteum is the major source of cells involved in fracture healing. We sought to characterize progenitor cells and their contribution to bone fracture healing. The periosteum is highly enriched for progenitor cells, including Sca1+ cells, CFU-F and
B. Matthews, S. Novak, F. Sbrana, Jessica L Funnell, Ye Cao, E. Buckels, D. Grčević, I. Kalajzic   +7 more
semanticscholar   +1 more source

Single-Cell RNA Sequencing Reveals B Cells Are Important Regulators in Fracture Healing

Frontiers in Endocrinology, 2021
The bone marrow microenvironment is composed primarily of immune and stromal cells that play important roles in fracture healing. Although immune cells have been identified in mouse bone marrow, variations in their numbers and type during the fracture ...
Hao Zhang, Renkai Wang, Renkai Wang, Guangchao Wang, Bo Zhang, Chao Wang, Di Li, Chen Ding, Qiang Wei, Zhenyu Fan, Hao Tang, Fang Ji, Fang Ji   +12 more
doaj   +1 more source

Akkermansia muciniphila promotes type H vessel formation and bone fracture healing by reducing gut permeability and inflammation

Disease Models & Mechanisms, 2020
Improving revascularization is one of the major measures in fracture treatment. Moderate local inflammation triggers angiogenesis, whereas systemic inflammation hampers angiogenesis.
Jiang-Hua Liu, Tao Yue, Zhong-Wei Luo, Jia Cao, Zi-Qi Yan, Ling Jin, Teng‐Fei Wan, C. Shuai, Zhengguang Wang, Yong Zhou, Ran Xu, Hui Xie   +11 more
semanticscholar   +1 more source

Immunohistochemical localization of key arachidonic acid metabolism enzymes during fracture healing in mice. [PDF]

PLoS ONE, 2014
This study investigated the localization of critical enzymes involved in arachidonic acid metabolism during the initial and regenerative phases of mouse femur fracture healing.
Hsuan-Ni Lin, J Patrick O'Connor
doaj   +1 more source

Research progress in the roles of Notch signaling pathway during fracture healing

Shanghai Jiaotong Daxue xuebao. Yixue ban, 2023
Fracture is the most common large-organ injury in humans. It takes several months or even longer from the onset to the completion of bone reconstruction. In severe cases, delayed healing or even bone discontinuity can occur.
GUO Liqiang, ZHAO Shitian, SHU Bing
doaj   +1 more source