Effects of Aging on Fracture Healing [PDF]
Current Osteoporosis Reports, 2017 This review summarizes research on the physiological changes that occur with aging and the resulting effects on fracture healing.Aging affects the inflammatory response during fracture healing through senescence of the immune response and increased systemic pro-inflammatory status.
D. Clark +3 more
semanticscholar +5 more sources
Dysfunctional stem and progenitor cells impair fracture healing with age [PDF]
, 2019 Successful fracture healing requires the simultaneous regeneration of both the bone and vasculature; mesenchymal stem cells (MSCs) are directed to replace the bone tissue, while endothelial progenitor cells (EPCs) form the new vasculature that supplies ...
Clauss, Matthias +12 more
core +1 more source
VEGF with AMD3100 Endogenously Mobilizes Mesenchymal Stem Cells and Improves Fracture Healing [PDF]
, 2018 A significant number of fractures develop non‐union. Mesenchymal stem cell (MSC) therapy may be beneficial, however, this requires cell acquisition, culture and delivery. Endogenous mobilization of stem cells offers a non‐invasive alternative.
Blunn, G +3 more
core +3 more sources
Self-healing (solitonic) slip pulses in frictional systems [PDF]
Physical Review E 107, L013001 (2023), 2022 A prominent spatiotemporal failure mode of frictional systems is self-healing slip pulses, which are propagating solitonic structures that feature a characteristic length. Here, we numerically derive a family of steady state slip pulse solutions along generic and realistic rate-and-state dependent frictional interfaces, separating large deformable ...
arxiv +1 more source
Earthquake Breakdown Energy Scaling Despite Constant Fracture Energy [PDF]
Nat Commun 13, 1005 (2022), 2021 In the quest to determine fault weakening processes that govern earthquake mechanics, it is common to infer the earthquake breakdown energy from seismological measurements. Breakdown energy is observed to scale with slip, which is often attributed to enhanced fault weakening with continued slip or at high slip rates, possibly caused by flash heating ...
arxiv +1 more source
Gait Analysis to Monitor Fracture Healing of the Lower Leg [PDF]
, 2023 Fracture healing is typically monitored by infrequent radiographs. Radiographs come at the cost of radiation exposure and reflect fracture healing with a time lag due to delayed fracture mineralization following increases in stiffness.
Ganse, Bergita +3 more
core +1 more source
Maze Solving Automatons for Self-Healing of Open Interconnects: Modular Add-on for Circuit Boards [PDF]
Appl. Phys. Lett. 106, 123103 (2016), 2014 We present the circuit board integration of a self-healing mechanism to repair open faults. The electric field driven mechanism physically restores fractured interconnects in electronic circuits and has the ability to solve mazes. The repair is performed by conductive particles dispersed in an insulating fluid.
arxiv +1 more source
Low Dose of Propranolol Does Not Affect Rat Osteotomy Healing and Callus Strength [PDF]
, 2014 Experimental studies suggest that the β‐blocker propranolol stimulates bone formation but little work has investigated its effect on fracture healing. In this study, we examined if a low dose of propranolol, previously shown to be preventive against bone
Apel +39 more
core +2 more sources
Characterization of a reproducible model of fracture healing in mice using an open femoral osteotomy [PDF]
, 2020 Purpose: The classic fracture model, described by Bonnarens and Einhorn in 1984, enlists a blunt guillotine to generate a closed fracture in a pre-stabilized rodent femur.
Akkus, O. +6 more
core +1 more source
Radiographic, Biomechanical and Histological Characterization of Femoral Fracture Healing in Aged CD-1 Mice [PDF]
, 2023 With a gradually increasing elderly population, the treatment of geriatric patients represents a major challenge for trauma and reconstructive surgery.
Ehnert, Sabrina +8 more
core +1 more source