Results 21 to 30 of about 91,875 (296)

Methods to accelerate fracture healing – a narrative review from a clinical perspective

Frontiers in Immunology
Bone regeneration is a complex pathophysiological process determined by molecular, cellular, and biomechanical factors, including immune cells and growth factors.
Bergita Ganse, Bergita Ganse
doaj   +1 more source

Muscle atrophy in polytraumatized patients – a longitudinal observational pilot study

Frontiers in Physiology
In polytraumatized patients, muscle atrophy appears more pronounced than in immobilized healthy study participants. However, rates and trajectories of the acute muscle atrophy and associated parameters have not been reported.
Danjana Teves, Torsten Pastor, Torsten Pastor, Tatjana Pastor, Bergita Ganse, Bergita Ganse, Bergita Ganse   +6 more
doaj   +1 more source

Biomechanical Characteristics of Osteoporotic Fracture Healing in Ovariectomized Rats: A Systematic Review.

PLoS ONE, 2016
Biomechanical tests are widely used in animal studies on osteoporotic fracture healing. However, the biomechanical recovery process is still unknown, leading to difficulty in choosing time points for biomechanical tests and in correctly assessing ...
Lin Chen, Long Yang, Min Yao, Xue-Jun Cui, Chun-Chun Xue, Yong-Jun Wang, Bing Shu   +6 more
doaj   +1 more source

NPY and CGRP Inhibitor Influence on ERK Pathway and Macrophage Aggregation during Fracture Healing

Cellular Physiology and Biochemistry, 2017
Aim: The aims of this study are to investigate the effects of neurotransmitters NPY and CGRP on ERK signaling in fracture healing, and to identify the correlation between macrophage aggregation and fracture healing. Methods: Male Sprague-Dawley rats were
Peng Tang, Chunguang Duan, Zheng Wang, ChunMei Wang, Guolin Meng, Kaifeng Lin, Qian Yang, Zhi Yuan   +7 more
doaj   +1 more source

Is sonic Hedgehog involved in human fracture healing? --a prospective study on local and systemic concentrations of SHH. [PDF]

PLoS ONE, 2014
INTRODUCTION: Sonic Hedgehog (SHH) is a new signalling pathway in bone repair. Evidence exist that SHH pathway plays a significant role in vasculogenesis and limb development during embryogenesis.
Stefan Eipeldauer, Anita Thomas, Leonard Hoechtl-Lee, Mathias Kecht, Harald Binder, Julia Koettstorfer, Markus Gregori, Kambiz Sarahrudi   +7 more
doaj   +1 more source

Intact Glucocorticoid Receptor Dimerization Is Deleterious in Trauma-Induced Impaired Fracture Healing

Frontiers in Immunology, 2021
Following severe trauma, fracture healing is impaired because of overwhelming systemic and local inflammation. Glucocorticoids (GCs), acting via the glucocorticoid receptor (GR), influence fracture healing by modulating the trauma-induced immune response.
Yasmine Hachemi, Anna E. Rapp, Sooyeon Lee, Ann-Kristin Dorn, Benjamin T. Krüger, Kathrin Kaiser, Anita Ignatius, Jan Tuckermann   +7 more
doaj   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Longitudinal weight and plantar pressure distribution while standing after tibial or malleolar fractures in patients with or without fracture union

Scientific Reports
Fracture healing is usually monitored by clinical impressions and radiographs. Objective and easy methods for assessing fracture healing without radiation would be beneficial. The aim of this study was to analyse whether weight and plantar pressure while
Elke Warmerdam, Sonja Baumgartner, Tim Pohlemann, Bergita Ganse   +3 more
doaj   +1 more source

New Parameters Based on Ground Reaction Forces for Monitoring Rehabilitation Following Tibial Fractures and Assessment of Heavily Altered Gait

Sensors
Instrumented insoles have created opportunities for patient monitoring via long-term recordings of ground reaction forces (GRFs). As the GRF curve is altered in patients after lower-extremity fracture, parameters defined on established curve landmarks ...
Christian Wolff, Elke Warmerdam, Tim Dahmen, Tim Pohlemann, Philipp Slusallek, Bergita Ganse   +5 more
doaj   +1 more source

Experimemtal Investigations Into the Healing of Fractures [PDF]

Acta Orthopaedica Scandinavica, 1950
(1950). Experimemtal Investigations Into the Healing of Fractures. Acta Orthopaedica Scandinavica: Vol. 19, No. 4, pp. 433-475.
Viggo Eskklund, Claus Munk Plum
openaire   +4 more sources