Results 51 to 60 of about 355,356 (281)

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Alloy design for fracture resistance [PDF]

Proceedings of the Indian Academy of Sciences Section C: Engineering Sciences, 1980
Several methods for improving the strength of metallic materials are available and correlations between strength and various microstructural features have been established. The purpose of this paper is to review parallel developments favouring improved fracture resistance. Resistance to fracture in monotonie loading, cyclic loading and when fracture is
Prasad, YVRK, Rao, Rama P
openaire   +3 more sources

Comparative evaluation of fracture resistance of incisor fragments using simple, bevel, internal groove preparation designs and reattached with nanocomposites: An in vitro study

Journal of Pharmacy and Bioallied Sciences, 2020
Aim: The aim of this in vitro study was to evaluate the fracture resistance of anterior crown fragments using three different preparation designs and reattached using two different nanocomposites.
Roshni Chandran, Sreeram Rayar, Arjun B Ravi, Kaushik Haridas   +3 more
doaj   +1 more source

Fracture Toughness of Silicate Glasses: Insights from Molecular Dynamics Simulations

, 2015
Understanding, predicting and eventually improving the resistance to fracture of silicate materials is of primary importance to design new glasses that would be tougher, while retaining their transparency. However, the atomic mechanism of the fracture in
Bauchy, Mathieu, Lee, Young Jea, Wang, Bu, Yu, Yingtian   +3 more
core   +2 more sources

Effects of stitching on delamination of satin weave carbon-epoxy laminates under mode I, mode II and mixed-mode I/II loadings [PDF]

, 2010
The objective of the present study is to characterize the effect of modified chain stitching on the delamination growth under mixed-mode I/II loading conditions.
AJ Kinloch, AP Mouritz, AP Mouritz, BV Sankar, D Liu, EM Wu, KL Rugg, Laurent Michel, LK Jain, LK Jain, LK Jain, LS Chen, M Grassi, MDK Wood, MDK Wood, ML Benzeggagh, ML Benzeggagh, P Davies, Renaud Othomene, SK Sharma, VA Guenon, Walid Trabelsi, X Sun   +22 more
core   +3 more sources

Adipokines and Associations With Incident Osteoporotic Fracture in Patients With Rheumatoid Arthritis

Arthritis Care &Research, EarlyView.
Objective We assessed whether circulating adipokines are associated with incident fractures in patients with rheumatoid arthritis (RA). Methods Three adipokines (adiponectin, leptin, and fibroblast growth factor [FGF]‐21) were measured using banked enrollment serum from participants in a longitudinal RA cohort.
Joshua F. Baker, Bryant R. England, Michael D. George, Hannah Brubeck, Brian Sauer, Aleksander Lenert, Punyasha Roul, Geoffrey M. Thiele, Ted R. Mikuls, Katherine D. Wysham   +9 more
wiley   +1 more source

Fracture Resistance and Patterns of Fracture in Maxillary Complete Dentures Reinforced with Glass and Aramid Fiber Mesh under Dynamic Fatigue Loading - An In Vitro Study

RGUHS Journal of Dental Sciences
Aim The aim of this study was to evaluate and compare the fracture resistance and patterns of fracture in unreinforced glass amp aramid fiber mesh reinforced maxillary complete dentures under dynamic fatigue loading.Methods Forty ...
Ancita Caroline Dsouza, Brijesh Shetty, Suhas Rao K   +2 more
doaj   +1 more source

Controlled intermittent interfacial bond concept for composite materials [PDF]

, 1975
Concept will enhance fracture resistance of high-strength filamentary composite without degrading its tensile strength or elastic modulus. Concept provides more economical composite systems, tailored for specific applications, and composite materials ...
Atkins, A. G., Marston, T. U.
core   +1 more source

Investigation on some factors affecting crack formation in high resistance aluminum alloys [PDF]

, 2017
Aluminum alloys having good mechanical properties are Al-Zn-Mg alloys (7xxx) and Al-Cu-Li alloys (Weldalite®). These alloys may be subjected to stress corrosion cracking.
Brotzu, A., Felli, F., Pilone, D.
core   +3 more sources

The temporal trends and short‐ and long‐term mortality of people with acute myocardial infarction and rheumatoid arthritis: a nationwide cohort study

Arthritis Care &Research, Accepted Article.
Aims We investigated whether a diagnosis of rheumatoid arthritis (RA) affects the quality of inpatient acute myocardial infarction (AMI) care and long‐term mortality post‐AMI. Methods We analysed data from 784,091 adults, 6,047 with a diagnosis of RA, from England and Wales hospitalised with AMI between 2005 and 2019 from the MINAP registry, linked ...
Megan Butler, Nicholas Weight, Muhammad Rashid, Rodrigo Bagur, Purvi Parwani, Samantha Hider, Edward Roddy, Robert Butler, Mamas A Mamas   +8 more
wiley   +1 more source