Fragile x mental retardation protein regulates proliferation and differentiation of adult neural stem/progenitor cells. [PDF]
PLoS Genetics, 2010 Fragile X syndrome (FXS), the most common form of inherited mental retardation, is caused by the loss of functional fragile X mental retardation protein (FMRP). FMRP is an RNA-binding protein that can regulate the translation of specific mRNAs.
Yuping Luo +13 more
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Neuroanatomy of fragile X syndrome is associated with aberrant behavior and the fragile X mental retardation protein (FMRP) [PDF]
Annals of Neurology, 2007 To determine how neuroanatomic variation in children and adolescents with fragile X syndrome is linked to reduced levels of the fragile X mental retardation-1 protein and to aberrant cognition and ...
Doron Gothelf +14 more
core +7 more sources
Role of microRNA Pathway in Mental Retardation [PDF]
The Scientific World Journal, 2007 Deficits in cognitive functions lead to mental retardation (MR). Understanding the genetic basis of inherited MR has provided insights into the pathogenesis of MR.
Abrar Qurashi, Shuang Chang, Peng Jin
doaj +3 more sources
Focal areas of a high rate of fragile X in Indonesia: a long term follow up [PDF]
Journal of Biomedicine and Translational Research, 2019 Fragile X syndrome (FXS) is the most common cause of inherited intellectual disability (ID) and a leading cause of autism spectrum disorder (ASD). FXS is caused by an expansion of CGG repeats >200 in the 5′ untranslated region of the promotor region ...
Sultana MH Faradz, Tri Indah Winarni
doaj +3 more sources
The fragile X mental retardation protein inhibits translation via interacting with mRNA [PDF]
Nucleic Acids Research, 2001 Fragile X syndrome is a frequent form of inherited mental retardation caused by functional loss of the fragile X mental retardation protein, FMRP. The function of FMRP is unknown, as is the mechanism by which its loss leads to cognitive deficits.
Z. Li
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Trapping of messenger RNA by Fragile X Mental Retardation protein into cytoplasmic granules induces translation repression [PDF]
Human Molecular Genetics, 2002 Absence of Fragile X Mental Retardation Protein (FMRP), an RNA-binding protein, is responsible for the Fragile X syndrome, the most common form of inherited mental retardation.
Rachid Mazrouï
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Kissing complex RNAs mediate interaction between the Fragile-X mental retardation protein KH2 domain and brain polyribosomes [PDF]
Genes & Development, 2005 Fragile-X mental retardation is caused by loss of function of a single gene encoding the Fragile-X mental retardation protein, FMRP, an RNA-binding protein that harbors two KH-type and one RGG-type RNA-binding domains.
Jennifer C. Darnell +6 more
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The bantam microRNA is associated with drosophila fragile X mental retardation protein and regulates the fate of germline stem cells. [PDF]
PLoS Genetics, 2009 Fragile X syndrome, a common form of inherited mental retardation, is caused by the loss of fragile X mental retardation protein (FMRP). We have previously demonstrated that dFmr1, the Drosophila ortholog of the fragile X mental retardation 1 gene, plays
Yingyue Yang +6 more
doaj +4 more sources
Alterations of Amino Acids and Monoamine Metabolism in Male Fmr1 Knockout Mice: A Putative Animal Model of the Human Fragile X Mental Retardation Syndrome [PDF]
Neural Plasticity, 2001 The Fragile X syndrome, a common form of mental retardation in humans, is caused by silencing the fragile X mental retardation (FMR1) geneleading to the absence of the encoded fragile X mental retardation protein 1 (FMRP).
Michael Gruss, Katharina Braun
doaj +4 more sources
Fragile X Mental Retardation Protein: Nucleocytoplasmic Shuttling and Association with Somatodendritic Ribosomes [PDF]
Journal of Neuroscience, 1997 Fragile X syndrome, a leading cause of inherited mental retardation, is attributable to the unstable expansion of a CGG-repeat within the FMR1 gene that results in the absence of the encoded protein.
Yue Feng +5 more
openalex +2 more sources