Results 131 to 140 of about 28,384 (213)

Aberrant differentiation of glutamatergic cells in neocortex of mouse model for fragile X syndrome

Neurobiology of Disease, 2009
The lack of fragile X mental retardation protein (FMRP) causes fragile X syndrome, a common form of inherited mental retardation. Our previous studies revealed alterations in the differentiation of FMRP-deficient neural progenitors.
Topi A. Tervonen, Verna Louhivuori, Xiaohong Sun, Marie-Estelle Hokkanen, Claudius F. Kratochwil, Pawel Zebryk, Eero Castrén, Maija L. Castrén   +7 more
doaj   +1 more source

Progress toward therapeutic potential for AFQ056 in Fragile X syndrome

Journal of Experimental Pharmacology, 2013
Mary Sourial, Connie Cheng, Laurie C Doering Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada Abstract: Fragile X syndrome (FXS) is the most common form of inherited intellectual disability and the leading ...
Sourial M, Cheng C, Doering LC
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Reduced Levels of the Synaptic Functional Regulator FMRP in Dentate Gyrus of the Aging Sprague-Dawley Rat

Frontiers in Aging Neuroscience, 2017
Fragile X mental retardation protein (FMRP) encoded by Fragile X mental retardation 1 (FMR1) gene is a RNA-binding regulator of mRNA translation, transport and stability with multiple targets responsible for proper synaptic function. Epigenetic silencing
Roman Smidak, Fernando J. Sialana, Martina Kristofova, Tamara Stojanovic, Dragana Rajcic, Jovana Malikovic, Daniel D. Feyissa, Volker Korz, Harald Hoeger, Judit Wackerlig, Diana Mechtcheriakova, Gert Lubec, Gert Lubec   +12 more
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Fragile X mental retardation protein in intrahepatic cholangiocarcinoma: regulating the cancer cell behavior plasticity at the leading edge. [PDF]

Oncogene, 2021
Carotti S, Zingariello M, Francesconi M, D'Andrea L, Latasa MU, Colyn L, Fernandez-Barrena MG, Flammia RS, Falchi M, Righi D, Pedini G, Pantano F, Bagni C, Perrone G, Rana RA, Avila MA, Morini S, Zalfa F.   +17 more
europepmc   +1 more source

Interactions of the Fragile X Protein Family with the G Quadruplex Forming RNA Targets [PDF]

, 2008
The absence of fragile X mental retardation protein (FMRP) causes Fragile X Syndrome, the most common form of inherited mental retardation. FMRP, an RNA binding protein and, part of large ribonucleoprotein complexes, is proposed to participate in the ...
Menon, Lakshmi
core   +1 more source

The Fragile X Mental Retardation Protein Regulates RIPK1 and Colorectal Cancer Resistance to Necroptosis. [PDF]

Cell Mol Gastroenterol Hepatol, 2021
Di Grazia A, Marafini I, Pedini G, Di Fusco D, Laudisi F, Dinallo V, Rosina E, Stolfi C, Franzè E, Sileri P, Sica G, Monteleone G, Bagni C, Monteleone I.   +13 more
europepmc   +1 more source

Fragile X Mental Retardation Protein Mediates the Effects of Androgen on Hippocampal PSD95 Expression and Dendritic Spines Density/Morphology and Autism-Like Behaviors Through miR-125a. [PDF]

Front Cell Neurosci, 2022
Chen H, Qiao D, Wang C, Zhang B, Wang Z, Tang L, Wang Y, Zhang R, Zhang Y, Song L, Zuo H, Guo F, Wang X, Li S, Cui H.   +14 more
europepmc   +1 more source

Gene therapy using an ortholog of human fragile X mental retardation protein partially rescues behavioral abnormalities and EEG activity. [PDF]

Mol Ther Methods Clin Dev, 2021
Hooper AWM, Wong H, Niibori Y, Abdoli R, Karumuthil-Melethil S, Qiao C, Danos O, Bruder JT, Hampson DR.   +8 more
europepmc   +1 more source

Increased expression of Fragile X mental retardation protein in malformative lesions of patients with focal cortical dysplasia. [PDF]

Neuroreport, 2020
Reynolds CD, Nolan SO, Smith GD, Jefferson TS, Hodges SL, Brewster AL, Lugo JN.   +6 more
europepmc   +1 more source

Progress in the study on pathogenic mechanism of fragile X mental retardation protein

Chinese Journal of Contemporary Neurology and Neurosurgery, 2010
DOI：10.3969/j.issn.1672-6731.2010.03 ...
Yu⁃xia DONG, Xiao⁃hong SUN, Wei⁃ke SONG, et al   +3 more
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