Results 11 to 20 of about 16,167 (234)

Multifarious Functions of the Fragile X Mental Retardation Protein. [PDF]

open access: yesTrends Genet, 2017
Fragile X syndrome (FXS), a heritable intellectual and autism spectrum disorder (ASD), results from the loss of Fragile X mental retardation protein (FMRP). This neurodevelopmental disease state exhibits neural circuit hyperconnectivity and hyperexcitability.
Davis JK, Broadie K.
europepmc   +6 more sources

Cellular distribution of the fragile X mental retardation protein in the mouse brain. [PDF]

open access: yesJ Comp Neurol, 2017
ABSTRACTThe fragile X mental retardation protein (FMRP) plays an important role in normal brain development. Absence of FMRP results in abnormal neuronal morphologies in a selected manner throughout the brain, leading to intellectual deficits and sensory dysfunction in the fragile X syndrome (FXS). Despite FMRP importance for proper brain function, its
Zorio DA   +4 more
europepmc   +5 more sources

Fragile X mental retardation protein expression in Alzheimer’s disease [PDF]

open access: yesFrontiers in Genetics, 2014
The FMR1 protein product, FMRP, is an mRNA binding protein associated with translational inhibition of target transcripts. One FMRP target is the amyloid precursor protein (APP) mRNA, and APP levels are elevated in Fmr1 KO mice. Given that elevated APP
Abigail J Renoux   +4 more
doaj   +4 more sources

Interregulation between fragile X mental retardation protein and methyl CpG binding protein 2 in the mouse posterior cerebral cortex. [PDF]

open access: yesHum Mol Genet, 2021
Several X-linked neurodevelopmental disorders including Rett syndrome, induced by mutations in the MECP2 gene, and fragile X syndrome (FXS), caused by mutations in the FMR1 gene, share autism-related features.
Arsenault J   +9 more
europepmc   +2 more sources

The Fragile X Mental Retardation Protein Regulates Striatal Medium Spiny Neuron Synapse Density and Dendritic Spine Morphology. [PDF]

open access: yesFront Mol Neurosci, 2020
The fragile X mental retardation protein (FMRP), an RNA-binding protein that mediates the transport, stability, and translation of hundreds of brain RNAs, is critically involved in regulating synaptic function. Loss of FMRP, as in fragile X syndrome (FXS)
Huebschman JL   +3 more
europepmc   +2 more sources

Fragile x mental retardation protein regulates proliferation and differentiation of adult neural stem/progenitor cells. [PDF]

open access: yesPLoS Genetics, 2010
Fragile X syndrome (FXS), the most common form of inherited mental retardation, is caused by the loss of functional fragile X mental retardation protein (FMRP). FMRP is an RNA-binding protein that can regulate the translation of specific mRNAs.
Yuping Luo   +13 more
doaj   +2 more sources

Loss of the fragile X mental retardation protein causes aberrant differentiation in human neural progenitor cells. [PDF]

open access: yesSci Rep, 2018
Fragile X syndrome (FXS) is caused by transcriptional silencing of the FMR1 gene during embryonic development with the consequent loss of the encoded fragile X mental retardation protein (FMRP).
Sunamura N   +4 more
europepmc   +2 more sources

HITS-CLIP in various brain areas reveals new targets and new modalities of RNA binding by fragile X mental retardation protein. [PDF]

open access: yesNucleic Acids Res, 2018
Fragile X syndrome (FXS), the most common form of inherited intellectual disability, is due to the functional deficiency of the fragile X mental retardation protein (FMRP), an RNA-binding protein involved in translational regulation of many messenger ...
Maurin T   +8 more
europepmc   +2 more sources

Fragile X Mental Retardation Protein: Nucleocytoplasmic Shuttling and Association with Somatodendritic Ribosomes [PDF]

open access: hybridJournal of Neuroscience, 1997
Fragile X syndrome, a leading cause of inherited mental retardation, is attributable to the unstable expansion of a CGG-repeat within the FMR1 gene that results in the absence of the encoded protein.
Yue Feng   +5 more
openalex   +2 more sources

Nuclear Fragile X Mental Retardation Protein is localized to Cajal bodies. [PDF]

open access: yesPLoS Genetics, 2013
Fragile X syndrome is caused by loss of function of a single gene encoding the Fragile X Mental Retardation Protein (FMRP). This RNA-binding protein, widely expressed in mammalian tissues, is particularly abundant in neurons and is a component of ...
Alain Y Dury   +6 more
doaj   +5 more sources

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