Results 11 to 20 of about 28,576 (267)

A novel function for fragile X mental retardation protein in translational activation. [PDF]

open access: yesPLoS Biology, 2009
Fragile X syndrome, the most frequent form of inherited mental retardation, is due to the absence of Fragile X Mental Retardation Protein (FMRP), an RNA-binding protein involved in several steps of RNA metabolism.
Elias G Bechara   +10 more
doaj   +17 more sources

Neuroanatomy of fragile X syndrome is associated with aberrant behavior and the fragile X mental retardation protein (FMRP) [PDF]

open access: greenAnnals of Neurology, 2007
To determine how neuroanatomic variation in children and adolescents with fragile X syndrome is linked to reduced levels of the fragile X mental retardation-1 protein and to aberrant cognition and ...
Doron Gothelf   +14 more
core   +7 more sources

Multifarious Functions of the Fragile X Mental Retardation Protein. [PDF]

open access: yesTrends Genet, 2017
Fragile X syndrome (FXS), a heritable intellectual and autism spectrum disorder (ASD), results from the loss of Fragile X mental retardation protein (FMRP). This neurodevelopmental disease state exhibits neural circuit hyperconnectivity and hyperexcitability.
Davis JK, Broadie K.
europepmc   +6 more sources

Cellular distribution of the fragile X mental retardation protein in the mouse brain. [PDF]

open access: yesJ Comp Neurol, 2017
ABSTRACTThe fragile X mental retardation protein (FMRP) plays an important role in normal brain development. Absence of FMRP results in abnormal neuronal morphologies in a selected manner throughout the brain, leading to intellectual deficits and sensory dysfunction in the fragile X syndrome (FXS). Despite FMRP importance for proper brain function, its
Zorio DA   +4 more
europepmc   +5 more sources

Kissing complex RNAs mediate interaction between the Fragile-X mental retardation protein KH2 domain and brain polyribosomes. [PDF]

open access: goldGenes & Development, 2005
Fragile-X mental retardation is caused by loss of function of a single gene encoding the Fragile-X mental retardation protein, FMRP, an RNA-binding protein that harbors two KH-type and one RGG-type RNA-binding domains.
J. Darnell   +6 more
semanticscholar   +2 more sources

Fragile X mental retardation protein modulates the stability of its m6A-marked messenger RNA targets. [PDF]

open access: yesHum Mol Genet, 2018
&NA; N 6‐methyladenosine (m6A) is the most prevalent internal modification of mammalian messenger RNAs (mRNAs) and long non‐coding RNAs. The biological functions of this reversible RNA modification can be interpreted by cytoplasmic and nuclear ‘m6A ...
Zhang F   +9 more
europepmc   +2 more sources

Fragile X mental retardation protein expression in Alzheimer’s disease [PDF]

open access: yesFrontiers in Genetics, 2014
The FMR1 protein product, FMRP, is an mRNA binding protein associated with translational inhibition of target transcripts. One FMRP target is the amyloid precursor protein (APP) mRNA, and APP levels are elevated in Fmr1 KO mice. Given that elevated APP
Abigail J Renoux   +4 more
doaj   +4 more sources

Fragile X Mental Retardation Protein Bidirectionally Controls Dendritic Ih in a Cell Type-Specific Manner between Mouse Hippocampus and Prefrontal Cortex. [PDF]

open access: yesJ Neurosci, 2020
Channelopathies are implicated in Fragile X syndrome (FXS), yet the dysfunction of a particular ion channel varies with cell type. We previously showed that HCN channel function is elevated in CA1 dendrites of the fmr1–/y mouse model of FXS, but reduced ...
Brandalise F   +6 more
europepmc   +2 more sources

The bantam microRNA is associated with drosophila fragile X mental retardation protein and regulates the fate of germline stem cells. [PDF]

open access: yesPLoS Genetics, 2009
Fragile X syndrome, a common form of inherited mental retardation, is caused by the loss of fragile X mental retardation protein (FMRP). We have previously demonstrated that dFmr1, the Drosophila ortholog of the fragile X mental retardation 1 gene, plays
Yingyue Yang   +6 more
doaj   +4 more sources

The Human Fragile X Mental Retardation Protein Inhibits the Elongation Step of Translation through Its RGG and C-Terminal Domains. [PDF]

open access: yesBiochemistry, 2020
Fragile X mental retardation protein (FMRP) is an RNA-binding protein that regulates the translation of numerous mRNAs in neurons. The precise mechanism of translational regulation by FMRP is unknown.
Athar YM, Joseph S.
europepmc   +2 more sources

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