Results 11 to 20 of about 28,384 (213)

Nuclear Fragile X Mental Retardation Protein is localized to Cajal bodies. [PDF]

PLoS Genetics, 2013
Fragile X syndrome is caused by loss of function of a single gene encoding the Fragile X Mental Retardation Protein (FMRP). This RNA-binding protein, widely expressed in mammalian tissues, is particularly abundant in neurons and is a component of ...
Alain Y Dury, Rachid El Fatimy, Sandra Tremblay, Timothy M Rose, Jocelyn Côté, Paul De Koninck, Edouard W Khandjian   +6 more
doaj   +4 more sources

Fragile X mental retardation protein controls ion channel expression and activity [PDF]

The Journal of Physiology, 2016
Fragile X-associated disorders are a family of genetic conditions resulting from the partial or complete loss of fragile X mental retardation protein (FMRP).
Ferron, L
core   +5 more sources

Fragile X mental retardation protein regulates trans-synaptic signaling in Drosophila [PDF]

Disease Models & Mechanisms, 2013
SUMMARY Fragile X syndrome (FXS), the most common inherited determinant of intellectual disability and autism spectrum disorders, is caused by loss of the fragile X mental retardation 1 (FMR1) gene product (FMRP), an mRNA-binding translational repressor.
Samuel H. Friedman, Neil Dani, Emma Rushton, Kendal Broadie   +3 more
doaj   +3 more sources

A novel function for fragile X mental retardation protein in translational activation. [PDF]

PLoS Biology, 2009
Fragile X syndrome, the most frequent form of inherited mental retardation, is due to the absence of Fragile X Mental Retardation Protein (FMRP), an RNA-binding protein involved in several steps of RNA metabolism.
Elias G Bechara, Marie Cecile Didiot, Mireille Melko, Laetitia Davidovic, Mounia Bensaid, Patrick Martin, Marie Castets, Philippe Pognonec, Edouard W Khandjian, Hervé Moine, Barbara Bardoni   +10 more
doaj   +5 more sources

Role of fragile X mental retardation protein in chronic pain. [PDF]

Mol Pain, 2020
Chronic pain has detrimental effects on one’s quality of life. However, its treatment options are very limited, and its underlying pathogenesis remains unclear. Recent research has suggested that fragile X mental retardation protein is involved in the development of chronic pain, making it a potential target for prevention and treatment.
Mei X, Yang Y, Zhao J, Wang Y, Chen Q, Qian X, Li X, Feng Z.   +7 more
europepmc   +4 more sources

Fragile X mental retardation protein: from autism to neurodegenerative disease [PDF]

Frontiers in Cellular Neuroscience, 2015
Fragile X mental retardation protein (FMRP) is a RNA binding protein, the absence of which due to silencing of the FMR1 gene causes fragile X syndrome, an X-linked neurodevelopmental disorder (Bassell and Warren, 2008; Bhakar et al., 2012; Santoro et al., 2012). FMRP regulates the transport, stability and translation of its mRNA targets.
Hansen eWang
doaj   +3 more sources

Differential regulation of BK channels by fragile X mental retardation protein. [PDF]

J Gen Physiol, 2020
Fragile X mental retardation protein (FMRP) is an RNA-binding protein prominently expressed in neurons. Missense mutations or complete loss of FMRP can potentially lead to fragile X syndrome, a common form of inherited intellectual disability. In addition to RNA regulation, FMRP was also proposed to modulate neuronal function by direct interaction with
Kshatri A, Cerrada A, Gimeno R, Bartolomé-Martín D, Rojas P, Giraldez T.   +5 more
europepmc   +3 more sources

RNA-Binding Specificity of the Human Fragile X Mental Retardation Protein. [PDF]

J Mol Biol, 2020
Fragile X syndrome is the most common form of inherited intellectual disability and is caused by a deficiency of the fragile X mental retardation protein (FMRP) in neurons. FMRP regulates the translation of numerous mRNAs within dendritic synapses, but how FMRP recognizes these target mRNAs remains unknown.
Athar YM, Joseph S.
europepmc   +6 more sources

Multifarious Functions of the Fragile X Mental Retardation Protein. [PDF]

Trends Genet, 2017
Fragile X syndrome (FXS), a heritable intellectual and autism spectrum disorder (ASD), results from the loss of Fragile X mental retardation protein (FMRP). This neurodevelopmental disease state exhibits neural circuit hyperconnectivity and hyperexcitability.
Davis JK, Broadie K.
europepmc   +4 more sources

Fragile X Mental Retardation Protein and the Ribosome [PDF]

Molecular Cell, 2014
In this issue of Molecular Cell, Chen et al. (2014) provide evidence that FMRP represses translation by binding the ribosome, suggesting a novel form of translational control.
Harigaya, Yuriko, Parker, Roy
openaire   +2 more sources