Fragile X Mental Retardation Protein and Cerebral Expression of Metabotropic Glutamate Receptor Subtype 5 in Men with Fragile X Syndrome: A Pilot Study. [PDF]
Brain Sci, 2022 Multiple lines of evidence suggest that a deficiency of Fragile X Mental Retardation Protein (FMRP) mediates dysfunction of the metabotropic glutamate receptor subtype 5 ...
Brašić JR +13 more
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Role of fragile X mental retardation protein in chronic pain. [PDF]
Mol Pain, 2020 Chronic pain has detrimental effects on one’s quality of life. However, its treatment options are very limited, and its underlying pathogenesis remains unclear. Recent research has suggested that fragile X mental retardation protein is involved in the development of chronic pain, making it a potential target for prevention and treatment.
Mei X +7 more
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Muscle Specific Fragile X Related Protein 1 Isoforms are Sequestered in the Nucleus of Undifferentiated Myoblast [PDF]
BMC Genetics, 2000 Background The family of Fragile X Mental Retardation Proteins is composed of three members: Fragile Mental Retardation 1, Fragile X Related 1 and X Related 2 proteins.
Khandjian Edouard W +2 more
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Fragile X Mental Retardation Protein: To Be or Not to Be a Translational Enhancer. [PDF]
Front Mol Biosci, 2018 Maurin T, Bardoni B.
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Differential regulation of BK channels by fragile X mental retardation protein. [PDF]
J Gen Physiol, 2020 Fragile X mental retardation protein (FMRP) is an RNA-binding protein prominently expressed in neurons. Missense mutations or complete loss of FMRP can potentially lead to fragile X syndrome, a common form of inherited intellectual disability. In addition to RNA regulation, FMRP was also proposed to modulate neuronal function by direct interaction with
Kshatri A +5 more
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Fragile X mental retardation protein: from autism to neurodegenerative disease [PDF]
Frontiers in Cellular Neuroscience, 2015 Fragile X mental retardation protein (FMRP) is a RNA binding protein, the absence of which due to silencing of the FMR1 gene causes fragile X syndrome, an X-linked neurodevelopmental disorder (Bassell and Warren, 2008; Bhakar et al., 2012; Santoro et al., 2012). FMRP regulates the transport, stability and translation of its mRNA targets.
Hansen eWang
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The role of fragile X mental retardation protein in major mental disorders [PDF]
Neuropharmacology, 2010 Fragile X mental retardation protein (FMRP) is highly enriched in neurons and binds to approximately 4% of mRNAs in mammalian brain. Its loss is a hallmark of fragile X syndrome (FXS), the most common form of mental retardation. In this review we discuss the mutation in the fragile X mental retardation-1 gene (FMR1), that leads to FXS, the role FMRP ...
S. Hossein Fatemi, Timothy D. Folsom
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RNA-Binding Specificity of the Human Fragile X Mental Retardation Protein. [PDF]
J Mol Biol, 2020 Fragile X syndrome is the most common form of inherited intellectual disability and is caused by a deficiency of the fragile X mental retardation protein (FMRP) in neurons. FMRP regulates the translation of numerous mRNAs within dendritic synapses, but how FMRP recognizes these target mRNAs remains unknown.
Athar YM, Joseph S.
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Multifarious Functions of the Fragile X Mental Retardation Protein. [PDF]
Trends Genet, 2017 Fragile X syndrome (FXS), a heritable intellectual and autism spectrum disorder (ASD), results from the loss of Fragile X mental retardation protein (FMRP). This neurodevelopmental disease state exhibits neural circuit hyperconnectivity and hyperexcitability.
Davis JK, Broadie K.
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Fragile X mental retardation: Misregulation of protein synthesis in the developing brain? [PDF]
Microscopy Research and Technique, 2002 AbstractFragile X mental retardation results from the absence of a selective RNA‐binding protein, FMRP. Previous studies demonstrated that FMRP forms messenger ribonucleoprotein (mRNP) complexes to associate with translating polyribosomes, suggesting that FMRP is involved in regulating protein synthesis.
Yue Feng
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