Nuclear Fragile X Mental Retardation Protein is localized to Cajal bodies. [PDF]
PLoS Genetics, 2013 Fragile X syndrome is caused by loss of function of a single gene encoding the Fragile X Mental Retardation Protein (FMRP). This RNA-binding protein, widely expressed in mammalian tissues, is particularly abundant in neurons and is a component of ...
Alain Y Dury +6 more
doaj +5 more sources
RNA-Binding Specificity of the Human Fragile X Mental Retardation Protein [PDF]
Journal of Molecular Biology, 2020 Fragile X syndrome is the most common form of inherited intellectual disability and is caused by a deficiency of the fragile X mental retardation protein (FMRP) in neurons. FMRP regulates the translation of numerous mRNAs within dendritic synapses, but how FMRP recognizes these target mRNAs remains unknown.
Athar, Youssi M, Joseph, Simpson
openaire +6 more sources
The RNA binding protein fragile X mental retardation protein promotes myelin sheath growth [PDF]
Glia, 2020 During development, oligodendrocytes in the central nervous system extend a multitude of processes that wrap axons with myelin. The highly polarized oligodendrocytes generate myelin sheaths on many different axons, which are far removed from the cell ...
Caleb A. Doll, Katie M Yergert, B. Appel
semanticscholar +2 more sources
Fragile X mental retardation protein controls ion channel expression and activity [PDF]
Journal of Physiology, 2016 Fragile X-associated disorders are a family of genetic conditions resulting from the partial or complete loss of fragile X mental retardation protein (FMRP).
Ferron, L
core +2 more sources
Fragile X Mental Retardation Protein Targets G Quartet mRNAs Important for Neuronal Function [PDF]
Cell, 2001 Jennifer C. Darnell +5 more
openalex +2 more sources
Fragile X mental retardation protein modulates the stability of its m6A‐marked messenger RNA targets [PDF]
Hum Mol Genet, 2018 &NA; N 6‐methyladenosine (m6A) is the most prevalent internal modification of mammalian messenger RNAs (mRNAs) and long non‐coding RNAs. The biological functions of this reversible RNA modification can be interpreted by cytoplasmic and nuclear ‘m6A ...
Feiran Zhang +9 more
semanticscholar +2 more sources
Fragile X Mental Retardation Protein Bidirectionally Controls Dendritic Ih in a Cell Type-Specific Manner between Mouse Hippocampus and Prefrontal Cortex [PDF]
J Neurosci, 2020 Channelopathies are implicated in Fragile X syndrome (FXS), yet the dysfunction of a particular ion channel varies with cell type. We previously showed that HCN channel function is elevated in CA1 dendrites of the fmr1–/y mouse model of FXS, but reduced ...
Federico Brandalise +6 more
semanticscholar +2 more sources
The Human Fragile X Mental Retardation Protein Inhibits the Elongation Step of Translation through its RGG and C-terminal domains [PDF]
Biochemistry, 2020 Fragile X mental retardation protein (FMRP) is an RNA-binding protein that regulates the translation of numerous mRNAs in neurons. The precise mechanism of translational regulation by FMRP is unknown.
Y. Athar, S. Joseph
semanticscholar +2 more sources
The Fragile X Mental Retardation Protein Regulates Striatal Medium Spiny Neuron Synapse Density and Dendritic Spine Morphology [PDF]
Front Mol Neurosci, 2020 The fragile X mental retardation protein (FMRP), an RNA-binding protein that mediates the transport, stability, and translation of hundreds of brain RNAs, is critically involved in regulating synaptic function. Loss of FMRP, as in fragile X syndrome (FXS)
Jessica L. Huebschman +3 more
semanticscholar +2 more sources
Loss of the fragile X mental retardation protein causes aberrant differentiation in human neural progenitor cells [PDF]
Sci Rep, 2018 Fragile X syndrome (FXS) is caused by transcriptional silencing of the FMR1 gene during embryonic development with the consequent loss of the encoded fragile X mental retardation protein (FMRP).
Naohiro Sunamura +4 more
semanticscholar +2 more sources