Results 51 to 60 of about 172,523 (297)

Fragile X Mental Retardation Protein Regulates Activity-Dependent Membrane Trafficking and Trans-Synaptic Signaling Mediating Synaptic Remodeling [PDF]

Front Mol Neurosci, 2018
Fragile X syndrome (FXS) is the leading monogenic cause of autism and intellectual disability. The disease arises through loss of fragile X mental retardation protein (FMRP), which normally exhibits peak expression levels in early-use critical periods ...
James C. Sears, K. Broadie
semanticscholar   +2 more sources

The role of fragile X mental retardation protein in major mental disorders [PDF]

Neuropharmacology, 2010
Fragile X mental retardation protein (FMRP) is highly enriched in neurons and binds to approximately 4% of mRNAs in mammalian brain. Its loss is a hallmark of fragile X syndrome (FXS), the most common form of mental retardation. In this review we discuss the mutation in the fragile X mental retardation-1 gene (FMR1), that leads to FXS, the role FMRP ...
S. Hossein Fatemi, Timothy D. Folsom
openalex   +4 more sources

The Fragile X Mental Retardation Protein Regulates RIPK1 and Colorectal Cancer Resistance to Necroptosis [PDF]

Cell Mol Gastroenterol Hepatol, 2020
A. Di Grazia, I. Marafini, G. Pedini, D. Di Fusco, F. Laudisi, V. Dinallo, Eleonora Rosina, C. Stolfi, E. Franzè, P. Sileri, G. Sica, G. Monteleone, C. Bagni, I. Monteleone   +13 more
semanticscholar   +2 more sources

Fragile X mental retardation: Misregulation of protein synthesis in the developing brain? [PDF]

Microscopy Research and Technique, 2002
AbstractFragile X mental retardation results from the absence of a selective RNA‐binding protein, FMRP. Previous studies demonstrated that FMRP forms messenger ribonucleoprotein (mRNP) complexes to associate with translating polyribosomes, suggesting that FMRP is involved in regulating protein synthesis.
Yue Feng
openalex   +4 more sources

An “Omic” Overview of Fragile X Syndrome

Biology, 2021
Fragile X syndrome (FXS) is a neurodevelopmental disorder associated with a wide range of cognitive, behavioral and medical problems. It arises from the silencing of the fragile X mental retardation 1 (FMR1) gene and, consequently, in the absence of its ...
Olivier Dionne, François Corbin
doaj   +1 more source

Fragile X Mental Retardation Protein and the Ribosome [PDF]

Molecular Cell, 2014
In this issue of Molecular Cell, Chen et al. (2014) provide evidence that FMRP represses translation by binding the ribosome, suggesting a novel form of translational control.
Yuriko Harigaya, Yuriko Harigaya, Roy Parker, Roy Parker   +3 more
openaire   +3 more sources

On BC1 RNA and the fragile X mental retardation protein [PDF]

Proceedings of the National Academy of Sciences, 2008
The fragile X mental retardation protein (FMRP), the functional absence of which causes fragile X syndrome, is an RNA-binding protein that has been implicated in the regulation of local protein synthesis at the synapse. The mechanism of FMRP's interaction with its target mRNAs, however, has remained controversial. In one model, it has been
Anna Iacoangeli, Barthélémy Tournier, Edouard W. Khandjian, Natalia Dolzhanskaya, Janin Schütt, Jürgen Brosius, Stefan Kindler, Timofey S. Rozhdestvensky, Robert B. Denman, Henri Tiedge   +9 more
openaire   +8 more sources

Fragile X Mental Retardation Syndrome: Structure of the KH1-KH2 Domains of Fragile X Mental Retardation Protein [PDF]

Structure, 2007
Fragile X syndrome is the most common form of inherited mental retardation in humans, with an estimated prevalence of about 1 in 4000 males. Although several observations indicate that the absence of functional Fragile X Mental Retardation Protein (FMRP) is the underlying basis of Fragile X syndrome, the structure and function of FMRP are currently ...
Irina Pozdnyakova, Roberto Valverde, Lynne Regan, Janani Venkatraman, Tommi Kajander   +4 more
openaire   +3 more sources

Cytoplasmic Polyadenylation Element-Binding Protein 1 Post-transcriptionally Regulates Fragile X Mental Retardation 1 Expression Through 3′ Untranslated Region in Central Nervous System Neurons

Frontiers in Cellular Neuroscience, 2022
Fragile X syndrome (FXS) is an inherited intellectual disability caused by a deficiency in Fragile X mental retardation 1 (Fmr1) gene expression. Recent studies have proposed the importance of cytoplasmic polyadenylation element-binding protein 1 (CPEB1)
Souichi Oe, Shinichi Hayashi, Susumu Tanaka, Taro Koike, Yukie Hirahara, Ryohei Seki-Omura, Rio Kakizaki, Sumika Sakamoto, Yosuke Nakano, Yasuko Noda, Hisao Yamada, Masaaki Kitada   +11 more
doaj   +1 more source

Fragile X mental retardation protein and synaptic plasticity [PDF]

Molecular Brain, 2013
Abstract Loss of the translational repressor FMRP causes Fragile X syndrome. In healthy neurons, FMRP modulates the local translation of numerous synaptic proteins. Synthesis of these proteins is required for the maintenance and regulation of long-lasting changes in synaptic strength.
Sidorov, Michael Samuel, Auerbach, Benjamin David, Bear, Mark   +2 more
openaire   +4 more sources