Results 61 to 70 of about 8,261 (127)

When R‐Loops Go Awry: Genome Instability and Neurological Diseases

European Journal of Neuroscience, Volume 63, Issue 8, April 2026.
DNA normally exists as a double helix formed by two complementary strands. During gene transcription, however, one strand of DNA can bind to RNA, causing the other DNA strand to be displaced. This creates a structure called an R‐loop. R‐loops play important roles in normal cellular processes such as gene expression, DNA replication, and transcription ...
Nur Rasyiqin Rasli, Yu Katsuyama
wiley   +1 more source

Behavioral Phenotype Associations With Resting State EEG Signal Complexity and Power Spectral Density in Fragile X Syndrome

Autism Research, Volume 19, Issue 3, March 2026.
ABSTRACT Fragile X Syndrome (FXS), an X‐linked genetic condition, is associated with a wide range of phenotypic manifestations, namely intellectual disability (ID), autism spectrum disorder (ASD), attention deficit hyperactivity disorder (ADHD), and atypical behaviors.
Mélodie Proteau‐Lemieux, Inga S. Knoth, Saeideh Davoudi, Rae Buckser, Charles‐Olivier Martin, Anne‐Marie Bélanger, Valérie K. Fontaine, Hazel Maridith Barlahan Biag, Leonard Abbeduto, Sébastien Jacquemont, David Hessl, Randi J. Hagerman, Andrea Schneider, François V. Bolduc, Sarah Lippé   +14 more
wiley   +1 more source

IGF2BPs directly regulate the noncanonical translation of toxic proteins from mutant FMR1 mRNA containing expanded CGG repeats

Nature Communications
Mutant mRNA of the fragile X messenger ribonucleoprotein 1 gene (FMR1) containing expanded CGG repeats in its 5’UTR is a primary cause of fragile X premutation associated conditions.
Anna Baud, Damini Saha, Tomasz Skrzypczak, Izabela Broniarek, Daria Niewiadomska, Wojciech J. Szlachcic, Malgorzata Borowiak, Rajani Kanth Gudipati, Krzysztof Sobczak   +8 more
doaj   +1 more source

Fragile X Messenger Ribonucleoprotein 1 (FMR1), a novel inhibitor of osteoblast/osteocyte differentiation, regulates bone formation, mass, and strength in young and aged male and female mice.

, 2022
Lilian I. Plotkin, Padmini Deosthale, Julián Balanta‐Melo, Amy Creecy, Chongshan Liu, Alejandro Marcial, Laura Morales, Julita Cridlin, Sylvia Robertson, Chiebuka Okpara, David Sánchez, Madhi Ayoubi, Joaquín N. Lugo, Christopher J. Hernandez, Joseph M. Wallace   +14 more
openalex   +1 more source

A rapid and dynamic role for FMRP in the plasticity of adult neurons

Nature Communications
Fragile X syndrome is a neurodevelopmental disorder caused by silencing Fragile X messenger ribonucleoprotein 1 (Fmr1), which encodes the FMRP RNA-binding protein.
Daniel G. Gundermann, Seana Lymer, Jennifer Lennon, Justin Blau   +3 more
doaj   +1 more source

Dysfunctional neural dynamics associated with sensory phenotypes in Fragile X syndrome: insights from mouse models

Journal of Neurodevelopmental Disorders
Fragile X Syndrome (FXS), the leading known inherited cause of atypical behaviors associated with autism spectrum disorders (ASD), arises due to the reduced expression or absence of the Fragile X Messenger Ribonucleoprotein 1 (FMRP). Individuals with ASD
Anubhuti Goel, Khaleel A. Razak, Alexander A. Chubykin, Michelle W. Antoine   +3 more
doaj   +1 more source

Abnormal neural sensitivity to rewards as a candidate process of high depression risk in the FMR1 premutation: A pilot study

Journal of Mood and Anxiety Disorders
The etiological heterogeneity of depression poses a challenge for prevention and intervention efforts. One solution is to map unique etiological pathways for subgroups defined by a singular risk factor.
Roslyn Harold, Bridgette Kelleher, Keisha Novak, Wei Siong Neo, Teagan Stump, Taylor Lee, Tessa Garwood, Elizabeth Berry-Kravis, Dan Foti   +8 more
doaj   +1 more source

Plenary Abstracts Session & Oral Presentations

HemaSphere, Volume 10, Issue S1, June 2026.
wiley   +1 more source

Poster Sessions

HemaSphere, Volume 10, Issue S1, June 2026.
wiley   +1 more source

Publication Only

HemaSphere, Volume 10, Issue S1, June 2026.
wiley   +1 more source