Results 161 to 170 of about 125,088 (254)

CRISPR in MOF Formulation with Enhanced Stability, Activity, and Altered PAM Specificity for Broad‐Spectrum Diagnosis of Bacterial Sepsis

Advanced Science, Volume 13, Issue 8, 9 February 2026.
CRISPR‐FLEXMO (CRISPR with flexible PAM in MOF encapsulation) integrates a PAM‐relaxed Cas12a K607R enzyme with a manganese‐coordinated MOF for broad‐spectrum diagnosis of bacterial sepsis. The MOF enhances activity and preserves functionality under heat, solvent, and chaotropic stress, supporting long‐term room‐temperature storage.
Tathagata Pal, Zilong Liu, Meera G. Nair, Juhong Chen   +3 more
wiley   +1 more source

The Emerging Role of Phosphodiesterase Inhibitors in Fragile X Syndrome and Autism Spectrum Disorder. [PDF]

Pharmaceuticals (Basel)
Thomas SD, Mohammed HA, Hamad MIK, Oz M, Statsenko Y, Sadek B.   +5 more
europepmc   +1 more source

To Mars through LEO: How commercial space travel will change exploration‐enabling research

Experimental Physiology, EarlyView.
Christopher Puhl, Michail Magkos
wiley   +1 more source

Esketamine/Ketamine: Dual‐Action Mechanisms and Clinical Prospects beyond Anesthesia in Psychiatry, Immunology, and Oncology

Advanced Science, Volume 13, Issue 7, 3 February 2026.
Esketamine and ketamine are widely used for perioperative analgesia and anesthesia. Despite their established roles in analgesia, sedation, and anesthesia, as well as emerging antidepressant, anti‐tumor, and anti‐inflammatory effects, their clinical use is limited due to side effects and addiction potential.
Yinxin Wang, Jiangang Xu, Xinyu Zhou, Lu Che, Minghan Qiu, Yang Liu, Ming Gao, Zhen Yang   +7 more
wiley   +1 more source

Impaired hippocampal representation of place in the Fmr1-knockout mouse model of fragile X syndrome [PDF]

, 2018
Tara Arbab, Cyriel M. A. Pennartz, Francesco P. Battaglia   +2 more
openalex   +1 more source

Dysfunctional neural dynamics associated with sensory phenotypes in Fragile X syndrome: insights from mouse models. [PDF]

J Neurodev Disord
Goel A, Razak KA, Chubykin AA, Antoine MW.   +3 more
europepmc   +1 more source

De Novo Heterozygous ZFX Frameshift Variant in a Female With an X‐Linked Neurodevelopmental Disorder

American Journal of Medical Genetics Part A, Volume 200, Issue 2, Page 521-530, February 2026.
ABSTRACT Germline ZFX variants are associated with an X‐linked neurodevelopmental disorder, with 14 males and 16 females reported to date. We describe a 20‐year‐old female with a heterozygous ZFX frameshift variant, p.(Met666Valfs*2), identified by genome sequencing, previously reported in an affected male.
Iftekhar A. Showpnil, Allison Daley, Emily R. Sites, Shayne M. Plourde, Jesse M. Hunter, Dennis W. Bartholomew, April N. Lehman, Daniel C. Koboldt, Rolf W. Stottmann   +8 more
wiley   +1 more source

Genetic Screening Of Fragile X Syndrome -A Hospital Based Study [PDF]

KETHA KEREN BEULAH SAMUEL, Sunil Kumar Polipalli, Dinesh Kumar, SHEENA PRIYA BANDELA, HANCY UJWALA THADI   +4 more
openalex   +1 more source

Microbiome modulation and behavioural improvements in children with fragile X syndrome following probiotic intake: A pilot study. [PDF]

Sci Rep
Protic D, Bascarevic D, Dimitrijevic S, Pesovic J, Nikolic V, Nikolic S, Novicevic V, Markovic J, Arandjelovic I, Savic-Pavicevic D, Diricks M, Belheouane M, Merker M.   +12 more
europepmc   +1 more source

Neurogenesis and the Epigenetic Landscape: Role of Histone Modifications and Chromatin Remodeling

Brain and Behavior, Volume 16, Issue 2, February 2026.
Histone methylation and acetylation modulate gene expression by inducing chromatin condensation or relaxation, which in turn regulates transcriptional activity and impacts neurogenesis. ABSTRACT Aims The purpose of this review is to examine how epigenetic regulation particularly chromatin modification and histone methylation controls gene expression ...
Degisew Yinur Mengistu, Biniam Moges Eskeziyaw   +1 more
wiley   +1 more source