Results 141 to 150 of about 40,130 (258)

GABAergic neurons exhibit subtype-specific changes in the developing somatosensory cortex of a rat model of Fragile X Syndrome. [PDF]

Front Neurosci
Sumera A, Crichton A, Kind PC, Sibley C, Booker SA.   +4 more
europepmc   +1 more source

Lessons from clinical and genetic characterization of intellectual disability

Developmental Medicine &Child Neurology, EarlyView.
Fuki Marie Hisama
wiley   +1 more source

PDE4 Inhibition in Dermatologic Disease: Impacts Beyond Inflammation

International Journal of Dermatology, EarlyView.
This graphical abstract demonstrates the comprehensive mechanism of PDE4 inhibition in skin physiology. By increasing intracellular cAMP and activating PKA, PDE4 inhibitors exert pleiotropic effects, including immune modulation, pigmentation regulation, barrier enhancement, sensory neuron modulation, and improved wound healing with reduced fibrosis ...
Keana Khodadad, Nicole E. Chin, Raj Chovatiya   +2 more
wiley   +1 more source

Caregiver-perceived behavioral challenges in fragile X syndrome and implications for measuring treatment benefit in clinical trials. [PDF]

J Patient Rep Outcomes
Merikle E, Tich N, Sebree T, Hagerman R, O'Quinn S, Nomikos G, Bzdek K.   +6 more
europepmc   +1 more source

AI‐Enabled Automated Schistocyte Classification in Peripheral Blood for TMA Auxiliary Diagnosis

International Journal of Laboratory Hematology, EarlyView.
ABSTRACT Background Schistocytes are critical morphological markers for thrombotic microangiopathy (TMA) diagnosis. Manual identification is hampered by inconsistent standards and high interobserver variability, compromising accuracy. Although AI has advanced in hematology, AI‐enabled schistocyte classification remains under‐studied, creating a ...
Lei Shang, Chao Fang, Dongshuo Li, Xuesong Wang, Jiani Yu, Yunchu Cui, Jingliang Chen, Xuekai Liu   +7 more
wiley   +1 more source

Altered ECM deposition and cell adhesion signaling in a human cortical organoid model of fragile X syndrome. [PDF]

Mol Brain
Havusha-Laufer S, Krishnaswamy VR, Krugliak-Shechter N, Shenoy A, Karlinski Zur M, Kuznitsov-Yanovsky L, Solomonov I, Hanna JH, Sagi I, Ben Yosef D.   +9 more
europepmc   +1 more source

Wearable Electronic Monitoring of Vital Signs in Hospitalised Adults: A Nursing Focused Scoping Review of Clinical, Economic and Implementation Outcomes

Journal of Advanced Nursing, EarlyView.
ABSTRACT Aim To synthesise evidence on wearable devices for continuous vital signs monitoring in adult hospital inpatients, focusing on clinical effectiveness, nursing perspectives, workflow impact, patient experience and resource implications. Design Scoping review.
Sian Myfanwy Shaw, Sophie Bethan Shaw, Gillian Janes   +2 more
wiley   +1 more source

Contribution of astrocytic calcium signaling to auditory hypersensitivity in a mouse model of fragile X syndrome. [PDF]

Neurobiol Dis
Bergdolt L, Anding A, Alshaqi O, Arbabi Z, Douchey M, Eldridge E, Hoffman K, Reid A, Sapkota K, Monaghan D, Taraschenko O, Padmashri R, Dunaevsky A.   +12 more
europepmc   +1 more source

Effectiveness and Cost‐Effectiveness of Models of Healthcare for People With Intellectual Disability in Australia: A Scoping Review

Journal of Intellectual Disability Research, EarlyView.
ABSTRACT Background People with intellectual disability experience significant gaps in healthcare delivery resulting in poor health outcomes. Appropriately designed healthcare is required to meet the needs of this population and achieve better health outcomes.
Jenny Downs, Dragana Prodanovic, Ruth Leong, Katie Brooker, Helen Leonard, Julian N. Trollor, Kitty‐Rose Foley   +6 more
wiley   +1 more source

Planning for the Transition to Adulthood: Parent Perspectives on the Planning Process and Experiences of Young Adults with Fragile X Syndrome. [PDF]

Adv Neurodev Disord
Abbeduto L, Klusek J, Taylor JL, Thurman AJ.   +3 more
europepmc   +1 more source