Results 271 to 280 of about 225,713 (333)

Effects of the STriatal Enriched Tyrosine Phosphatase (STEP) Inhibitor TC‐2153 on Hippocampal Long‐Term Depression and Synaptic Transmission: Paradoxical Effect on Phosphatase Activity and Role of Adenosine

CNS Neuroscience &Therapeutics, Volume 32, Issue 3, March 2026.
In hippocampal slices, treatment with TC‐2153 for 1–2 h blocks the two forms of long‐term depression, mGlu‐LTD and NMDA‐LTD, by inhibiting the STriatal Enriched tyrosine Phosphatase (STEP). On the contrary, short‐term TC‐2153 application (10–20 min) increases STEP activity through a mechanism involving adenosine release and adenosine A1 receptor ...
Valentina Chiodi, Rita Pepponi, Lucia Gaddini, Zaira Boussadia, Emilia Marchei, Manuela Pellegrini, Cinzia Mallozzi, Maria Rosaria Domenici   +7 more
wiley   +1 more source

Clinical Significance of Fragile X Syndrome 2 (FXR2) in Breast Cancer. [PDF]

Genes (Basel)
Alsalmi OA, Aljohani AI, Almutairi SM, Alsufyani RO, Alrubayee AR, Alzahrani KJ, Alkhammash GE, Aljuaid HM, Alghamdi HS, Alsaeedi FA.   +9 more
europepmc   +1 more source

Fetal Pain Perception: Legislative Assertions and Developmental Neuroscience

Annals of the Child Neurology Society, Volume 4, Issue 1, Page 15-28, March 2026.
ABSTRACT Background Pain perception is a conscious experience, but neither pain nor consciousness is defined in the developing human fetus. Emergent consciousness may be regarded as a phenomenon that ultimately arises from an essential minimum of functional neuronal connectivity. Proposed U.S.
William D. Graf, Timothy M. Crombleholme, Leon G. Epstein, Dawn Gano, Phillip L. Pearl, Timothy V. Salomons, Mark S. Scher, Elise Turk, Klaus‐Peter Zimmer, Harvey B. Sarnat   +9 more
wiley   +1 more source

Beyond a Conduit: The Evolution of Functional Biliary Stents From Active Intervention to Enabling Platforms

iNew Medicine, Volume 2, Issue 1, March 2026.
This review traces the evolution of functional biliary stents, outlining the paradigm shift from “active intervention” strategies that target stent failure to next‐generation “enabling platforms.” These platforms leverage biodegradable materials, 3D/4D printing, and smart sensors to achieve personalized, regenerative, and theranostic solutions ...
Muhan Li, Xu Liu, Xin Ye, Zhixia Dong, Xinjian Wan   +4 more
wiley   +1 more source

Spontaneous Distal Ureteric Rupture in a Young Patient With Fragile X Syndrome. [PDF]

Cureus
Safdar H, Sardar M, Shaukat F, Sarwar Abbasi A, Tunio M.   +4 more
europepmc   +1 more source

Flow Cytometry Role in Unlocking New Frontiers for Nanomedicine Applications of Plant‐Derived Vesicles

Journal of Extracellular Biology, Volume 5, Issue 3, March 2026.
ABSTRACT Extracellular vesicles (EVs) are nanoscale membrane‐bound vesicles released by any cell type under both physiological and pathological conditions. They carry a wide array of bioactive molecules, including microRNAs (miRNAs), lipids, proteins and other small biomolecules, and therefore play a key role in intercellular communication by ...
Tamer Esmail, Sabino Porro, Francesca D'Ascanio, Domenico De Bellis, Arianna Aquilini‐Mummolo, Giulia Colasante, Pasquale Simeone, Ayesha Younas, Marwa Balaha, Mariagiulia Filoso, Luana D'Onofrio, Melania Dovizio, Eleonora Aruffo, Piero Di Carlo, Lorenzo Secondi, Federica Flamminii, Tiziana Pietrangelo, Chiara Porro, Patrizia Ballerini, Angelo Cichelli, Paola Lanuti   +20 more
wiley   +1 more source

Prevalence of Fragile X syndrome in Georgian patients with autism spectrum disorder and/or intellectual disability: cross-sectional study and review of current approaches. [PDF]

Front Pediatr
Tabatadze N, Koniashvili O, Melikishvili G, Bienvenu T, Cuisset L, Tassone F, Protic DD, Naneishvili N, Zarandia M, Gverdtsiteli S, Kakabadze S, Gachechiladze T, Melikishvili M, Kuchukashvili Z, Giunashvili T, Silagava K, Mamardashvili G, Chipashvili M, Barabadze K, Abbeduto L, Hagerman RJ.   +20 more
europepmc   +1 more source

Gastric Microbiome Alterations in Sepsis‐Related Gastrointestinal Bleeding: Two Case Reports and Literature Review

JGH Open, Volume 10, Issue 3, March 2026.
ABSTRACT Sepsis, characterized by life‐threatening organ dysfunction resulting from an uncontrolled response to infection, can impact various systems of the body, including the digestive system. Prior research has identified sepsis as a significant risk factor for gastrointestinal bleeding.
Fangjie Fu, Chen Zhang, Zhengying Xu, Peng Ji, Zhongwei Zhang   +4 more
wiley   +1 more source

Cognitive and Social-Emotional Development in Girls With Fragile X Syndrome. [PDF]

Pediatrics
Bartholomay KL, Lightbody AA, Ma Q, Jo B, Jordan TL, Reiss AL.   +5 more
europepmc   +1 more source