Results 31 to 40 of about 205,015 (256)
FEBS Letters, EarlyView.Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure +3 more
wiley +1 more source
Per un umanesimo della fragilità. La fragilità come virtù politica [PDF]
Democrazia e Diritti Sociali, 2023 How did we come to lose fragility as a constitutive value in the formation of the human being, reducing it to little less than a character defect to be treated?
Carmela Bianco
doaj
Extending displacement-based earthquake loss assessment (DBELA) for the computation of fragility curves [PDF]
, 2012 This paper presents a new procedure to derive fragility functions for populations of buildings that relies on the displacement-based earthquake loss assessment (DBELA) methodology.
SILVA MOURA PINHO, RUI JORGE +7 more
core +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
CCL5 Induces a Sarcopenic-like Phenotype via the CCR5 Receptor
AntioxidantsSarcopenia corresponds to a decrease in muscle mass and strength. CCL5 is a new myokine whose expression, along with the CCR5 receptor, is increased in sarcopenic muscle.
Francisco Aguirre +14 more
doaj +1 more source
Fragility, conflict, and migration
, 2023 Fragility, Conflict, and Migration addresses challenges to livelihood, food, and climate security faced by some of the most vulnerable populations worldwide.
Kosec, Katrina; Laderach, Peter; and Ruckstuhl, Sandra +1 more
core
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Scientific ReportsSarcopenia secondary to chronic cholestatic liver disease (CCLD) is linked to activation of the ubiquitin-proteasome system (UPS) and autophagy-lysosome system (ALS), impaired mitochondrial dynamics, and diminished mTOR signaling. Resistance training (RT)
Claudio Cabello-Verrugio +12 more
doaj +1 more source
Fragilité, vulnérabilité et ressorts de santé des personnes âgées
Populations Vulnérables, 2017 À partir d’observations socio-ethnographiques à domicile, cet article explore les conditions d’application des notions de fragilité, vulnérabilité et atouts / ressorts de santé au repérage, au suivi et à la prévention de la perte d’autonomie des ...
Hervé Michel +4 more
doaj +1 more source