Results 41 to 50 of about 187,854 (309)

CCL5 Induces a Sarcopenic-like Phenotype via the CCR5 Receptor

Antioxidants
Sarcopenia corresponds to a decrease in muscle mass and strength. CCL5 is a new myokine whose expression, along with the CCR5 receptor, is increased in sarcopenic muscle.
Francisco Aguirre, Franco Tacchi, Mayalen Valero-Breton, Josué Orozco-Aguilar, Sabrina Conejeros-Lillo, Josefa Bonicioli, Renata Iturriaga-Jofré, Daniel Cabrera, Jorge A. Soto, Mauricio Castro-Sepúlveda, Marianny Portal-Rodríguez, Álvaro A. Elorza, Andrea Matamoros, Felipe Simon, Claudio Cabello-Verrugio   +14 more
doaj   +1 more source

Fragilité, vulnérabilité et ressorts de santé des personnes âgées

Populations Vulnérables, 2017
À partir d’observations socio-ethnographiques à domicile, cet article explore les conditions d’application des notions de fragilité, vulnérabilité et atouts / ressorts de santé au repérage, au suivi et à la prévention de la perte d’autonomie des ...
Hervé Michel, Raphaël Koster, Alexandre Duclos, François Béland, Jacques Duchêne   +4 more
doaj   +1 more source

Fragile science

mBio
ABSTRACT Science currently faces major external and internal threats. External threats include persistent anti-science attacks, the post-pandemic politicization of public health, and chronic underfunding. Internal threats include a proliferation of low-quality studies, an epidemic of retractions, and questions ...
Arturo Casadevall, Ferric C. Fang
openaire   +3 more sources

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Fragilidades materiales

Revue d'anthropologie des connaissances, 2023
This introductory article shows how the prism of fragility can be used as a way to conceptually and empirically further the research work that has foregrounded the material part of human societies by focusing on the agency of artifacts and the strength ...
Jérôme Denis, David Pontille
doaj   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Gel and glass transition in fragile colloidal clays

Condensed Matter Physics, 2019
Dynamic Light Scattering (DLS) measurements were performed on colloidal suspensions of Laponite® at different concentrations in the range C_w = (1.5÷3.0)%.
R. Angelini, G. Ruocco, B. Ruzicka
doaj   +1 more source

The role of Christianity in mending societal fragility and quelling violence in Liberia

Verbum et Ecclesia, 2017
This article has benefited from the research entitled The role of Christianity in post-war Liberia . It is a study that attempts to examine and investigate how Christian faith and spirituality can play a role in a campaign for social peace, justice ...
Eric Gbotoe, Selaelo T. Kgatla
doaj   +1 more source