Results 61 to 70 of about 155,276 (311)
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
« Faire connaissance avec la fragilité des choses »
Revue d'anthropologie des connaissancesThis text is a reflection on material fragilities, grounded in the discussion of two case studies, which look at the reclamation of red mud from bauxite mining in Gardanne and the management of sealed biological samples used in the production of DNA ...
Ashveen Peerbaye
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Seismic Fragility Curves of RC Buildings Subjected to Aging
GeoHazardsA large number of existing reinforced concrete (RC) buildings have surpassed their anticipated service life and show signs of degradation due to aging; this degradation is a function of the construction practices adopted in the past as well as ...
Spyridon Diamantopoulos +4 more
doaj +1 more source
European Journal for Philosophy of Science, 2022 Reflexivity is, roughly, when studying or theorising about a target itself influences that target. Fragility is, roughly, when causal or other relations are hard to predict, holding only intermittently or fleetingly. Which is more important, methodologically? By going systematically through cases that do and do not feature each of them, I conclude that
openaire +2 more sources
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Molecular Oncology, EarlyView.Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen +11 more
wiley +1 more source
Fragility Analysis of Masonry Structures Subjected to Random Sequential Ground Motions
BuildingsIn this study, a fragility analysis of masonry structures is conducted using a random sequential ground motion model. Initially, the relationship between a mainshock and its aftershocks is clarified based on the physical mechanism of “source-path-local ...
Jialiu Pan +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
"Measuring Macroprudential Risk: Financial Fragility Indexes" [PDF]
With the Great Recession and the regulatory reform that followed, the search for reliable means to capture systemic risk and to detect macrofinancial problems has become a central concern.
Éric Tymoigne
core