Results 61 to 70 of about 187,854 (309)
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Seismic Fragility Curves of RC Buildings Subjected to Aging
GeoHazardsA large number of existing reinforced concrete (RC) buildings have surpassed their anticipated service life and show signs of degradation due to aging; this degradation is a function of the construction practices adopted in the past as well as ...
Spyridon Diamantopoulos +4 more
doaj +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
The microbiome in human skin aging
FEBS Letters, EarlyView.Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana +3 more
wiley +1 more source
Fragility Analysis of Masonry Structures Subjected to Random Sequential Ground Motions
BuildingsIn this study, a fragility analysis of masonry structures is conducted using a random sequential ground motion model. Initially, the relationship between a mainshock and its aftershocks is clarified based on the physical mechanism of “source-path-local ...
Jialiu Pan +3 more
doaj +1 more source
"Measuring Macroprudential Risk: Financial Fragility Indexes" [PDF]
With the Great Recession and the regulatory reform that followed, the search for reliable means to capture systemic risk and to detect macrofinancial problems has become a central concern.
Éric Tymoigne
core
FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source
Fragility crossover mediated by covalent-like electronic interactions in metallic liquids
Materials FuturesFragility is one of the central concepts in glass and liquid sciences, as it characterizes the extent of deviation of viscosity from Arrhenius behavior and is linked to a range of glass properties.
Hui-Ru Zhang +9 more
doaj +1 more source
The Fragile Definition of State Fragility [PDF]
We investigates the link between fragility and economic development in sub-Saharan Africa over a yearly panel including 28 countries for the 1999-2004 period.
Graziella Bertocchi, Andrea Guerzoni
core
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source