Results 81 to 90 of about 205,015 (256)
إنسانيات, 2018 Medical emergencies are being imbued with an ambiguity in status and profession, a structural gap in their functionning, and a medical and organizational « bankruptcy ».The emergencies, which primary mission is only to providing care for the sick persons
Abdelkrim Haouari +1 more
doaj +1 more source
Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies
FEBS Open Bio, EarlyView.We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli +8 more
wiley +1 more source
Chemically Driven Nano‐Elastic Heterogeneities Control Fragility in Volcanic Melts
Advanced ScienceHere, the nanoscale structural drivers of the mechanical behavior of volcanic glasses are explored. The study spans a compositional series ranging from basalt to rhyolite, encompassing also technical glass‐forming melts.
Michele Cassetta +13 more
doaj +1 more source
Monitoring Banking Sector Fragility [PDF]
In the financial crisis literature, it is usually argued that, contrary to the case of currency crises, building a time series index to identify banking crisis episodes is highly difficult, particularly because of the lack of reliable data on banking ...
Aykut Kibritcioglu
core
Versatile vector tools for efficient protein screening across multiple expression systems
FEBS Open Bio, EarlyView.A unified vector toolkit enables rapid protein expression screening across E. coli, insect, and mammalian cells. A single primer pair amplifies the target gene, which is inserted into any vector via a standardized interface. This streamlined workflow eliminates repeated cloning steps, accelerating the identification of optimal expression conditions for
Zhimin Zhu +5 more
wiley +1 more source
VaccinesSomalia is one of 20 countries in the world with the highest numbers of zero-dose children. This study aims to identify who and where zero-dose and under-vaccinated children are and what the existing vaccine delivery strategies to reach zero-dose ...
Ahmed Said Bile +8 more
doaj +1 more source
Financial Fragility and Economic Fluctuations: Numerical Simulations and Policy Implications [PDF]
This paper proposes a simple prototype model that describes the complex dynamics of a sophisticated monetary economy. The interaction between the current and intertemporal financial constraints of economic units brings about irregular fluctuations at the
Alessandro Vercelli, Serena Sordi
core
Dundee Discussion Papers in Economics 185:Extracting leading indicators of bank fragility from market prices: Estonia focus [PDF]
, 2005 Banking reform has proved to be one of the most problematic elements of economic transition in central and eastern Europe. Therefore the paper considers the development of the Estonian banking sector and derives individual banks´ fragility scores during ...
Mannasoo, Kadri +2 more
core
Directed evolution of enzymes at the crossroads of tradition and innovation
FEBS Open Bio, EarlyView.An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova +2 more
wiley +1 more source
FEBS Open Bio, EarlyView.Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill +6 more
wiley +1 more source