Results 81 to 90 of about 155,276 (311)

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Big Data for the stratification of readmission risk after hospital discharge of older adults with complex conditions

International Journal of Integrated Care, 2019
Introduction and objective: The increase in life expectancy along with scientific advances have led to an increasing number of elderly patients with several chronic conditions, requiring frequent hospital admissions due to exacerbation of their chronic ...
Xue He, Neus Gual, Ricard Gavaldà, Marco Inzitari   +3 more
doaj   +1 more source

Circulating tumor cell viability during and after radiotherapy mirrors treatment response in cancer patients

Molecular Oncology, EarlyView.
Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy, Jana Löptien, Cornelia Coith, Afroditi Nanou, Katharina Hintelmann, Pinnschmidt Hans, Cordula Petersen, Klaus Pantel, Sabine Riethdorf, Kerstin Borgmann, Harriet Wikman   +10 more
wiley   +1 more source

A model of financial fragility [PDF]

This paper presents a dynamic, stochastic game-theoretic model of financial fragility. The model has two essential features. First, interrelated portfolios and payment commitments forge financial linkages among agents.
Stacey L. Schreft, Roger D. Lagunoff
core  

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Rethinking food crisis responses: The Nigeria presentation of IFPRI's 2023 Global Food Policy Report & the launch of the CGIAR Research Initiative on Fragility, Conflict & Migration (FCM)

, 2023
The purpose of this report is to describe work presented and discussions resulting from an event jointly convened by the CGIAR Research Initiative on Fragility, Conflict, and Migration (FCM) and the International Food Policy Research Institute (IFPRI) in
https://orcid.org/0000-0001-9906-0107 Carrillo, Lucia; http://orcid.org/0000-0002-5126-5215 Kosec, Katrina; http://orcid.org/0000-0001-6035-1732 Smart, Jennifer; http://orcid.org/0000-0001-6277-0930 Ambler, Kate; http://orcid.org/0000-0002-4138-1693 Andam, K.; http://orcid.org/0000-0003-0560-3604 Edeh, Hyacinth O.; https://orcid.org/0000-0001-8259-7186 Fasoranti, Adetunji, Carrillo, Lucia; Kosec, Katrina; Onilogbo, Omobolanle; Smart, Jenny; Ambler, Kate; Andam, Kwaw S.; Anisimova, Evgeniya; Edeh, Hyacinth; Fasoranti, Adetunji; Mugisho, Aline   +1 more
core   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Dundee Discussion Papers in Economics 185:Extracting leading indicators of bank fragility from market prices: Estonia focus [PDF]

, 2005
Banking reform has proved to be one of the most problematic elements of economic transition in central and eastern Europe. Therefore the paper considers the development of the Estonian banking sector and derives individual banks´ fragility scores during ...
Mannasoo, Kadri, Chen, Yu-Fu, Funke, Michael   +2 more
core  

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Stock price fragility in an emerging market

, 2013
Includes bibliographical references.This research project examines stock price fragility, a measure developed by Greenwood and Thesmar (2011), which serves as a proxy for non-fundamental risk i.e.
Nairac, Jean-Michel
core