Results 71 to 80 of about 155,276 (311)

Fragility crossover mediated by covalent-like electronic interactions in metallic liquids

Materials Futures
Fragility is one of the central concepts in glass and liquid sciences, as it characterizes the extent of deviation of viscosity from Arrhenius behavior and is linked to a range of glass properties.
Hui-Ru Zhang, Liang Gao, Yu-Hao Ye, Jia-Xin Zhang, Tao Zhang, Qing-Zhou Bu, Qun Yang, Zeng-Wei Zhu, Shuai Wei, Hai-Bin Yu   +9 more
doaj   +1 more source

Fragile Pluralism

Entangled Religions, 2016
This essay first appeared in German in Magdalena Tzaneva, ed. Nachtflug der Eule: 150 Stimmen zum Werk von Niklas Luhmann. Gedenkbuch zum 15. Todestag von Niklas Luhmann (8. Dezember 1927 Lüneburg – 6. November 1998 Oerlinghausen). Berlin: LiDi EuropEdition (2013), 73–100. A shorter version of the essay was published in Hans-Georg Soeffner, and ...
openaire   +4 more sources

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

The Fragile Definition of State Fragility [PDF]

We investigates the link between fragility and economic development in sub-Saharan Africa over a yearly panel including 28 countries for the 1999-2004 period.
Graziella Bertocchi, Andrea Guerzoni
core  

Fragile Sustainability or Sustainable Fragility?

Svetovi: revija za etnologijo, antropologijo in folkloristiko
This article explores the materialisations of sustainability in the Logar Valley, an Alpine tourist destination in Slovenia. Drawing on ethnographic research, we examine how sustainability is understood and enacted by local tourism service providers, highlighting four key themes: food practices, the temporalities of tourism, transport, and ...
Ana Svetel, Veronika Zavratnik
openaire   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Capturing the Invisible

Svetovi
This article explores how digital devices shape aesthetic perceptions and interactions with fragile Finnish mires. Through senso-digital walking interviews, it examines how technologies like mobile cameras, social media, and navigation apps influence ...
Kirsi Laurén, Tiina Seppä, Juhana Venäläinen   +2 more
doaj   +1 more source

The Fragile Consensus on Fragility

, 2010
The concept of fragility, which was initially born in the security arena, has been gaining increasing relevance in the development discourse over the past few years. However, fragility still remains a fuzzy and elusive term. This paper identifies three main sets of definitions of fragility, which substantially differ in their focus and breadth.
BERTOLI, Simone, TICCI, Elisa
openaire   +1 more source