Results 121 to 130 of about 297,713 (300)
Comparative Studies in the Shoulder Literature Lack Statistical Robustness: A Fragility Analysis. [PDF]
Arthrosc Sports Med Rehabil, 2021 Parisien RL +8 more
europepmc +1 more source
FEBS Open Bio, EarlyView.This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia +3 more
wiley +1 more source
Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment
Aging and Cancer, EarlyView.Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey +12 more
wiley +1 more source
BuildingsMachine learning (ML) approaches, widely used in civil engineering, have the potential to reduce computing costs and enhance predictive capabilities. However, many ML methods have yet to be applied to develop models that accurately analyze the nonlinear ...
Yan Xu +4 more
doaj +1 more source
"The Financially Fragile Firm: Is There a Case for It in the 1920s?" [PDF]
This paper is an empirical investigation of Minsky's hypothesis in the U.S. consumer durables sector during the 1920s. The first section of the paper briefly describes Minsky's financial fragility hypothesis, while the second sketches a brief economic ...
D. L. Isenberg
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Aging Is a Key Driver for Adult Acute Myeloid Leukemia
Aging and Cancer, EarlyView.Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley +1 more source
Inappropriate use of proton-pump inhibitors and fragility fracture risk. A preliminary study [PDF]
, 2015 Introducción: Los inhibidores de la bomba de protones (IBP) son fármacos ampliamente utilizados, si bien esto conlleva a un sobreuso que no es acorde con las indicaciones aceptadas en España y en el resto de Europa.
Gómez de Tejada Romero, María Jesús
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Lessons Learned From a Delayed‐Start Trial of Modafinil for Freezing of Gait in Parkinson's Disease
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Freezing of gait (FOG) in people with Parkinson's disease (PwPD) is debilitating and has limited treatments. Modafinil modulates beta/gamma band activity in the pedunculopontine nucleus (PPN), like PPN deep brain stimulation. We therefore tested the hypothesis that Modafinil would improve FOG in PwPD.
Tuhin Virmani +8 more
wiley +1 more source
Yuanzineng kexue jishu, 2023 Seismic hazard analysis and seismic fragility analysis are import parts of seismic risk analysis of the nuclear power plant, and the site-specific spectra generation and selection of ground motion records are the key connecting steps between seismic ...
WANG Xiaolei;YAN Weidong;LYU Dagang
doaj
Impact of New Madrid Seismic Zone Earthquakes on the Central USA, Vol. 1 and 2 [PDF]
, 2009 The information presented in this report has been developed to support the Catastrophic Earthquake Planning Scenario workshops held by the Federal Emergency Management Agency.
Cleveland, Lisa J. +3 more
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