Results 51 to 60 of about 2,232,356 (345)

Probing equilibrium glass flow up to exapoise viscosities [PDF]

, 2015
Glasses are out-of-equilibrium systems aging under the crystallization threat. During ordinary glass formation, the atomic diffusion slows down rendering its experimental investigation impractically long, to the extent that a timescale divergence is ...
Cerullo, G., Ferrante, C., Pogna, E. A. A., Rodríguez-Tinoco, C., Rodríguez-Viejo, J., Scopigno, T.   +5 more
core   +2 more sources

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Probabilistic evaluation of seismic vulnerability of multi-span ‎bridges in north of Iran [PDF]

Journal of Structural and Construction Engineering, 2018
Bridges are known as the most susceptible components of any and transportation system. That is why before the earthquake in vulnerability assessment, to take the necessary actions.
Alireza Mirza Goltabar Roshan, Ali Naseri, Yaser Mahmoodi Pati   +2 more
doaj   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Density-temperature scaling of the fragility in a model glass-former

, 2013
Dynamical quantities such as the diffusion coefficient and relaxation times for some glass-formers may depend on density and temperature through a specific combination, rather than independently, allowing the representation of data over ranges of density
Sastry, Srikanth, Schröder, Thomas B., Sengupta, Shiladitya   +2 more
core   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Stochastic approach for analytical fragility curves

KSCE Journal of Civil Engineering, 2008
One of the main problems is the assessment of “residual reliability” or “vulnerability” of a single existing structure, or of a given class of similar structures, against seismic actions. The fragility curves describe the probability of a structure to suffer a given damage level when it is subject to a given seismic excitation level. This research work
MARANO, Giuseppe Carlo, GRECO, Rita, MEZZINA M.   +2 more
openaire   +3 more sources

Uncertainty and Quality rating in Analytical Vulnerability Assessment [PDF]

, 2014
Fragility curves represent a major component of seismic risk and vulnerability assessment of buildings and infrastructure facilities. A recently conducted extensive literature review under the framework of developing the “GEM Guide for Selecting of ...
D'Ayala, D, Ioannou, I, Lang, D, Meslem, A, Rossetto, T   +4 more
core  

Cross-comparative analysis of evacuation behavior after earthquakes using mobile phone data

, 2018
Despite the importance of predicting evacuation mobility dynamics after large scale disasters for effective first response and disaster relief, our general understanding of evacuation behavior remains limited because of the lack of empirical evidence on ...
Ikemoto, Satoshi, Sekimoto, Yoshihide, Tsubouchi, Kota, Yabe, Takahiro   +3 more
core   +2 more sources

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source