Results 71 to 80 of about 832,329 (300)
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source
Applied SciencesSeismic fragility curves, derived from ground motion data, are essential tools for predicting and assessing potential damage to structures during earthquakes.
Sangki Park +3 more
doaj +1 more source
Development of fragility curves for bridges in Korea
KSCE Journal of Civil Engineering, 2007 The purpose of this paper is to develop fragility curves for bridges in Korea. Fragility curves are needed for assessing the vulnerability of bridges to unscheduled events and for setting retrofit and/or repair priorities. Research results show that individual bridges suffer different levels of damage, depending not only on the magnitude of earthquake ...
Seongkwan Mark Lee +2 more
openaire +1 more source
, 2012 Colour photograph of the completed Curve which looms large next to the older buildings of the ...
Hyde, Colin;
core
Gut microbiota alterations in patients with non‐small‐cell lung cancer undergoing chemoradiotherapy
Molecular Oncology, EarlyView.We investigated the impact of concurrent chemoradiotherapy (CRT) on the gut microbiota in patients with locally advanced non‐small‐cell lung cancer. Overall gut microbiota composition remained largely stable throughout CRT while antibiotic exposure may influence microbial diversity.
Hanne Marte Nymoen +19 more
wiley +1 more source
, 2014 Colour photograph of the interior of the Curve Theatre, Leicester, showing lighting equipment in the stage ...
Barnes, Amy
core
Directed evolution of enzymes at the crossroads of tradition and innovation
FEBS Open Bio, EarlyView.An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova +2 more
wiley +1 more source
State fragility and economic vulnerability: what is measured and why? [PDF]
State fragility is a concept that emerged among the international community of donors in order to adapt aid policies to particularly difficult situations.
Sylviane GUILLAUMONT JEANNENEY +1 more
core +2 more sources