Results 61 to 70 of about 18,903 (299)

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

DEVELOPMENT OF FRAGILITY CURVES FOR REINFORCED DUNES

Coastal Engineering Proceedings, 2018
The objective of this paper is to present the results of on-going field studies to assess the performance of geotextile sand-filled container (GSC) reinforced dunes and to develop probabilistic fragility curves for a range of damage states to these structures.
Maggi, Brian, Baxter, Christopher, Bradshaw, Aaron, Grilli, Annette, Licht, Stephen, Stegagno, Paolo, Al Naser, Naser   +6 more
openaire   +1 more source

Circulating tumor cell viability during and after radiotherapy mirrors treatment response in cancer patients

Molecular Oncology, EarlyView.
Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy, Jana Löptien, Cornelia Coith, Afroditi Nanou, Katharina Hintelmann, Pinnschmidt Hans, Cordula Petersen, Klaus Pantel, Sabine Riethdorf, Kerstin Borgmann, Harriet Wikman   +10 more
wiley   +1 more source

Replication Data for: Tephra cushioning of ballistic impacts: Quantifying building vulnerability through pneumatic cannon experiments and multiple fragility curve fitting approaches

, 2021
Replication Data for: Tephra cushioning of ballistic impacts: Quantifying building vulnerability through pneumatic cannon experiments and multiple fragility curve fitting ...
Williams George Thomas
core   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Probabilistic seismic assessment of concrete frame with mass irregularity

Инженерно-строительный журнал, 2018
As mass irregular structures are more influencing on the behavior of the structures, it is investigated the effect of these irregularities according to the probabilistic approach.
Elahesadat Hashemi, Ali Kheyroddin, Mohsen Gerami   +2 more
doaj   +1 more source

IDA-Based Seismic Fragility Analysis of a Concrete-Filled Square Tubular Frame

Buildings
Based on the incremental dynamic analysis (IDA) method, this paper conducts seismic fragility analysis of a CFST plane frame, a CFST spatial frame under 1D (one-dimensional) ground motions, and a CFST spatial frame under 2D (two-dimensional) ground ...
Xiaoqiang Liu, Chengxiang Xu
doaj   +1 more source

Update of control parameters for semi‐actively controlled base‐isolated building to improve seismic performance

Japan Architectural Review, 2019
The Sosokan building of Keio University located in Yokohama, Japan, is a base‐isolated building with a semi‐active control system. The semi‐active dampers’ damping coefficient is changed to best reproduce the optimal control force in linear‐quadratic ...
Masayuki Kohiyama, Masashi Omura, Masaki Takahashi, Osamu Yoshida, Koichi Nakatsuka   +4 more
doaj   +1 more source

Seismic Vulnerability Assessment of a Shallow Two-Story Underground RC Box Structure

Applied Sciences, 2017
Tunnels, culverts, and subway stations are the main parts of an integrated infrastructure system. Most of them are constructed by the cut-and-cover method at shallow depths (mainly lower than 30 m) of soil deposits, where large-scale seismic ground ...
Jungwon Huh, Quang Huy Tran, Achintya Haldar, Innjoon Park, Jin-Hee Ahn   +4 more
doaj   +1 more source

Fragility Curves of Restoration Processes for Resilience Analysis [PDF]

, 2017
In literature the fragility curves are usually adopted to evaluate the probability of exceedance of a given damage state. This chapter presents for the first time a procedure for developing fragility curves of restoration processes which can be adopted for resilience analysis.
openaire   +2 more sources