Results 61 to 70 of about 832,329 (300)

Seismic Vulnerability Assessment of a Shallow Two-Story Underground RC Box Structure

Applied Sciences, 2017
Tunnels, culverts, and subway stations are the main parts of an integrated infrastructure system. Most of them are constructed by the cut-and-cover method at shallow depths (mainly lower than 30 m) of soil deposits, where large-scale seismic ground ...
Jungwon Huh, Quang Huy Tran, Achintya Haldar, Innjoon Park, Jin-Hee Ahn   +4 more
doaj   +1 more source

Invisible but not inaccessible—Revealing transient oligomers formed by intrinsically disordered proteins with solution NMR and complementary methods

FEBS Letters, EarlyView.
Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Soil-Structure Interaction Effect on Fragility Curve of 3D Models of Concrete Moment-Resisting Buildings

Shock and Vibration, 2018
This paper presents the probabilistic generation of collapse fragility curves for evaluating the performance of 3D, reinforced concrete (RC) moment-resisting building models, considering soil-structure interaction (SSI) by concentration on seismic ...
Ali Anvarsamarin, Fayaz Rahimzadeh Rofooei, Masoud Nekooei   +2 more
doaj   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

IDA-Based Seismic Fragility Analysis of a Concrete-Filled Square Tubular Frame

Buildings
Based on the incremental dynamic analysis (IDA) method, this paper conducts seismic fragility analysis of a CFST plane frame, a CFST spatial frame under 1D (one-dimensional) ground motions, and a CFST spatial frame under 2D (two-dimensional) ground ...
Xiaoqiang Liu, Chengxiang Xu
doaj   +1 more source

Update of control parameters for semi‐actively controlled base‐isolated building to improve seismic performance

Japan Architectural Review, 2019
The Sosokan building of Keio University located in Yokohama, Japan, is a base‐isolated building with a semi‐active control system. The semi‐active dampers’ damping coefficient is changed to best reproduce the optimal control force in linear‐quadratic ...
Masayuki Kohiyama, Masashi Omura, Masaki Takahashi, Osamu Yoshida, Koichi Nakatsuka   +4 more
doaj   +1 more source

Stochastic approach for analytical fragility curves

KSCE Journal of Civil Engineering, 2008
One of the main problems is the assessment of “residual reliability” or “vulnerability” of a single existing structure, or of a given class of similar structures, against seismic actions. The fragility curves describe the probability of a structure to suffer a given damage level when it is subject to a given seismic excitation level. This research work
MARANO, Giuseppe Carlo, GRECO, Rita, MEZZINA M.   +2 more
openaire   +3 more sources

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source