Results 81 to 90 of about 832,329 (300)

A Machine Learning Framework for Estimating Fragility Curves of Low- to Mid-Rise RC Buildings

Buildings
In performance-based earthquake engineering (PBEE), fragility curves hold significant importance for a reliable risk assessment of the existing reinforced concrete (RC) structures. Fragility curves require numerous incremental nonlinear dynamic analyses,
Ahmet Özdemir, Hakan Erdoğan, Hasan Özkaynak, Baki Öztürk, Safa Bozkurt Coşkun   +4 more
doaj   +1 more source

Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy

FEBS Open Bio, EarlyView.
This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan, Ikram A. Burney, Shika Hanif Malgundkar, Siva Ramamoorthy, Ressin Varghese, Mohamed A. Al‐Kindi, Hamad Al Riyami, Shadia Al Bahlani, Sergey Dobretsov, Syed Imran Hassan, Benjamin K. Tsang, Yahya Tamimi   +11 more
wiley   +1 more source

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

"Measuring Macroprudential Risk: Financial Fragility Indexes" [PDF]

With the Great Recession and the regulatory reform that followed, the search for reliable means to capture systemic risk and to detect macrofinancial problems has become a central concern.
Éric Tymoigne
core  

Assessing the impact of ground-motion variability and uncertainty on empirical fragility curves [PDF]

, 2015
Empirical fragility curves, constructed from databases of thousands of building-damage observations, are commonly used for earthquake risk assessments, particularly in Europe and Japan, where building stocks are often difficult to model analytically (e.g.
Rossetto, T, Douglas, J, Ioannou, I, Rossetto, Tiziana, Ioannou, Ioanna, Douglas, John   +5 more
core   +1 more source

MARK4 enhances stress granule formation under oxidative stress and increases tau accumulation

FEBS Open Bio, EarlyView.
MARK4 (red dots) localizes to stress granules (orange dots) and promotes their formation under oxidative stress by modulating TIA1 (blue dots). MARK4 and TIA1 synergistically increase tau (purple) accumulation, and the reduction of the TIA1 ortholog suppresses neurodegeneration in a fly model.
Sho Nakajima, Kotone Watanabe, Grigorii Sultanakhmetov, Aoi Fukuchi, Keiya Ito, Sawako Shimizu, Taro Saito, Akiko Asada, Kanae Ando   +8 more
wiley   +1 more source

Studi Kerentanan Bangunan Akibat Gempa : Studi Kasus Perumahan Di Bantul

Semesta Teknika, 2016
One of earthquake mitigation activities is to know the probability of damage to buildings and the estimated loss caused by the earthquake on each typical building in an area.
Adi Setiabudi Bawono
doaj  

Spectrum-consistent ag-based fragility curves.

Reliab. Eng. Syst. Saf.
In the field of earthquake engineering, Fragility Curves (FCs) have become indispensable for regional risk assessments due to their efficacy in estimating the failure probabilities of diverse structures, including buildings and bridges, based on certain intensity measures.
Monti, Giorgio, Rahmat Rabi, Raihan, Demartino, Cristoforo   +2 more
openaire   +2 more sources

The Fragile Definition of State Fragility [PDF]

We investigates the link between fragility and economic development in sub-Saharan Africa over a yearly panel including 28 countries for the 1999-2004 period.
Graziella Bertocchi, Andrea Guerzoni
core  

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source