Results 91 to 100 of about 2,213,618 (351)
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
Evaluation of analytical methodologies to derive vulnerability functions [PDF]
, 2012 The recognition of fragility functions as a fundamental tool in seismic risk assessment has led to the development of more and more complex and elaborate procedures for their computation.
Crowley, H. +4 more
core +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Fragility of Highway Embankments Exposed to Permanent Deformations Due to Underlying Fault Rupture
GeosciencesSeismic risk expresses the expected degree of damage and loss following a catastrophic event. An efficient tool for assessing the seismic risk of embankments is fragility curves.
Eleni Petala, Nikolaos Klimis
doaj +1 more source
The glass transition of two-dimensional binary soft disk mixtures with large size ratios
, 2010 We simulate binary soft disk systems in two dimensions, and investigate how the dynamics slow as the area fraction is increased toward the glass transition. The "fragility" quantifies how sensitively the relaxation time scale depends on the area fraction,
Kurita, Rei, Weeks, Eric R.
core +1 more source
Flood fragility analysis for bridges with multiple failure modes [PDF]
, 2017 Bridges are one of the most important infrastructure systems that provide public and economic bases for humankind. It is also widely known that bridges are exposed to a variety of flood-related risk factors such as bridge scour, structural deterioration,
American Association of State Highway and Transportation Officials (AASHTO) +19 more
core +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Fragility Curves Derivation for a Pile-Supported Wharf
International Journal of Maritime Technology, 2013 This study aims to develop seismic fragility curves for a typical pile-supported wharf. Fragility curve is one of the popular tools in seismic performance evaluation of a structure.
Hamid Heidary Torkamani +2 more
doaj
An efficient methodology to estimate probabilistic seismic damage curves [PDF]
, 2019 The incremental dynamic analysis (IDA) is a powerful methodology that can be easily extended for calculating probabilistic seismic damage curves. These curves are metadata to assess the seismic risk of structures.
Barbat Barbat, Horia Alejandro +3 more
core +2 more sources
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source