Results 71 to 80 of about 16,975 (302)

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Development of fragility curves for localised pull-through failures of thin steel roof battens

, 2016
Recent extreme wind events such as tropical cyclones and severe storms have shown that thin steel roof battens fail prematurely at their screw connections to the rafters or trusses. The screw heads connecting the bottom flanges of thin steel roof battens
Mahendran, Mahen, Sivapathasundaram, Mayooran   +1 more
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Mechanical-Analytical Soil-Dependent Fragility Curves of Existing RC Frames with Column-Driven Failures

Buildings, 2021
In seismic risk estimation, among the different types of fragility curves used (judgement-based, mechanical, empirical/observational, hybrid), the mechanical ones have the twofold advantage of allowing a better control over the basic parameters and of ...
Raihan Rahmat Rabi, Vincenzo Bianco, Giorgio Monti   +2 more
doaj   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Fragility curves for hardfill dams under seismic loading / Curvas de fragilidad para presas de hardfill bajo carga sísmica

Tecnología y ciencias del agua, 2020
Hardfill dams are comprised of cemented granular materials gathered directly from the river bed or its surroundings, or which are by-product of the dam excavation.
Grissel Hurtado-López, Juan Manuel Mayoral-Villa   +1 more
doaj   +1 more source

Fragility and Vulnerability Analysis of an RC Building with the Application of Nonlinear Analysis

Buildings, 2021
In this paper, the seismic response of a five-story reinforced concrete (RC) frame system building is analysed through fragility analysis. The structure is designed in accordance with structural Eurocodes EN1990, EN1991, EN1992 and EN1998, as a high ...
Radomir Folić, Miloš Čokić
doaj   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Seismic risk analysis of multistory reinforced concrete structures in Saudi Arabia

Case Studies in Construction Materials, 2018
In this research, analytical fragility curves for typical mid-rise plane reinforced concrete moment-resisting frames in Kingdom of Saudi Arabia, KSA, which is considered low-seismicity area, are presented.
Yasser E. Ibrahim
doaj   +1 more source