Results 91 to 100 of about 16,975 (302)

Fragility of Highway Embankments Exposed to Permanent Deformations Due to Underlying Fault Rupture

Geosciences
Seismic risk expresses the expected degree of damage and loss following a catastrophic event. An efficient tool for assessing the seismic risk of embankments is fragility curves.
Eleni Petala, Nikolaos Klimis
doaj   +1 more source

Seismic fragility curves for soft-storey buildings

, 2006
Buildings with a soft-storey are notoriously vulnerable to collapse under strong earthquake shaking. However, a building subject to a small or moderate magnitude earthquake has a fair chance of survival depending on the drift demand on the softstorey ...
John Wilson (18926458), Kittipoom Rodsin (19117423), Helen Goldsworthy (18999566), Nelson T. K. Lam (19008725)   +3 more
core   +1 more source

Empirical fragility curves for Italian URM buildings

, 2020
This paper illustrates the derivation of an empirical fragility model for residential unreinforced masonry (URM) buildings, calibrated on Italian post-earthquake damage data and compatible with the key features of the Italian national seismic risk ...
Annalisa Rosti, Maria Rota, Andrea Penna
core   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Fragility Curves Derivation for a Pile-Supported Wharf

International Journal of Maritime Technology, 2013
This study aims to develop seismic fragility curves for a typical pile-supported wharf. Fragility curve is one of the popular tools in seismic performance evaluation of a structure.
Hamid Heidary Torkamani, Khosrow Bargi, Rouhollah Amirabadi   +2 more
doaj  

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

Study on the Uncertainty of Input Variables in Seismic Fragility Curves Based on the Number of Ground Motions

Applied Sciences
Seismic fragility curves, derived from ground motion data, are essential tools for predicting and assessing potential damage to structures during earthquakes.
Sangki Park, Dongwoo Seo, Kyusan Jung, Jaehwan Kim   +3 more
doaj   +1 more source

Fragility curves for tsunami loading

, 2015
Vulnerability to structural damage can be characterized by a fragility curve, which is expressed as the conditional probability of reaching or exceeding a particular damage state, expressed by a lognormal cumulative probability distribution, given a ...
Dias, WPS, Nanayakkara, KIU
core  

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source